sensory systems Flashcards

1
Q

contrast general senses and special senses

A

GENERAL SENSORS:

  1. nociceptors (pain receptors)
  2. thermoreceptors (sensitive to warm or cold; or sensitive to change in temperature)
  3. mechanoreceptors (tactile receptors and proprioceptors)
    - sensory receptors distributed throughout the body, mostly in skin
    - information is MAINLY transmitted via spinal nerves to spinal cord

SPECIAL SENSES:

  1. olfaction (smell; chemoreceptors)
  2. gustation (taste; chemoreceptors)
  3. vision (sight; photoreceptors)
  4. hearing + equilibrium (balance); mechanoreceptors)
    - sensory receptors found in the head
    - information is ONLY transmitted via cranial nerves to brain
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2
Q

structure of spinal nerves

A
DORSAL = SENSORY
VENTRAL = MOTOR

spinal nerve —> dorsal/ventral roots —> dorsal root ganglia —> dorsal/ventral rootlets

  • dorsal rootlets enter the spinal cord at the dorsolateral sulcus
  • ventral rootlets exit the spinal cord at the ventrolateral sulcus
  • dorsal root ganglia contain cell bodies of sensory neurons
  • dorsal & ventral roots merge to form the spinal nerve
  • dorsal medial sulcus down centre of spinal cord
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3
Q

relationship between receptor type, fibre diameter and conduction velocity

A

EXPLORATIVE SENSES:

  • touch + proprioception
  • mechanoreceptors
  • have larger axon diameter = faster conduction
  • part of dorsal column medial system
  • larger cells

PROTECTIVE SENSES:

  • pain, temperature, itch
  • have smaller axon diameter = slower conduction
  • part of anterolateral system
  • smaller cells
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4
Q

anatomy of the spinal cord (individual vertebrae)

A

dorsal side:

  • dorsal median sulcus
  • posterior intermediate sulcus (thoracic and cervical)
  • posterolateral sulcus
  • gracile fascicles (medial)
  • cuneate fascicles: larger than gracile –> more nerve fibres for innervation of fine motor control in upper limbs

anterior side:

  • anterior median fissure
  • anterolateral sulcus

white matter surrounds grey matter

white matter divided into 3 funiculi:

  • –> dorsal funiculus (column)
  • ** dorsolateral sulcus ***
  • –> lateral funiculus
  • ** anterolateral sulcus ***
  • –> anterior funiculus

grey matter divided into 3 horns:

  • –> dorsal grey horn
  • –> lateral grey horn
  • –> anterior grey horn

ratio of white/grey matter changes throughout spinal cord:

  • —> largest amount of white ma_er is found in the cervical cord as all axons from/to the brain pass through it
  • —> grey matter of cervical/lumbar/sacral are expanded to include more sensory input from limbs and more cell bodies for motor control of limbs
  • anterior horn carries motor commands from brain to body (α-Motoneurons)
  • dorsal horn carries sensory (e.g. temperature, pain) feedback from body to brain
  • lateral horn carries autonomous nervous system for visceral organs (present only at T1-L2, S1-S3)
  • white mater (3 funiculi) contain ascending and descending axons (nerve fibres)
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5
Q

gross anatomy of spinal cord

A
  • spinal cord is 45cm long
  • contains 31 pairs of spinal nerves
  • cervical enlargement:
  • —> spinal nerves that supply shoulder and upper limbs
  • lumbar enlargement:
  • —> spinal nerves that supply pelvis and lower limbs
  • at the caudal end, tapers into conus medullairs (a cone shaped structure)
  • thread of fibrous tissue attaches the conus medullaris to the 1st coccygeal vertebra = filum terminale
  • cauda equina = bundle of spinal nerve roots below conus medullaris
  • —> the spinal cord stops growing in childhood, while the vertebral column continues growing
  • —> spinal cord ends at L1/2 in adults
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6
Q

where is sensory information processed before reaching the cortex?

A

sensory information passes through the thalamus before reaching the cortex

the thalamus consist of discrete nuclei and each sensory modality has a different relay nucleus

each of these nuclei projects to a particular cortical area, called the primary sensory cortical area for that sensation

olfaction bypasses thalamus and goes straight to cortex

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7
Q

after the thalamus, what structure does sensory information pass through before reaching the cortex?

A

sensory information reaches the cortex via the posterior limb of the internal capsule

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8
Q

dorsal column-medial lemniscus’ pathway

A

how explorative senses (proprioception + touch) reach the cortex

—> receptive organ
—> dorsal root ganglion (1st order)
—> dorsal root
—> dorsal column:
~~~~~~lower body fibres enter the gracile fascicle (T6 and down —> )
~~~~~~upper body fibres enter the cuneate fascicle (above T6)
—> dorsal column nuclei in medulla (2nd order)
—> 2nd order neurones travel through medial lemniscus pathway and decussate via internal arcuate fibres to contralateral VPL thalamus (3rd order)
—> primary somatosensory cortex via posterior limb of internal capsule

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9
Q

anatomy of the dorsal column

A

composed of fascicles:

  • —> gracile fascicles either side of dorsal median sulcus
  • —> cuneate fascicles lateral side of dorsal intermediate sulcus

contains gracile tubercle (nucleus) and cuneate tubercle (nucleus)

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10
Q

anterolateral pathway

A

how protective senses (temp + pain + itch) reach the cortex

—> receptive organ
—> dorsal root ganglion (1st order)
—> dorsal rootlets
—> ducussate at ventral commisure
—> ascend via spinothalamic tract
—> travel to contralateral VP thalamus (3rd order)
—> primary somatosensory cortex via posterior limb of internal capsule

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11
Q

pathway for ‘unconscious’ proprioception

A

—> dorsal root ganglion (1st order)
—> Clarke’s nucleus (2nd order = collectively called spinocerebellar tracts)
—> all spinocerebellar tracts end in ipsilateral cerebellar part

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12
Q

which cranial nerve is the principle pathway for sensation from the head and face?

where does it originate?

what is the thalamic relay for this nerve?

which branches supply why areas?

A

trigeminal nerve (CN V)

originates at the pons

thalamic relay for sensory trigeminal nerve is ventral posterior medial nucleus (VPM)

the ophthalmic branch (V1) carries info from orbit, cornea, bridge of nose, scalp and forehead

the maxillary branch (V2) carries info from corners of eyes and mouth

the mandibular branch (V3) carries info from lower part of face. also carries motor fibres for muscles of mastification

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13
Q

describe the different nuclei contained within the sensory trigeminal nerve (CN V)

A

MAIN TRIGEMINAL NUCLEUS

  • located at pons
  • relays touch and mechanical sensation
  • joins anterolateral system

SPINAL TRIGEMINAL NUCLEUS

  • located in lower pons and medulla
  • 2º neurons
  • relays pain, temperature and itch

*** main and spinal trigeminal nuclei project with fibres of medial lemniscuss + anterolateral pathway (respectively) to VPM

MESENCEPHALIC TRIGEMINAL NUCLEUS

  • primary sensory neurons with cell body located in brain
  • receives input from jaw proprioceptors
  • projects to main + spinal trigeminal nuclei
  • fibres decussate to join medial lemniscuss
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14
Q

how is visual sensory information transmitted from eye to brain?

A
  1. light hits fovea
  2. light travels to back of eye, detected by photoreceptors in neural retina
  3. converted to electrical signals
  4. travels to interneurons
  5. retinal ganglia relay to brain via the optic nerve (CN II)
  6. a) terminates in dorsal layers of superior colliculus = unconscious reflexive eye movement
  7. b) lateral geniculate nucleus in thalamus —> primary visual cortex = conscious
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15
Q

describe the different types of cells in the eye

A

cone cells:

  • function in bright lgiht
  • colour vision
  • high visual acuity as they only connect to few bipolar cells

rod cells:

  • function in low light
  • night vision
  • low acuity as they connect to many bipolar cells

horizontal cells:
- sharpen contrast

amacrine cells:
- regulate sensitivity

retinal ganglion cells:
- carry visual info to brain via optic nerve

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16
Q

retinal ganglion cell axons from which hemiretinae decussate at the optic chiasm?

what does this achieve?

A

RCG axons from the nasal hemiretina decussate at the optic chiasm

temporal hemiretina axons stay ipsilateral

allows left and right visual fields to be separated and processed in the contralateral hemisphere

17
Q

describe the organisation of the primary visual cortex

A

primary visual cortex = V1

superior half of visual field = inferior bank of calcarine sulcus

inferior half of visual field = superior bank of calcarine sulcus

macula (centre of visual field) = occipital pole

peripheral visual field = rostral V1

18
Q

describe the organisation of the lateral geniculate nucleus (LGN)

A

consists of 6 layers which each receive exclusive input from ipsilateral or contralateral eye:
(ventral) C, I, I, C, I, C (dorsal)

parvocellular layers:

  • dorsal 4 layers
  • receive projections from P-type RGCs
  • specialised for shape and colour

magnocellular layers:

  • ventral 2 layers
  • receive projections from M-type RGCs
  • specialised for movement detection

in between the 6 layers, there are INTRALAMINAR NEURONS which relay colour info to V1

19
Q

what are ocular dominance columns

are there any other specialised columns?

A

nuclei are segregated into columns

keeps left and right visual info separated at thalamus and V1

info only integrated at higher cortical areas

removing one eye shows some ocular dominance columns becoming inactive

ORENTATION COLUMNS:
- segregated by intracortical connections as opposed to the eye

COLOUR BLOBS:
- located in cortical layers 2 and 3 of ocular dominance columns

20
Q

where does visual info project after reaching V1?

A

projection depends on what type of RCG the signal originated from

M-type RGCs:

  • –> magnocellular neusons
  • –> travels upwards to posterior parietal lobe
  • —> V5 = “where:, movement, depth

P-type RGCs:

  • –> parvocellular neurons
  • –> travels to temporal lobe
  • –> V4 = “what”, object recognition

V1 and V2 are involved in both streams

21
Q

describe the structure of the superior colliculi

A

laminated structures = layered

visual info processed in dorsal layer

anterolateral and auditory info processed in ventral layer

tectospinal pathway originates in ventral layer

22
Q

auditory pathway

A
  1. soundwaves vibrate the tympanic membrane
  2. auditory ossicles vibrate to amplify the pressure
  3. pressure waves created by stapes push on oval window
  4. scala vestibula (fluid in cochlea) vibrates
  5. sounds in hearing range vibrate the basilar membrane
  6. inner hair hells and stimulate vestibular-cochlea nerve
  7. travels to cochlea nuclei:
    - –> dorsal portion processes sound from vertical axis and connects directly to inferior colliculus
    - –> anteroventral portion receives sound from horizontal plane (superior olivary complexes
    - –> posteroventral portion
  8. travels to medial geniculate nucleus via inferior brachium
  9. primary auditory complex (posterior and superior portion of superior tempotal gyrus)
    - –> high tones are medial
    - –> low tones are lateral
  10. travels to secondary auditory cortex for interpretation of sound
  11. (“where” pathway) projections to posterior parietal cortex for interpretation of where sound came from
  12. connections to prefrontal and motor regions for planning movement in response to sound

“what” pathway is less well defined

23
Q

what is the role of the superior olivary complex?

A

spatial localisation of sounds from horizontal plane

low frequency: compares how long it takes to travel from left to right ear

high frequency: compares intensity between left and right ears

24
Q

olfactory pathway

A

** sensory neurons = bipolar neurons **

  1. olfactory nerve fibres dangle through olfactory epithelium
  2. project through cribiform plate to synapse on olfactory bulb (olfactory bulbs connected via anterior commissure [medial stria])
  3. 2º neurons in olfactory bulb connect via olfactory tract to uncus (laterl stria)
  4. uncus connects to olfactory cortex

NOTE: no thalamic relay