Sensory Physio Flashcards

1
Q

Meissner Corpuscle

A
  • RA
  • Tap/flutter
  • Small RF
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2
Q

Hair follicle receptor

A
  • SA or RA

- Motion and direction

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3
Q

Pacinian Corpuscle

A
  • RA
  • Vibration
  • Large RF
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4
Q

Merkel Disc

A
  • SA
  • Touch and pressure
  • Small RF
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5
Q

Ruffini Corpuscle

A
  • SA
  • Skin Stretch
  • Large RF
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6
Q

Pathway of Pre-Synaptic Inhibition

A
  1. GABAergic influx of Cl- into axon
  2. Hyperpolarization occurs
  3. Less Ca2+ enters cytosol
  4. Less NT released
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7
Q

Why do we have pre-synaptic inhibition?

A

To improve brain’s ability to localize the signal

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8
Q

Neurons stacked above and below?

A

Fundamentally similar

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9
Q

Neuronal columns side-by-side

A

Significantly different (same body region, different modality)

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10
Q

What layers of cortex are important for sensory input?

A

III and IV are enlarged in primary sensory cortex/ main site of termination of axons from thalamus

  • Main output neurons are pyramindal cells
  • *IV is first area to receive input
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11
Q

Primary Somatosensory Cortex

A
  • @ post-central gyrus
  • Brodmann Areas 3, 1, 2
  • First area for most cutaneous sensations
  • Integration of information for position sense as well as size and shape discrimination
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12
Q

Secondary Somatosensory Cortex

A
  • @ wall of Sylvian fissure
  • receives input from S1
  • Comparisons b/w objects, different tactile sensations/determining whether something becomes a memory
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13
Q

Characteristics of parieto-temporal-occipital association cortex (PTO)

A
  • High levels of interpretation of sensory inputs
  • Receives input from multiple sensory areas
  • Analyzes spatial coordinates of self in environment
  • Names objects
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14
Q

What typically characterizes corticofugal signals?

A
  • Travels from cortex to lower relay stations in thalamus, medulla or SC
  • Controls intensity of sensory sensitivity
  • Typically inhibitory and suppresses sensory input
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15
Q

Doctrine of specific nerve energies

A

No matter where stimulated, sensation that occurs is determined by nature of sensory receptor in periphery connected to that pathway

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16
Q

Law of projections

A

No matter where stimulated, perceived sensation arises from origin of the sensation

17
Q

Pain vs. nociception

A

Pain is just an experience, while nociception is an actual or potential injury that leads to a neural signal

18
Q

Peptidergic free nerve endings

A
  • Substance P and CGRP
  • Responsive to NGF
  • Most of visceral afferents
  • 1/2 of cutaneous afferents (chronic inflammation/visceral pain)
19
Q

Non-peptidergic free nerve endings

A
  • No neuropeptides expressed
  • Responsive to GDNF
  • Few visceral afferents
  • 1/2 of cutaneous afferents (diabetic neuropathy)
20
Q

TRPV1

A

Capsaicin

50*C

21
Q

TRPA1

A

Allyl isothiocyanate

10*C

22
Q

TRPM8

A

Methyl

20*C

23
Q

Other signaling modalities for noxious stimuli

A
  • Nav 1.7
  • P2X
  • ASIC
  • SP and CGRP
  • Histamine
  • Bradykinin
24
Q

Na v 1.7

A

Mechanosensitive sodium channel

- Mutations responsible for both pain-insensitivity and paroxysmal extreme pain disorder

25
Q

P2X

A

Activated by ATP

26
Q

ASIC

A

Activated by H+

27
Q

What do C fiber terminals release?

A

EAAs and SP/CGRP

28
Q

What do Ad fibers release?

A

EAA

29
Q

What do these EAA bind?

A

AMPA receptors

30
Q

Bradykinin pathway

A

Bradykinin released in pro-inflam. states – activates nociceptors – NGF upregulated – more pain

31
Q

Role of insular cortex in nociception

A
  • Interpretation of nociception
  • Contributes to autonomic pain response
  • Integrates all signals related to pain
  • Damage can cause asymbolia
32
Q

Amygdala role in pain

A

Emotional component to pain

33
Q

Skin pain stimuli

A

Thermal
Mechanical
Chemical

*FP and SP

34
Q

Joint/bone pain stimuli

A

Mechanical
Chemical

*Dull/achy pain

35
Q

Muscle pain stimuli

A

Mechanical
Chemical

*FP and SP

36
Q

Viscera pain stimuli

A

Mechanical
Chemical

*poorly localized