Sepsis

Question 1

Define sepsis

Answer 1

Life threatening organ dysfunction caused by a dysregulated host response to infection

Question 2

What consitiutes organ dysfuncition?

Answer 2

Cardio:
SBP <90, MAP <65

Renal:
Oliguria <0.5ml/kg for 2hrs
Creatinine >177 mcmol/L

Hypoperfusion:
Serum lactate >2 ( if >4 mortality at 40%)

Hypoxia:
SpO” <90% or needs O2

Marrow/clotting
Platelets <100
INR >1.5
aPPT ?

Question 3

What is septic shock?

Answer 3

Sepsis + hypotension unresponsive to fluid

More serious than sepsis alone - >40% mortality

Question 4

What is the sepsis 6?

Answer 4

BUFALO: 
Blood cultures - before Abx  
Urine - catheter 
Fluids - IV 
Abx - broad spec 
Lactate - serum 
Oxygen - high flow 

All done within the 1st hour from when sepsis is suspected