Sensory Processing Flashcards

1
Q

The swaying of stereocilia in response to sound waves results in an influx of _______ at the base of the hair cell.

  • K+
  • Cl-
  • Ca2+
  • Na+
A

Ca2+

(The correct answer is ‘Ca2+’ - after depolarization by the influx of Na+ and K+ when stereocilia are bent, voltage-gated Ca2+ channels will open and cause vesicles to release glutamate into the synapse.)

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2
Q

Which of the following would disrupt sound perception?

  • An antagonist for glutamate at the synapse between IHCs and afferent nerve fibers
  • At the synapse between IHCs and afferent nerve fibers
  • An agonist for glutamate at the synapse between IHCs and afferent nerve fibers
  • An agonist for GABA at the synapse between IHCs and afferent nerve fibers
A

An antagonist for glutamate at the synapse between IHCs and afferent nerve fibers.

(The correct answer is ‘An antagonist for glutamate at the synapse between IHCs and afferent nerve fibers’ - glutamate is the NT released from the IHCs. Based on knowledge from our chemistry of behavior unit, we know that an antagonist will bind but not activate a neuron.)

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3
Q

For most senses, the sensory pathway ______________.

  • Passes through the thalamus
  • Passes through the spinal cord
  • Goes directly to its designated area of cortex
  • Passes through the temporal cortex
A

Passes through the thalamus

(The correct answer is ‘passes through the thalamus’ - the thalamus is the sensory relay station in the brain and processes all incoming sensory information except if its coming from the olfactory system.)

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4
Q

Complete the analogy, thinking about the concept of ‘coding’: Place theory: _______________: Temporal theory: ____________.

  • number of neurons firing; rhythm of neuronal firing
  • IHC identity; number of neurons firing
  • action potential firing rate (frequency); IHC location
  • IHC identity; action potential firing rate (frequency)
A

IHC identity; action potential firing rate (frequency)

(The correct answer is ‘IHC identity; action potential firing rate (frequency)’ - the location (and thus identity) of an IHC determines what pitch it encodes, based on the place theory. But the rate (frequency) at which it fires is how pitch is coded based on the temporal theory.)

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5
Q

The brain can differentiate between each sensory modality through the principle of labeled lines because

  • The action potentials for each one are sent along separate nerve tracts.
  • Each sense uses different neurotransmitters.
  • Each sensory input, passing through the same lines, triggers action potentials in a different pattern.
  • The action potentials, sent along the same nerve tracts, get sorted by the thalamus.
A

The action potentials for each one are sent along separate nerve tracts.

(The correct answer is ‘the action potentials for each one are sent along separate nerve tracts.’ - this is why if you press lightly on your eye you will see a blob in your visual field – your brain expects information coming from cells in your eye to be visual.)

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6
Q

Receptors in our skin transduce pressure information into neural signals when deformation of the skin…

  • causes depolarization subcutaneously such that voltage-gated ion channels open and potassium enters the cell
  • causes ion channels to change shape and open, letting sodium enter the cell
  • causes ion channels to change shape and open, letting sodium exit the cell
  • causes depolarization subcutaneously such that voltage-gated ion channels open and potassium exits the cell
A

Causes ion channels to change shape and open, letting sodium enter the cell.

(The correct answer is ‘causes ion channels to change shape and open, letting sodium enter the cell’ - these receptors are mechanoreceptors, and are a special class of receptor, just like ligand-gated or voltage-gated.)

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7
Q

Sensory transduction is the process by which

  • Energy is converted into a change in membrane potential – action potentials are used by neurons to communicate.
  • Electrical responses are converted into movement.
  • Adaptive responses are produced
  • One type of sensory stimulus is converted into a different type of sensory stimulus.
A

Energy is converted into a change in membrane potential – action potentials are used by neurons to communicate.

(The correct answer is ‘energy is converted into a change in membrane potential – action potentials are used by neurons to communicate.’ - this has to happen in sensory receptor cells or environmental stimuli cannot be processed by the brain.)

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8
Q

Your younger cousin learned in class that birds can sense the earth’s magnetic field. She thinks this is a cool skill, and asks if you know how she can learn to do this too. You explain that unfortunately, this isn’t something she can learn. If you wanted to explain why in technical terms, which of the following should be incorporated into your explanation?

  • Labeled lines
  • Absolute threshold
  • Adequate stimulus
  • Sensory adaptation
A

Adequate stimulus

(The correct answer is ‘adequate stimulus’ - for stimulus energies to be processed by our brains, they need to be an adequate stimulus for a particular type of sensory receptor. We don’t have sensory receptors that can process the magnetic field.)

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9
Q

Which skin receptors are especially sensitive to stretching of the skin?

  • Messiner corpuscles
  • Merkel discs
  • Pacinian corpuscles
  • Ruffini endings
A

Ruffini endings

The correct answer is ‘Ruffini endings’ - these are deep in the skin and respond to stretch.

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10
Q

You would expect a sensory receptor in the lips to have a ________________ than a sensory receptor in the elbow. If the sensory receptor stopped responding to a repetitive stimulus, you would also say that it was _______________.

  • smaller receptive field; phasic
  • smaller receptive field; tonic
  • larger receptive field; tonic
  • larger receptive field; phasic
A

smaller receptive field; phasic

(The correct answer is ‘smaller receptive field; phasic’ - you need more precise perception of touch in your lips than in your elbow, thus you will have smaller receptive fields. If a neuron stops responding during static stimulation, we call it phasic.)

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11
Q

True or False:

Environmental input affects how our brains develop and function and even what parts of our genes are transcribed

A

True

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12
Q

What is sensation?

A

The process of receiving stimulus energies from the external environment and transforming them into neural energy

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13
Q

How we organize and interpret this information so it has meaning is the process of _______.

A

perception

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14
Q

How do we sense stimuli?

A
  • Sensory receptor organs

- Sensory receptor cells

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15
Q

To be detected, a receptor cell must receive…

A

an adequate stimulus

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16
Q

True or False:

Receptors in our skin are distributed uniformly

A

False

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17
Q

To be detected, a receptor cell must receive stimulus energy passing an…

A

absolute threshold

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18
Q

What is sensory transduction?

A

Receptor cells convert energy into electrical signals

Action potentials!

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19
Q

___________ changes based on input

A

Receptor potential

Generally, similar to an EPSP
(All-or-none signal)

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20
Q

How can we process such a wide variety of stimuli with just action potentials to relay messages (initially)?

A

By coding

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21
Q

What is coding?

A

Rules by which action potentials in a sensory system reflect a physical stimulus

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22
Q

What affects stimulus intensity?

A
  • Frequency of AP
  • Rhythm of AP
  • Number of neurons firing AP
  • Identity of neurons firing

(Range fractionation)

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23
Q

True or False:

Each sensory system we have has a different processing pathway

A

True

These are so distinctive, you can trick your brain.

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24
Q

What are the levels of sensory processing?

A

Receptors –> spinal cord/brainstem –> thalamus –> primary sensory cortices

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25
Q

What system does not experience the typical levels of sensory processing?

A

The olfactory system

The olfactory system does not synapse through the thalamus.

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26
Q

What is adaptation?

A

the phenomenon by which receptors become less and less responsive as stimulus is maintained

(Phasic vs. tonic receptors)

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27
Q

__________ can reduce the level of input we get through a sensory receptor.

A

Accessory structures

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28
Q

Why is sensory processing considered top-down processing?

A

Through processing and integration, we perceive our surroundings.

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29
Q

What are phasic receptors?

A

Receptors that show adaptation

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30
Q

What are tonic receptors?

A

Receptors that do not show adaptation

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31
Q

In the somatic sensory system, what is the sensory organ and sensory receptors?

A

Sensory organ: skin

Sensory receptor: different types

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32
Q

What types of information do you have to pick up through your skin?

A

Mediates a range of sensations:

  • Touch
  • Pressure
  • Vibration
  • Heat/Cold
  • Pain
  • Limb position
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33
Q

Information is transduced by ________ in skin and muscles and innervated by __________.

A

mechanoreceptors; dorsal root ganglion neurons

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34
Q

What does it take for an AP to fire?

A
  • Depolarization of neurons
  • Ligand-gated ion channels
  • Voltage-gated ion channels
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35
Q

What are the steps for mechanoreceptors?

A

Deformation of channel –> channel opens –> Na+ into cell

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36
Q

What are the different types of terminal endings?

A
  • Meissner corpuscle
  • Merkel cell
  • Ruffini ending
  • Pacinian corpuscle
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37
Q

What distinguishes between the receptor types?

A
  • Receptive fields
  • Adaptation properties
  • Sensory thresholds
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38
Q

What are receptive fields?

A

The region of skin in which a stimulus will modify the firing of an action potential

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39
Q

Receptive fields are affected by…

A
  • Branching characteristics of afferent within skin

- Density of afferent fibers supplying the area

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40
Q

What are adaptation properties?

A

Temporal dynamics of response to sensory stimuli

41
Q

What are slow adapting receptors?

A
  • Initial spiking proportional to speed skin is indented and total amount of pressure
  • Steady pressure - firing rate proportional to skin indentation
42
Q

What are rapidly adapting neurons?

A
  • Cease firing in response to constant amplitude stimulation

- Active when velocity of stimulation changes

43
Q

What activates slow adaptation?

A

Information about spatial attributes of stimulus

Size, shape, mass

44
Q

What activates fast adaptation?

A

Information about changes in ongoing stimulation

stimulus movement

45
Q

What are sensory thresholds?

A

Minimum intensity of stimulation required to generate an AP

different for fast vs. slow adapting neurons

46
Q

What are the characteristics of Pacinian afferents?

A
  • 10-15% of afferents
  • Deep in hypodermis
  • Look like small onions
  • Detect vibrations transmitted through objects being grasped
  • Frictional displacement of skin when hand moves across object
47
Q

What are the receptive fields, adaptation properties, and sensory thresholds of Pacinian afferents?

A

Receptive fields: large and ambiguous

Adaptation properties: fast-adapting

Sensory threshold: low response threshold

48
Q

What are the characteristics of Meissner corpuscle afferents?

A
  • Dense innervation of skin
  • Tips of the dermal papillae adjacent to primary ridges and closest to skin surface
  • Sensitive to abrupt changes in shapes of objects (at edges or corners)
  • Localized bumps on smooth surface
49
Q

What are the receptive fields, adaptation properties, and sensory thresholds of Meissner corpuscle afferents?

A

Receptive fields: relatively small

Adaptation properties: fast-adapting

Sensory threshold: low response threshold

50
Q

What are the receptive fields, adaptation properties, and sensory thresholds of Merkel cell afferents?

A

Receptive field: highest spatial resolution (0.5 mm)

Adaptation properties: slow-adapting

Sensory threshold: high response threshold

51
Q

What are the characteristics of Merkel cell afferents?

A
  • Especially dense in fingertips
  • Only afferent to sample information from receptor cells located in epidermis
  • Good for curvature/form of objects (concave, convex)
  • Fine details
52
Q

What are the receptive fields, adaptation properties, and sensory thresholds of Ruffini afferents?

A

Receptive fields: large, vague

Adaptation properties: slow-adapting

Sensory threshold: high response threshold

53
Q

What are the characteristics of Ruffini afferents?

A
  • Least understood
  • Elongated, spindle-shaped
  • Deep in dermis; ligaments and tendons
  • Respond to internally generated stimuli
  • Stretch of skin
54
Q

How do we process sound? (Answer must include the sensory organ, sensory receptors, and adequate stimuli)

A
  • Sensory organ: ear (cochlea)
  • Sensory receptors: inner hair cells (IHCs)
  • Adequate stimuli: sound (pressure waves)
55
Q

Sound waves are…

A

vibrations in the air

56
Q

What do we detect about sound?

Think about sound - how do sounds differ from each other?

A
  • Pitch (high vs. low)
  • Loudness
  • Timbre (quality of sound)
57
Q

What is pitch?

A

frequency: wave length

how many cycles pass a given point in 1 second

58
Q

What is loudness?

A

Amplitude: ‘height’ (intensity) of a sound wave

Contains a crest and a trough

59
Q

What is timbre?

A

Complexity: sounds with numerous frequencies of sound blended together

60
Q

How do we actually process this sound information​?

A

We use our ears.

Outer, middle, and inner ear

61
Q

The outer ear is comprised of ______ + _______.

A
  • Pinna

- Ear canal

62
Q

What is between the outer ear –> middle ear?

A

The tympanic membrane (eardrum)

End of ear canal.

63
Q

What protects your ears from loud sounds?

A

Muscles

Contract ~ 200 msec after loud sound

64
Q

In the middle ear, the tympanic membrane attaches to the _______.

A

malleus

65
Q

What comprises ossicles?

A
  • Malleus
  • Incus
  • Stapes

(They are the smallest bones in the body.)

66
Q

In the middle ear –> inner ear, the stapes pushes on the _________ connecting to the inner ear.

A

oval window

67
Q

In the inner ear, sound (coded mechanically in the middle ear) is converted into neural activity in the ________.

A

cochlea

68
Q

The scala vestibuli is attached to the _______.

A

oval window

69
Q

The scala media contains the ___________ which sits under the ______________.

A

basilar membrane; organ of corti

70
Q

The scala tympani is attached to the _________.

A

round window

71
Q

What happens as a result of pressure into the inner ear (via the oval window) from the stapes?

A

Fluid is pushed towards the only elastic part of the chamber.

72
Q

What happens as a result of increased pressure in the scala tympani?

A

A bulge in the round window

73
Q

The motion of the scala vestibuli and scala tympani causes vibrations in the __________.

A

basilar membrane

74
Q

What are the characteristics of the basilar membrane?

A
  • Thickness and width vary

- These properties affect mechanical properties of the membrane

75
Q

Different frequencies cause ___________ at different points on the basilar membrane.

A

maximum displacement

76
Q

_________ are the sensory receptors for audition.

A

Inner hair cells

77
Q

Vibrations cause changes in IHCs that lead to __________.

A

sensory transduction

78
Q

‘Wave’ travels along basilar membrane and peaks under particular _______.

A

IHCs

79
Q

True or False:

IHCs are most sensitive to a particular frequency but will respond to similar frequencies.

A

True

finely tuned!

80
Q

What are the mechanics of an IHC response?

A
  1. Basilar membrane driven upwards –> shearing motion between tectorial membrane and organ of Corti –> bending of sterocilia –> EXCITATION
  2. IHCs stereocilia extend into the bottom of the tectorial membrane
  3. Basilar membrane moves downward –> opposite –> bending of sterocilia in opposite direction –> INHIBITION
81
Q

What are​ the steps that lead up to sensory transduction?

A
  1. Bending of stereocilia –> tip links pop open
  2. Ion channels allow K+ and Ca2+ to depolarize the IHC
  3. Depolarization opens voltage-gated Ca2+ channels at base of iHC
  4. Vesicles release NT (glutamte)
  5. Glutamate binds to the afferent nerve and triggers an AP

(This happens very quickly - necessary for this sensory system.)

82
Q

Information is transmitted from __________ to _______.

A

cochlear hair cells; neurons (cell bodies in cochlear ganglion)

83
Q

_________ ganglion cells innervate HCs in either ear.

A

~30,000

(90-95% terminate on IHCs
5-10% terminate on OHCs)

84
Q

_____ IHC outputs to several nerve fibers.

A

One

Average ~10

85
Q

Nerve fibers only innervate 1 ____.

A

IHC

86
Q

IHCs carry information to the brain along the ___________.

A

cranial nerve VIII (vestibulocochlear nerve)

87
Q

What is the minimal discriminable frequency difference?

A

~2 Hz

We can discriminate between pitches that differ by ~ 2 Hz

88
Q

Encoding frequency is subjectively experienced as _____.

A

pitch

89
Q

What is place coding theory?

A

The theory that the area of the basilar membrane that vibrates determines perceived pitch.

90
Q

What is temporal coding theory?

A

The theory that the rate of neuronal firing is directly related to the frequency.

(Not a 1:1 correspondence for high frequencies)

91
Q

Encoding amplitude is subjectively experiences as _______.

A

loudness

92
Q

Tuning curves –> more intense the stimulus, the more…

A

IHCs will respond

93
Q

Nerve fibers divide into ________ when they enter the brainstem.

A

two branches

94
Q

What is tonotopic organization?

A

All levels of the auditory pathway are spatially arranged according to auditory frequencies to which they respond

95
Q

Cortical processing of sound occurs in the…

A

primary auditory cortex

96
Q

What 2 processes are at work for the perception of sound?

A

Top-down and bottom-up

Very complex

97
Q

What is the mysterious melody?

A

The proximity effect

Gestalt

98
Q

What is the mysterious melody?

A

The proximity effect

Gestalt