Sensory physiology 1 Flashcards

1
Q

In general, how are electrical signals interpreted by your brain?

A

A stimulus (energy) is detected by a receptor. This energy is then transduced into action potentials, which are sent to an afferent sensory neuron. The action potentials are then sent from the afferent sensory neuron to the brain.

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2
Q

Define sensation

A

The process by which external energy is received at sensory organs, and transduced into electrical (neural) signals
- Mechanical process

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3
Q

Define perception

A

Our interpretation of neural signals
- e.g. hey that sound’s nice :3

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4
Q

Despite the vast diversity of sensations we experience, sensory systems use 4 types of information to help us differentiate between sensations. What are these 4 types of information?

A
  1. Modality
  2. Location
  3. Intensity
  4. Timing
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5
Q

Define modality as a type of information used to differentiate between sensations

A

Type of energy
- e.g. visible light vs. sound waves

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6
Q

Define location as a type of information used to differentiate between sensations

A

Set of sensory receptors that are active (e.g. where on the body certain things come into contact)
- e.g. dermatomes: area of skin where all the energy arriving at this site gets sent to the same area of the spinal cord

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7
Q

What is the labeled-lines principle with respect to location as a type of information used to differentiate between sensations

A

When you have a particular receptor type that gets activated, there are going to be isolated pathways of neurons going from that receptor different parts of the brain
- energy is isolated/contained/separate from other forms of energy

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8
Q

Define intensity as a type of information used to differentiate between sensations

A

Total amount of stimulus energy delivered to the receptor

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9
Q

Define timing as a type of information used to differentiate between sensations

A

When the stimulus starts and stops

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10
Q

True or false: humans are generally very good at perceiving the same thing, but sometimes, we can be fooled.

A

True
- e.g. optical illusions

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11
Q

True or false: perception differs among different people because sensations change

A

False
- pre-existing states can alter perception, sensation will not change

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12
Q

What are the two mechanisms of transduction?

A
  1. Ionotropic
  2. Metabotropic
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13
Q

Describe the ionotropic mechanism of transduction

A

Sensory receptor directly opens an ion channel which causes the ions to flow into the cell

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14
Q

Most receptors are (ionotropic/metabotropic)

A

Ionotropic

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15
Q

Describe metabotropic mechanism of transduction

A

Not directly linked to opening an ion channel
- invovles 2nd messenger cascade

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16
Q

What is mechanoreception mediated by?

A

Stretch activated ion channels
- With increasing stretch on the membrane a channel opens more often and for longer duration (see increased current as pressure increases and creates a vacuum that stretches the membrane)

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17
Q

How does stimulus intensity affect frequency of action potentials?

A

Greater intensity stimuli = greater frequency of action potentials

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18
Q

What is receptor adaptation?

A

Explains how a receptor behaves when a stimulus is introduced

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19
Q

What are the two types of receptors?
- 2 names for each type

A
  1. Tonic receptor aka slow-adapting receptor
  2. Phasic receptor aka fast-adapting receptor
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20
Q

Describe tonic receptors aka slow-adapting receptors

A

When we introduce a stimulus, it starts to fire action potentials and only stops when the stimulus goes away

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21
Q

Describe phasic receptors aka fast-adapting receptors

A

Good at depicting the onset and offset of a stimulus
- If a stimulus remains constant, get decrease in the number of action potentials quickly.
- action potentials also quickly fire when stimulus is removed.

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22
Q

What are the 6 mammalian mechanoreceptors?

A
  1. Pacinian corpuscles
  2. Ruffini endings
  3. Meissner’s corpuscles
  4. Merkel discs
  5. Free nerve endings
  6. Hair cell
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23
Q

Glabrous skin

A

Skin with no hair follicles
- e.g. fingertips

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24
Q

Epidermis vs dermis

A

Epidermis: thin layer, outermost layer of the skin
Dermis: Rest of the skin

25
Q

What do hair cells detect and how?

A

Detect if the hair is moved/disturbed in any way
- Stretch-activated ion channels (ionotropic) are connected by cytoskeletal strands.
- As the hair moves, cytoskeletal strands are pulled on -> opens up the channels and causes Na+ influx into hair cell -> depolarizes the cell and causes an action potential
- Ion channels open due to conformation change from the stretch

26
Q

Describe Pacinian corpuscles (3)

A
  1. Located deep in dermis
  2. Respond to vibration and deep pressure (because the receptors are located deep in the skin, light pressure won’t activate these)
  3. Rapidly adapting (phasic)
27
Q

Describe how pacinian corpuscles detect stimulus and why they’re phasic

A

If something presses deep into the skin -> makes contact with receptor ending -> waves of energy travel down from outer surface of receptor to central nerve core through fluid -> stretch-activated channels caused by disrupted nerve core, causing a graded potential and eventually an action potential if the threshold is met
- if stimulus is applied and remains constant, fluid redistributes and central nerve core moves back to initial position
- detects the onset of the stimulus, but action potentials stop if stimulus is constant
- fluid moves again when object is removed which triggers actino potentials

28
Q

Describe Ruffini endings (5)

A
  • Located deep in the dermis
  • Respond to stretch (anchored to deep dermis: as the skin stretches, the dermis pulls on the membrane of the Ruffini endings)
  • Slow adapting (as long as the skin is being stretched, it sends action potentials and the skin remains stretched)
  • Indicate limb position
  • Indicate object shape (object causes a characteristic pattern of stretch: brains can use the specific patterns to determine the shape of the object)
29
Q

Describe Meissner’s corpuscles (4)

A
  • Located superficially
  • Physiologically similar to Pacinian Corpuscle (since they’re also fluid-filled sacs)
  • Rapidly adapting
  • Fine, light, touch
30
Q

Describe Merkel discs (4)

A
  • Located superficially
  • Slow adapting
  • Semi-rigid epithelial cell (anchored to the skin, fire action potentials as long as skin is stretched)
  • Compression (e.g. when holding a pen, small indents in the skin remain compressed as long as you’re holding the pen)
31
Q

Free nerve endings are also known as…

A

Nociceptors (pain receptors)
- Detect damage or potential damage to the skin

32
Q

What are the 4 types of free nerve endings?

A
  1. Mechanical nociceptors
  2. Thermoreceptors
  3. Chemically sensitive
  4. Polymodal
33
Q

Mechanical nociceptors responds best to….

A

Physical stimuli

34
Q

Thermoreceptors respond best to…

A

Extreme hot or cold

35
Q

Chemically sensitive free nerve endings respond best to…

A

Extreme hot or cold

36
Q

Polymodal free nerve endings respond best to…

A

All stimuli (maximally activated by all stimuli)

37
Q

What is a receptive field?

A

A receptive field refers to the specific region of sensory space (like skin, for example) where a stimulus can trigger a response in a particular sensory neuron. It defines the area or range over which a single neuron is sensitive to stimuli.

38
Q

What two types of mechanoreceptors have very small receptive fields?

A

Merkel disks and Meissner’s corpuscles
- located very superficially

39
Q

What two types of mechanoreceptors have large receptive fields?

A

Ruffini endings and Pacinian corpuscles
- located deep so has a large receptive field

40
Q

Merkel disks and Meissner’s corpuscles have (greater/smaller) overlap within their receptive fields

A

Smaller

41
Q

Ruffini endings and Pacinian corpuscles have (greater/smaller) overlap within their receptive fields

A

Greater

42
Q

Which three mechanoreceptors have a higher density near the fingertips compared to the palm?

A

Merkel discs, Meissner’s corpuscles and Pacinian corpuscles
- But pacinian corpuscles respond to bigger amounts of stretch

43
Q

Which mechanoreceptor has a higher density near the palm than the fingertips?

A

Ruffini endings
- Higher density near palm compared to fingertips because fingertips don’t stretch as much as palm.

44
Q

Define two point threshold and what it is dependant on

A

The distance between 2 physical stimuli (points) where you are no longer able to detect each point separately
- The size of the threshold is dependent on receptor density and receptive fields

45
Q

What is the only mechanoreceptor that isn’t myelinated?

A

Free nerve endings

46
Q

If two stimuli are applied to one receptive field, is 1 point or 2 points felt?

A

1 point

47
Q

When two stimuli are placed in two different receptive fields, is 1 point or 2 points felt?

A

2 points

48
Q

When two stimuli are applied to one receptive field and the overlap between two receptive fields, is 1 point or 2 points felt?

A

2 points

49
Q

When two stimuli are applied to the overlap between two receptive fields and a region where there is no receptive field present, is 1 point or 2 points felt?

A

1 point

50
Q

When a stimulus is applied to the overlap between two receptive fields, sensory information is sent down two lines to the brain. So do you feel two stimuli when this occurs?

A

No, only feel 1 stimulus even if both receptors are becoming active
- Brain is able to detect that this is only one point because of the timing and intensity of the stimulus.

51
Q

Which regions have the smallest two point threshold in the body?

A

Fingers, thumb, palm, forehead, cheek, nose, upper lip, hallux (big toe)

52
Q

Which regions have the largest two point threshold in the body?

A

Forearm, upper arm, shoulder, breast, belly, thigh, back, calf

53
Q

Describe the receptor activity of Merkel’s discs as fingers run over Braille writing

A
  • Located close to the surface
  • Similar replica activity to bumps
  • Really good at distinguishing between Braille letters
54
Q

Describe the receptor activity of Meissner’s corpuscle as fingers run over Braille writing

A

A little bit less clear than Merkel discs, but still good at distinguishing between letters

55
Q

Describe the receptor activity of Ruffini endings as fingers run over Braille writing

A

Still a little bit active, but not very good at making the distinction between letters

56
Q

Describe the receptor activity of Pacinian corpuscles as fingers run over Braille writing

A
  • Get almost universal activation
  • Detect vibration, and paper isn’t smooth, so as you drag your finger across the page, you will get vibration
  • Blank spots probably from smooth parts of paper -> causes finger to lift
57
Q

What is the dorsal root ganglion (aka posterior root ganglion)?

A

Connects receptors to spinal cord with a unipolar cell (responsible for transmitting sensory information from the periphery to the central nervous system)
- First part of unipolar cell: axon initial segment, that has stretch-activated channels. If stretch-activated channels allow for depolarization + AP threshold to be met, AP is sent down unipolar cell.
- Dorsal root ganglion cell present (bulge near spinal cord where all the cell bodies of teh somatosensory receptors are located)

58
Q

Dermatomes

A

Represent the spinal segments where all the sensory information from that patch of skin travel to.