Sepsis Flashcards

1
Q

How is sepsis defined in the Sepsis 3 study?

A

A life threatening organ dysfxn caused by dysregulated host response to infection

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2
Q

What is the Sepsis-3 definition of septic shock?

A

Septic shock is defined as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities substantially increase mortality. sepsis with persisting hypotension requiring vasopressors to maintain MAP ≥ 65mmHg and serum lactate ≥ 2mmol/L despite adequate volume resuscitation

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3
Q

What is the qSOFA score

A
  • Resp rate >22
  • ALOC
  • SBP
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4
Q

What does the qSOFA score predict?

A

identifies patients at risk of sepsis

2+ criteria identify patients at increased risk of ICU stays of 3+ days or in hospital mortality

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5
Q

What are the elements of the SOFA score

A
PF ratio
platelets
Bilirubin
MAP
GCS
Cr
Urine output
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6
Q

List differential for sepsis and septic shock

A
Sepsis
dehydration
ARDS
anemia
ischemia
hypoxia
CHF
vasculitis
tox
pancreatitis
hypothalamic injury
DIC
anaphylaxis
hyperthyroidism
DKA
adrenal dysfunction
trauma
NMS

Septic Shock

Hypovolemic shock
acute blood loss
severe dehydration
cardiogenic shock
PE
MI
pericardical tamponade
tPTX
vasogenic shock
anaphylaxis
paralysis
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7
Q

What are potential sources to consider in sepsis

A
o UTI
		§ Complicated pyelonephritis / perinephric abscess
	o CNS:
		§ CSF
		§ Epidural abscess – spine or intracranial
	o Open wounds
	o RTI:
		§ Respiratory secretions
		§ Empyema
	o Cardiac:
		§ Infective Endocarditis
	o GI
		§ Stool
		§ Intra-abdominal infections
			· C. difficile
			· Ischemic gut
			· Perforated viscus
			· Abscess
			· Ascending cholangitis
			· Gangrenous cholecystitis
			· Necrotizing pancreatitis
	o Indwelling lines and catheters
	o Soft tissue and Joints:
		§ Necrotizing soft tissue infections
		§ Septic arthritis
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