Sepsis

Question 1

What does SIRS stand for?

Answer 1

Systemic Inflammatory Response System

Question 2

What is Sepsis?

Answer 2

SIRS positive & Infection

Question 3

What is the SIRS criteria?

Answer 3

2 OR MORE OF:
Temp >38 or <34
HR >90
RR >20
WBC >12000cells/mm2 or <4000cells/mm2

Question 4

What is severe sepsis?

Answer 4

Sepsis + end organ damage

Question 5

What is a classic blood finding in severe sepsis?

Answer 5

Elevated serum lactate

Question 6

What is septic shock?

Answer 6

Severe sepsis + Hypotension (requiring vasopressors to keep above 65mmHg)

Question 7

What is the hospital mortality in septic shock?

Answer 7

40%

Question 8

In any patient with an infection, what assessment should be done? And what similar assessment if it is an emergency?

Answer 8

SOFA

qSOFA

Question 9

How should sepsis be managed?

Answer 9

Sepsis 6:

Blood cultures
Measure and monitor urine output
Blood lactate - general indicator and marker of poor prognosis

Antibiotics dependant on case history
O2 - stats need to stay above 94%
IV Fluid challenge

Question 10

What are some indicators of severe sepsis?

Answer 10

low BP that is not responding to fluids
lactate <2
increased CCK
oliguria
liver dysfunction