Senses: Head and Neck Flashcards

1
Q

Describe the Anatomical and Functional organisation of the TMJ joint

A

-Connects the mandible to the temporal bone
-Attachments at the mandibular fossa of the temporal bone and the condylar process of the mandible
-Modified hinge synovial joint containing fibrocartilage rather than hyaline
-2 cavities separated by an articular disc filled with synovial fluid
-The joint is articulated primarily by the muscles of mastication which are innervated by CN 5
-The joint allows for protrusion, depression, retraction, elevation and lateral movement of the mandible.
-Stabilised by 2 extrinsic and 1 intrinsic ligament
oLateral ligament (intrinsic)- the zygomatic process of the temporal bone to the neck of the mandible
oSphenomandibular ligament- spine of the sphenoid bone to the lingula on the ramus of the mandible
oStylomandibular ligament- styloid process of the temporal bone to the angle of the mandible
oThese ligaments protect against posterior dislocation but not anterior (at risk during depression movement

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2
Q

Discribe muscles of Mastication

A

Masseter: Powerful elevator
superficial heads: inferior surface of the zygomatic bone + deep heads: maxillary process of the zygomatic bones> angle and ramus of mandible.
anterior trunk of the mandibular branch of the trigeminal nerve (CN 5)
Temporalis: Retraction and elevation
Temporal fossa> coronoid process of the mandible
anterior trunk of the mandibular branch of the trigeminal nerve (CN 5)
Lateral Pterygoid: protrusion of the jaw as well as assisting with lateral movement
upper heads: roof of the infratemporal fosses + greater wings of the sphenoid bone + lower heads: lateral surfaces of the lateral plates of the sphenoid bone> pterygoid fovia of the condylar processes of the mandible
anterior trunk of the mandibular branch of the trigeminal nerve (CN 5)
Medial Pterygoid: production of lateral (side to side movements) as well as weak elevation of the mandible
superficial heads: medial surface of the lateral plates of the pterygoid + pyramidal processes at either side of the sphenoid bone + superficial head: tuberosity of the pyramidal processes of the maxillae> angle of the mandible
Main trunk of the mandibular branch of the trigeminal nerve (CN 5)

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3
Q

Describe the anatomy and function of the pharynx

A

-Pharynx can be split into 3 separate sections
oNasopharynx which is connected anatomically to the nasal cavities.
oOropharynx which is connected anatomically to the oral cavity.
oLaryngopharynx (larynx) which connected to the oesophagus and trachea
-Posteriorly it can be observed that there is a stiff pharyngobasilar fascia which holds the nasopharynx open.
-There are 3 constrictor muscles within the pharynx which move food bolus through the pharynx towards the oesophagus. These are superior, middle and inferior. These are innervated by the Vagus nerve (CNX)
-The inferior pharyngeal constrictor has a lower circular band known as the cricopharyngeus that forms a sphincter around the upper oesophagus which prevents air being drawn into the stomach.
-The pharynx also contains elevator muscles which descend from the base of the skull and fan out to the inner surface of the pharynx. Some also send fibres to the thyroid cartilage ensuring simultaneous elevation of the pharynx and the larynx during swallow
oPalatopharyngeus: Elevates the pharynx and larynx and draws soft palate downwards (CNX Vagus)
oStylopharyngeus: Originates form the styloid process and elevates the pharynx and larynx. Supplied by (CN IX Glossopharyngeal nerve)
oSalpingopharyngeus: Originates from auditory tube, elevates the pharynx and larynx. Helps open the auditory tube for equalisation of the inner ear during swallow

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4
Q

Describe the phases of swallowing

A
  • Oral Phase: food bolus formed in the oral cavity by the action of chewing and concurrent tongue movements. Bolus pushed into oropharynx by tongue. The soft palate closes the nasopharynx.
  • Pharyngeal phase: Contraction of constrictors and elevation of soft palate to receive food. Pushed towards oesophagus. Epiglottis closes the laryngeal inlet to protect the airway. Elevation of the hyoid muscles and then depression of hyoid and larynx following elevation.
  • Oesophageal phases: Inferior constrictor contracts the upper oesophageal sphincter allowing the food bolus into the oesophagus. Peristalsis occurs.
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5
Q

Describe the Suprahyoid muscles

A
  • Mylohyoid: mylohyoid line of mandible>hyoid ad fibres opposite mylohyoid. Elevatd the hyoid and floor of mouth CN 5 (3)- inferior alveolar branch
  • Digastric: Anterior and posterior bellies. Anterior: medial aspect of mandible, Posterior: medial aspect of mastoid process> hyoid. Anterior= raises hyoid and opens mouth, posterior belly elevates and retracts the hyoid. Anterior same as mylo and posterior digastric branch of CN VII
  • Stylohyoid: styloid process>hyoid. Pulls hyoid upwards and supplied by CNII Facial
  • Geniohyoid: located superior to mylo.
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6
Q

Describe the Infrahyoid muscles

A

Infrahyoid

  • Sternohyoid: posterior aspect of sternoclavicular joint and manubrium> hyoid. Depresses hyoid after elevation during swallow
  • Omohyoid: Superior belly: intermediate tendon and inserts into hyoid attaches with fascial sling. Depresses and flexes hyoid.
  • Thyrohyoid: Thyroid cartilage> hyoid. Depression and can raise larynx when hyoid is fixed
  • Sternothyroid: Posterior aspect of manubrium and inserts into thyroid cartilage. Draws larynx down.

Sternohyoid, omo and sternothy are innervated by C1-3. Thyro= C1 via CN XII

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7
Q

Describe the anatomical structure, irrigation and innervation of the nasal cavity

A
  • There are two nasal cavities separated by a septum.
  • Nasal cavity contains nasal concha which help spin and moisten air. There are three concha- superior, middle and inferior. The spaces between these choncha are known as the superior, middle and inferior meatus.
  • Innervation is supplied by olfactory nerves which leave the brain through the cribriform plate. These nerves arrive from the olfactory bulb (Olfactory nerve CN1)
  • These nerves are associated with sensory receptors in the olfactory mucosa
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8
Q

Describe the paranasal sinuses and their drainage

A
-Hollow pockets filled with air which aid ‘air conditioning’ and lighten the skull
oFrontal sinus (frontal bone): drains via the frontonasal duct into the lateral wall of the nasal cavity (hiatus semilunaris) 
oEthmoid sinus (ethmoid bone): 3: anterior (drains into hiatus semilunaris, middle (ethmoid bulla) and posterior (superior meatus).
oMaxillary sinus (maxillary bone): hiatus semilunaris inferior to opening of frontal sinus. Drainage of frontal can enter maxillary causing spread of infection.
oSphenoidal sinus (Sphenoid bone): drain onto the roof of the nasal cavity and have associations with the pituitary gland (it can be accessed through the sinuses in surgery
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9
Q

What is the anatomical and functional organisation of smell

A
  • Olfactory cranial nerve branches into cranial nerves which pass through the cribriform plate and associate with smell receptors in the nasal cavity
  • There are medial and lateral olfactory pathways in the olfactory bulb. The Lateral Olfactory tract utilises mitral cells which send signals to the piriform cortex, amygdala and entorhinal cortex in the brain which lead to the prefrontal cortex and hippocampus (olfactory corticles). The medial olfactory pathway involves tufted cells which provide information to the basal forebrain and limbic structures which provides emotional association with smells
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10
Q

What is the anatomy of the oral cavity

A

-Expands from the oral fissure anteriorly to the oropharyngeal isthmus posteriorly
-Split to upper and lower dental arches
-Oral vestibule is the area between the teeth and the lips
-The roof of the mouth is separated into the hard and the soft palates. The hard palate is located in the anterior portion and separates the oral and nasal cavities. It is a bony palate which is covered superiorly with respiratory mucosa and inferiorly with oral mucosa. The soft palate is a posterior continuation of the hard palate. It is a muscular structure and acts as a valve that can lower to close the oropharyngeal isthmus and elevate to separate the nasopharynx from the oropharynx.
o Muscular diaphragm – comprised of the bilateral mylohyoid muscles. It provides structural support to the floor of the mouth, and pulls the larynx forward during swallowing.
oGeniohyoid muscles – pull the larynx forward during swallowing.
oTongue – connected to the floor by the frenulum of the tongue, a fold of oral mucosa.
oSalivary glands and ducts.
-The oral cavity contains 2 arches posteriorly.
oThe palatoglossal which is the most anterior and is the site of attachment of the uvula
oThe palatopharyngeal arch which sit posteriorly
-The palatine tonsils sit between each side of these arches

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11
Q

Describe the surface area of the tongue

A

-The tongues surface contains different types of papillae that increase surface area for taste receptors.
oFungiform (most anterior)- rounded appearance
oFiliform (middle)- spiky appearance
oVallate (Most posterior)- inwards appearance.
-The terminal sulcus divides the tongue into an anterior 2/3 and posterior 1/3
oAnterior 2/3 taste is provided by CNVIII and sensory by CNV (3)
oPosterior 1/3 taste and sensory by CNIX

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12
Q

Describe the extrinsic muscles of the tongue

A
Syloglossus:
Retracts and elevates tongue
Genioglossus
Protrudes, depresses and pulls tip of tongue back and down
Hyoglossus
Depresses and Retracts
Palatoglossus
Elevates posterior aspect of tongue
- All are innervated via the hypoglossal nerve CN XII but the palatoglossus which is innervated by the vagus nerve CNX
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13
Q

Which pathway handles taste information?

A
  • Ventroposteromedial pathway deals with taste
  • Nucleus of thalamus relays information to the gustatory cortex which encompasses the anterior insula and frontal operculum of the frontal and insular lobes.
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14
Q

What are the neural pathways serving pain and nociception

A

-The main pathway involved in pain reception is the spinothalamic tract. It incorporates 2 different types of neurons AB and C fibres. These produce primary and secondary types of pain. Primary pain is fast acting and occurs in the myelinated AB fibres. The secondary pain response is by the C fibres which take longer to react (unmyelinated)- 2nd wave of pain. See more in neuro block.

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15
Q

What are some factors which influence pain experience?

A

-Hyperalgesia is the term used to describe increased pain
oResult of damage to tissue which causes nociceptors to be hypersensitised
oIt may involve changes to the CNS- ‘central sensitisation’ where activity is exaggerated. Inputs from low-threshold mechanoreceptors are perceived as a painful stimulus.
oDecreased threshold for sensitisation due to increase in chemicals such as bradykinins (released from damaged tissues- activates nociceptors), Substance P (released from peripheral terminals of nociceptors. Dilates blood vessels, may activate mast cells), postaglandins (synthesised from cyclo-oxygenises from damaged lipid membranes. This sensitises nociceptors, rather than activating directly).
-Conversely there are conditions which decrease sensitivity to pain. A study carried out on a young boy with a condition caused by dysfunction in an SCN9A channel. This meant he could not experience pain and had very little understanding of it. This resulted in his death at the age of only 10.
-Some analgesics work by inhibiting postglandin synthesis which in turn decreases sensitivity

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16
Q

Discribe the basic sensory endings in muscles

A

-Muscle Spindles
o Involved in fine control
o They are large, complex mechanoreceptors
o Located in muscle (dense population of muscle spindles within skeletal muscle)
o Have 2 sensory endings: primary is very fast and responds to movement and stretch. Secondary is slower and comments on length of muscle.
-Golgi Tendon Apparatus
o Located in tendons
o Also large mechanoreceptors
o Large density sensory fibres encased in connective tissue
o Respond to active force within tendons
-Fine Afferents
o Group 3 and 4 fibres which are highly myelinated as well as unmyelinated
o They are difficult to identify with a light microscope and it is difficult to make electrical recordings.
o They are believed to be polymodal (several functions such as mechanoreceptors, nociceptors etc…)

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17
Q

Describe Joint Receptors

A
  • Located in the connective tissue of joint capsules, ligaments and fat pads
  • They have a similar composition to golgi tendons, Ruffini endings and Pacinian corpuscles). They contain free nerve endings which respond to changes in force within the connective tissue. They can be both rapid and slow adapting.
  • Utilise mechanotransduction- convert movement into electrical signal. Triggers AP in response to stretch, deformation, change in sarcomere length, stretch sensitive channels.
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18
Q

What are the definitions of Proprioception, position sense and kinaesthesis

A
  • Proprioception: Signals contributing to conscious and subconscious motor control.
  • Position sense: (Stataesthesis) Conscious awareness of relative positions of our body
  • Kinaesthesis (movement sense): awareness of joint movement, sense of movement, position and direction.
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19
Q

What evidence is there that proprioception is important to movement?

A

-Ian Waterman: patient with a selective large fibre sensory neuronopathy. No sensory feed-back from muscle, skin or joint from below the neck. Has relatively uncoordinated movements

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20
Q

Describe how discharge frequency of receptors may be related to proprioception

A

-Slowly and rapidly adapting receptors exist in joint capsule and ligaments
- 4 types:
o 1- Ruffini (SA)
o 2- Paciniform (RA)
o 3- Golgi (SA)
o 4- Free nerve (SA)
- RA joint receptors can signal occurrence and speed of movement: discharge rate of single Ruffini join afferent in response to movement in different directions. Can also signal contact
-SA joint receptors produce a discharge related to joint position (different discharge for different position. Signal maintained contact.
-These look to be providing sensory information on position and velocity of movement which is of importance in proprioception

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21
Q

How does information from spindles, joints etc… work with proprioception?

A

-Can only really be observed in human studies.
-Joint receptors
o Joint replacement operations or blockage of articular afferents with local anaesthetics- moderate loss of position sense
o Electrical stimulation of some single joint afferents evokes sensations of pressure, stress or joint movement
-Cutaneous Receptors
o Electrical stimulation of a small proportion of SAII afferents during microneurography, evokes a sensation of joint movement: others only tactile sensation.
-Muscle Spindle receptors
o Tendon pulling experiments: pulling of tendons exposed conscious humans to stretch muscle without producing movement- evokes some sense of movement
o Effects of muscle vibration (proximal joints)
 Think their arms are at the same position (moved)

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22
Q

Describe the Anatomy of the larynx including cartilages, membranes and ligaments.

A
  • Organ located in the anterior of the neck
  • Structure is primarily cartiligenous and is held together by a series of membranes and ligaments. Its structure is mainly that of a cartilage skeleton.
  • The larynx is suspended in the anterior portion of the neck by the hyoid bone (a small floating bone consisting of a body and 2 lesser and greater horns). It is suspended by the thyrohyoid membrane
  • It opens superiorly to the lower segment of the pharynx and inferiorly to the trachea
  • It is covered anteriorly by the infrahyoid muscles and laterally by the lobes of the thyroid gland.
  • It consists of the supraglottis in which the the epiglottis is located (a leaf shaped covering which acts like a valve preventing food enetering the airways). It ends at the vestibular folds (false vocal folds)
  • The glottis which houses the vocal cords. The openeing between the vocal folds is known as the rema glottis
  • ## The subglottis is from the inferior border of the glottis to the inferior border of the cricoid cartilage.
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23
Q

Describe the musculature of the larynx in terms of innervation and movement: Extrinsic muscles

A

Suprahyoid and Infrahyoid

- suprahyoid and stylopharyngeus lift larynx while infrahyoid depresses

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24
Q

Summarise the main cartilages of the larynx

A
Unpaired
Thyroid cartilage
- form laryngeal prominance
Cricoid cartilage
Epiglottis
Paired
Arytenoid
- attachment of vocal ligament
Corniculate
- articulate with arytenoid
Cuniform
- strengthens ary-epiglottic folds
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25
Q

Describe the musculature of the larynx in terms of innervation and movement: Intrinsic muscles

A

Act on individual components
- control shape of rima glottis. All but cricothyroid are innervated by inferior laryngeal nerve (can be damaged).
Cricothyroid: stretches and tenses vocal ligaments. External laryngeal nerve. Important for forceful speech.
Thyroarytenoid: relaxes vocal ligament. Attaches to arytenoid.
Lateral cricoarytenoid: Adducts vocal folds
Transverse and Olblique arytenoids: adducts arytenoid cartilages spans them.

26
Q

Summarise Phonation

A

To produce speech the rima glottis must be closed (transverse arytenoid and lateral cricothyroid muscle). Air pushed through these closed folds will produce vibrations. Movement of the lips, teeth and tongue + variations in force by the diaphragm words can be articulated. Alternating the tension of the vocal folds produces different pitches.

27
Q

Summarise basic terminology for analgesics

A

Opium: extract juice from poppy
Opiate: Natural compounds found in the opium poppy
Opioid: any substance, whether natural or endogenous and synthetic, that produces morphine like effects
Narcotics: old-term for opiod drugs, reflects sleep inducing properties

28
Q

Describe the ascending pathway of pain reception

A
  • Primary afferents project to dorsal horn of spinal cord
  • Synapse on spinothalmic tract neurons (2nd order) neurons
  • Axons of 2nd order neurons cross midline and project up to thalamus.
  • Synapse on 3rd order neurons that project to the cerebral cortex
29
Q

Describe endogeneous opioids

A
  • Opoids which have high affinity binding sites
  • Enkephalins: Met-enkephalins, Leu-enkephalin (common Tyr-Gly-Gly structure)
  • Part of a wide family of peptides incuding endorphins such as morphine and dynorphins.
  • Common feature is an amine group seperated from a phenyl ring by 2 C atoms
30
Q

Mechanisms of morphine

A
  • Act as agonists on opiod receptors
  • reduce neuronal excitability
  • Can increase activity via disinhibition of inhibitory interneurons
31
Q

Describe strategies used to improve efficacy and specificity of morphine as an analgesic

A
  • Synthetic compound analogues of morphines have been created which have groups removed.
32
Q

Define different opiod receptor types and their mechanisms

A

GPCRs; coupled to Gi/Go proteins

  • block adenylate cyclase
  • activate potassium channels
  • inhibition of calcium channels
  • Activation of MAPK cascades
Different types are
Mu- receptor for endorphins
Delta- receptor for enkephalins
Kappa- receptor for dynorphins
ORL1- receptor for nociceptin
33
Q

Opiod agonists and antagonists

A

Pure agonists: methadone, high affinity for mu receptors, low affinity delta and kappa
Partial agonists: morphine, preferential effects at mu
Mixed agonists/ antagonists: pentazocine, agonists at kappa, anatagonists at mu
Antagonists: naloxone, antagonists at mu, delta and kappa.

34
Q

How do analgesics work on the brain

A
  • Mediated in the periphery, spinal cord and brain
  • inhibit spinal reflexes and transmission of nociceptive impulses through the dorsal horn
  • Cause localised release of endorphins in the brain and spinal cord.
  • Also affect descending pathways: act on raphe nucleus to induce the release of 5HT in spinal cord
35
Q

Pharmalogical effects of morphine

A

CNS- mediated analgesia, euphoria, respiratory depression, depression of cough reflex, nausea
Non- CNS: reduced GI-motility, itching,, bronchoconstriction, hypotension

36
Q

Cannaboids for pain relief

A
  • Acts on CB1 receptors to relieve acute, inflammatory and neuropathic pain in animal models
37
Q

Explain the skeletal framework of the eye orbit.

A

The orbit of the eye is made up of 6 bones of the skull. These are the sphenoid bone, ethmoid bone, lacrimal bone, maxillary bone, zygomatic bone and the frontal bone.

38
Q

Describe the fissures and openings within the eye sockets and their contents.

A

There are two fissures located in the sockets of each eye:
The superior orbital fissure
- The occulomotor nerve, trochlear nerve, branches of the opthalmic nerve, abducens nerve and the superior opthalmic vein.
Optic Canal
- Optic nerve and opthalmic artery

39
Q

Summarise the extrinsic muscles of the eyes, their function and innervation

A

There are 8 muscles involved in the articulation of the eyes.
- Levator Palpabrae Superioris
Lesser wing of sphenoid> skin and tarsal plate of upper eyelid. Blinking. occumotor nerve
Rectus Muscles: all arise from the tendonous ring and insert into the sclera
- Superior rectus
elevation, adduction and medial rotation: Occulomotor nerve
- Inferior rectus
depression, adduction and lateral movement. Occulomotor nerve
- Medial rectus
Adduction. Occulomotor
- Lateral rectus
Abduction. Abducens
Rectus muscles: angular approach
- Superior Oblique
Depresses, abducts and medially rotates. Trochlear Nerve
- Inferior Oblique
Elevates, abducts and laterally rotates. Occulomotor

40
Q

Explain the anatomical organisation of the eyeball

A

Can be divided into fibrous, vascular and inner layers
Fibrous: Outermost layer containing sclera and cornea which are continuous with each other.
Vascular: Choroid which is a layer of connective tissue and vasculature to nourish the fibrous layer. Ciliary body which contains ciliary muscles and processes which control movement of iris. Iris: circular structure with circular aperture in the centre (size can be controlled)
Inner Layer: Contains retina which is composed of a neural layer containing photoreceptors laterally and posteriorly, and a pigmented area which continues all around the eye (unlike the neual layer) and is a non-visual area.

41
Q

Describe the blood supply and innervation of the eyeball

A

Recieves blood from the opthalmic artery. The innervation is primarily via the optic nerve. Glaucoma refers to a group of eye diseases which cause damage to the optic nerve.

42
Q

Explain the anatomy of the ear.

A

The ear consists of 3 seperate chambers.
- The outer ear: External acoustic meatus marks the opening of the outer ear. Associated with several external structures of the ear such as the auricle. Ends at the tympanic membrane (ear drum). Composed of cartilage and bone, it leads sound waves towards the middle ear.
- The middle ear
Houses the ossicles of the ear (Maleus, Stapes and Incus. These mechanically transmit sound. Connected to the pharynx via the auditory tube.
- The inner ear: housed in the petrous part of the temporal bone. Contain the cochlea which transmit sound into electrical signals to be transported by the vestibulocochlear nerve and semi-circular canals which sense motion.

43
Q

Describe the histology of the ear

A

Outer ear: Epidermis: stratified epithelium. dermis: hair follicles, sebatious glands etc…
Tympanic membrane: outer layer contains stratified squamous epithelium (skin), middle contains connective tissue and inner contains a simple cuboidal mucous membrane

44
Q

Summarise the anatomy and functioning of the organ of corti in the cochlea

A

The boni labyrinth containing the cochlea and semicircular canals contains a fluid known as perylinth in which a membranous labyrinth is suspended containing endolynth.

45
Q

Summarise the transmission of sound in the ear

A

Sound is transmitted through the outer ear and reaches the tympanic membrane causing movement of the ossicles which is then transferred to the inner ear where the energy is transfered into electrical signals which provide information on movement and sound.

46
Q

Give an account of the 2 components of CN VIII, vestibulocochlear nerve and locate the site where it exits the brainstem

A

Exits the brainstem at the pons and along with the facial nerve and the labyrinthine artery will leave via the internal acoustic meatus. The Facial nerve travels through the inner ear giving off taste and parasympathetic branches
The vestibular part of CNVIII provides information on balance from the semicircular canals whereas the cochlear part provides information on sound.

47
Q

Describe the roles of the ear structures in hearing

A

External ear: external acoustic meatus boosts sound pressure into the tympanic membrane.
Middle ear: tympanic membrane to oval window increases pressure. large window to small window
Inner ear: amplication of sound waves into a neural signal (small hair cells in cochlea) and mechanical frequency analysis

48
Q

Describe the auditory cortex and it’s role in hearing

A

Auditory cortex is located in the superior temporal gyrus of the temporal lobe.
- Ipcilateral projections into the cochlear nuclei
- Tonotopy occurs in the cochlear nuclei
-

49
Q

Describe the auditory cortex and it’s role in hearing

A

Auditory cortex is located in the superior temporal gyrus of the temporal lobe.
- Ipcilateral projections into the cochlear nuclei
- Tonotopy occurs in the cochlear nuclei
- There are multiparallel ascending pathways with a high level of bilateral connectivity
- They branch into the inferior colliculus
- Superior olive recieves input from both ears.
All auditory nuclei except the cochlear nuclei input from both ears.
- Synapse onto the medial geniculate complex of the thymus which then sends projections to the auditory cortex.

50
Q

Describe different mechanisms for horizontal localisation of sound.

A

Low frequencies: interauranal TIME differences: medial superior olive.
High frequencies: interauranal INTENSITY differences: lateral superior olive and medial nucleus of the trapezoid body
Both are supported by parallel pathways originating from the cochlear nucleus.

51
Q

Describe interaunal time difference detection in humans

A

MSO (medial superior olive)

  • Neurons are coincidence detectors
  • Anatomical differeces in connectivity between 2 excitatory inputs means that each MSO can be sensitive to a sound source in a particular places.
  • Only small frequencies as it requires phase-locking information from the periphery
52
Q

Describe ineraunal frequency difference detection in humans

A

MSO (medial superior olive) and MNTB (medial nucleus of trapezoid body).
Each LSO recieves excitatory input from ipselatoral enteroventral cochlear nucleus and an inhibitory input via the contrelateral ear via and inhibitory neuron in the MNTB.
Interaction of excitatory and inhibitory stimuli results in a net excitation of the LSO on the same side of the body at the same side as the source.

53
Q

Describe the roles of each of the brainstem nuclei in audition.

A

Primary auditory cortex: compiling auditory information
MGC (thalamus): Convergence of inputs. Mediates detection of spectral and temporal combinations of sounds that are required for processing speech.
Inferior Colliculus (midbrain): Localisation of sounds and encoding of sounds with complex temporal pattern (speech).
Lateral Lemnisus (pons): encoding of temporal aspects of sound, such as duration.
Superior Olive (mid pons): Localisation of sources of sound signals based on interaural time and intensity differences

54
Q

Localisation of auditory cortex

A

6 cortical layers
4: input from MGC
5+6: send feedback projections to IC and MGC respectively
Primary auditory cortex: basic sounds, speech, loudness.
Secondary Auditory cortex: specialised processing of harmonic, melodic and rhythmic patterns

55
Q

Define Basic Structures of the Vestibular receptor system.

A

Peripheral portion of the vestibular system:
inner ear structures, detect angular and linear acceleration, report information about motion if head and body.
Central portion: Vestibular nuclei, extensive connections with brainstem and cerebellum structures. Control of postion and gaze, head and body during movement

56
Q

Relate anatomical organisation of the semicircular canals and otolith organs to sensitation of movement.

A

Otolith Organs
- Saccule (vertical) and utricle (rapid lateral displacement)
- responsible for static equilibrium and linear acceleration of the head
Semicircular canals
Respond to rotational accelerations of the head.
- copula distorted by movement of endolynth. Depolarise and hyperpolarise in response to orientation

57
Q

Outline Vestibular pathways and functions

A

Cerebelum
- direct projections from the vestibular nerve and through the vestibular nuclei in the pons
- corrective adjustments sent to the motor cortex: balance and posture
Nuclei of cranial nerves
- Occulomotor, trochlear and abducens, vestibulo-occular reflex: coordination of eye movements to fix gaze while movement
Nuclei of accessory nerves
- spinal accessory nerve
- Vestibulospinal traces (medial and lateral)
- Control head movement and posture to maintain equilibrium
Ventral posterior nucleus of tha thalamus and cortical vestibular areas.
- Thalamic relay
- Awareness of position and movement

58
Q

Describe the vestibulooccular reflex.

A

When head rotates both eyes move in the opposite direction due to the contraction of the lateral rectus and medial rectus muscles triggered by the semilunar canals.
- Descending projections from the vestibular nuclei to the spinal cord controlling for adjustments of the head (Vestibulo Cervicale- reg of position and control of neck muscles) and the body (Vestibulo Spinal- balance and maintenance of posture))

59
Q

Describe the development of the pharyngeal arches.

A

Key structures to face and neck development
- 5 arches ; 1,2,3,4,6
- Develop around week 4 and 5
- Mesenchyme is the mesoderm and everything inside it. Each mesenchymal bulge contains 1 artery, 1 nerve (crANIAL) and one skeletal element
-The indentations are called the pharyngeal cleft and the inside is the pharyngeal pouch.
Mesenchyme origin in face and head development
-Comes from paraxial mesoderm and neural crest
-Everything that surrounds the brain, •Connective tissue of posterior head •Meninges caudal to prosencephalon •All voluntary cranio-facial muscles from p.m
Neural crest contributions
-Depends where they start, develop into different structures
-Prosencephalon neural crest cells migrate to rostral part of head and give rise to certain parts of the face
-Towards the hindbrain these cells are more complex. Become the pharyngeal arches
Back to pharyngeal arches
-1st p arch forms the mandible, the incus and the malleus, muscles of mastication
-2nd forms the stapes, styloid process and upper part of hyoid bone, muscles of facial expression
-3rd forms lower hyoid bone, stylopharyngeus
-4th and 6th v close develop into larynx

Everything links to the cranial nerves
-First arch; trigeminal
-2nd facial
-3rd glossopharyngeal
-4the and 6th vagus
Arteries
-Not v important. Some disappear over time and the rest remain
Pouches
-The 4th pouch gives the superior parathyroid
-Whereas the 3 gives the inferior parathyroid
Thyroglossal duct
-From the foramen caecum the thyroid will develop and slowly migrate downwards. Held in pace by the thyroglossal duct. The duct disappears but this can persist and creates an infected cyst

60
Q

Explain the development of the face and head

A

-Neural crest cells form the frontonasal prominence
-Maxillary prominence and mandibular prominence come from the 1st phar arch
What goes wrong if things don’t fuse
-Neural crest cells very vulnerable. They help with development of the face
-Fetal alcohol syndrome

Palate

  • Primary palate and secondary palate
  • 1y comes from maxillary processes
  • 2y palate makes 1y plate stronger. This comes from palatine cells the purple cells (nasal prominences)
  • If the 1y and 2y don’t form we end up with cleft palate