Senses Flashcards
Basics of the senses (5)
Stimulus from the physical/chemical environment»_space;> reception»_space;> transduction»_space;> encoding and transmission»_space;> perception
How are sensory systems organised? (3)
Labelled lines - 1 pathway per modality
Properties (e.g. location) of stimuli are mapped onto brain structures e.g. retinotopic, chemotopic and tonotopic maps,
Firing properties code for everything else
Strength of stimulus can be encoded by what? (2)
Spike rate/onset
Number of axons activated
What is the macula responsible for? (1)
Central vision
What is the fovea? (1)
Central/thinner region of retina
High resolution
What is the optic disc? (2)
Origin of blood vessels
Where optic nerve axons exit the eye (blind spot)
Where is light focused in the eye? (1)
Back of the retina
Where does phototransduction occur? (1)
In outer segment of photoreceptors
What happens to photoreceptors in the dark? (1)
Depolarise
Release glutamate
What are the two different photoreceptors? (2)
Rods - nighttime
Cones - daytime and colour
What is the main visual pathway in mammals? (3)
Retina»_space;> Lateral Geniculate Nucleus (in the thalamus)
»> Primary visual cortex
What is in the cortical module V1? (2)
Neurones that represent different orientations of stimuli
Neurones that represent different input
What is sound? (1)
A series of changes in a pressure which form a wave
What are the auditory ossicles? (6)
Malleus = hammer
Incus = anvil
Stapes= stirrup
What happens in the middle ear at the oval window? (2)
Transmit pressure waves in air into pressure waves in liquid
This results in ~22x greater force at the oval window
What is the organ of corti? (3)
Lies within the cochlear duct (Scala media)
Vibration causes the organ of corti to move up and down against the tectorial membrane
It is the inner hair cells within the organ of corti that are the sensory receptors transducing deflections of their cilia
How does mechano-electrical transduction occur? (1)
When stereocillia are perturbed we get mechano-electrical transduction
Inner hair cells (4)
The endolymph of the cochlear duct (Scala media) is high in K+
Movement of stereocillia opens K+ channels causing depolarisation
Which opens Ca2+ channels resulting in transmitter release onto spiral ganglion cells
The axons of spiral ganglion cells form the auditory nerve
What is the main auditory pathway? (5)
Cochlea
Cochlear nucelus
(brainstem)
Inferior colliculus
Medial Geniculate Nucleus
(in the thalamus)
Primary Auditory cortex
What are 3 sensory systems associated with the nose & mouth? (3)
Olfactory (smell)
Gustatory (taste)
Trigeminal (crispiness/ some chemicals)
Where are olfactory sensory neurones located? (2)
In the olfactory epithelium which lines the nasal cavity below cribriform plate
What happens to odourants in the nose? (2)
Odourants enter nasal cavity & dissolve in mucus secretion
Dissolved odourants bind to receptors on the cilia of olfactory sensory neurons
Describe olfactory transduction (4)
Odourants bind to G-protein coupled receptors on cilia
Activation leads to production of cAMP
Leads to depolarisation as:
cAMP binds to and opens cation (Ca2+ & Na+) channels
Ca2+ opens Cl- channels -> Cl- efflux
Encoding and transmission in the olfactory system (3)
Olfactory sensory neurons send their axons through the cribriform plate to synapse in the olfactory bulb
Olfactory bulb is 1st stage of olfactory processing
Signals are then sent directly to many brain areas
How does the olfactory system target the cortex (4)
The olfactory system targets cortical and subcritical structures directly (i.e. not via the thalamus)
Projects directly to emotion (amygdala) and memory (hippocampal) centres
Describe reception at the gustatory system (5)
Tounge is main organ of taste but pharynx, palate and epiglottis also contribute
Odours and olfactory system strongly contribute to taste perception
Visual appearance
Texture
First step is break down of food by enzymes in saliva to solubilise
Taste buds are localised to which three types of papillae? (3)
Circumvallate papillae – largest, contain many thousands of taste buds, located at posterior
Foliate papillae – elongated structure, contain hundreds of taste buds, lie along posterior lateral edge
Fungiform papillae – smallest, contain one or two taste buds, widespread across anterior portion and tip of tongue
Describe taste transduction (4)
Dissolved molecules interact with receptors
Triggers membrane depolarisation & action potential firing
Accompanied by increase in intracellular calcium which initiates transmitter release
Transmitters excite afferent nerve fibres
Describe the gustatory pathway (3)
1st order neurons project to medulla
2nd order neurons project to thalamus
3rd order neurones project to gustatory cortex
What is somatosensation? (1)
Ability to sense
What is the somatosensory system? (1)
Responds to the external environment
What is the Viscerosensory system? (1)
Responds to the internal environment