Sepsis Flashcards
Does SIRS always indicate infection?
No
MAP must be below what to define septic shock?
65
Lactate must be what after fluid resus to define septic shock?
Greater than 2
How is lactate cleared from the body?
Liver and kidneys
How soon should abx be started in sepsis?
Within 1 hour of presentation
How fast should 30cc/kg of NS be given in sepsis?
Within first 3 hours
What is first line pressor in sepsis?
Norepi
What does DTTP stand for?
Differential time to positivity
What is a normal anion gap?
8-12
What are the two major reasons you can have an anion gap?
Increased acid load or decreased buffer load
What are two most likely causes of non anion gap acidosis?
Renal tubular acidosis, excess GI losses (ie diarrhea)
What are two most likely causes of anion gap acidosis?
Lactic acidosis, DKA
What is IV extravasation?
When IV meds leak beyond tissues
What two meds cause extravasation?
Calcium and vasopressors
6-D-glucan assay tests for what?
Fungal infections
Should steroids be used in sepsis?
No
What is combination therapy?
Giving more than one abx for the same organism or class of organism
What tidal volume should a sepsis pt be on?
6-8mL/kg
Plateau pressure should be below what in septic pt?
Below 30
Should septic pts have permissive hypercapnia?
Yes
Fibrinogen is low or high in sepsis?
Low
Fibrin degradation product is low or high in sepsis?
High
Sepsis causes what type of AKI?
Acute tubular necrosis
When might you give a septic pt steroids?
Refractory hypotension after pressors
What does AEIOU stand for?
Acidemia, electrolyte abnormality, intoxication, volume overload, uremia
