Sensation And Perception Final Flashcards
Why is touch important?
- Survival: sensing danger (temperature), feedback from environment
- Social interactions: shaking hands, placing hands on back
Somatic senses
- Sensing the physical state of the body based on a variety of info
- 5 of them
Tactile sensation (somatic sense)
- Position and structure of objects making contact with body surface
Nociception (somatic sense)
- Sensing noxious stimuli applied to body
2. Ex. Pain
Temperature (somatic sense)
- Sensing stimuli that are warmer or colder than body surface
Proprioception (somatic sense)
- The sense of the position of the limbs
Kinesthesis (somatic sense)
- The sense of movement of the limbs and body
Layers of the skin
- Epidermis: outer layer (including a layer of dead skin cells) hairy and glabrous (hairless)
- Dermis: inner layer of skin
- Skin considered a single (and largest) organ
Mechanoreceptors
- Sensory receptors in the skin that respond to touch (pressure)
- Convert mechanical energy into electrochemical energy
- 4 kinds
Merkle receptors
- fires to continuous pressure
- fine detail perception
- Location: epidermis
Meissner corpuscle
- Location: epidermis
- On/off stimulation
- Tapping, grabbing perception
Ruffin cylinder
- Fires to continuous pressure
- Stretching perception
- Location: dermis
Pacinian corpuscle
- On/off stimulation
- Vibration perception
- Location: dermis
Thermoreceptors
- Sensory receptors that respond to temperature
2. Warm fiber and cold fibers
Warm fiber
- Increases its response rate as temp is increased
- Continues to fire as long as higher temp continues
- Decreases its firing rate when the temperature is decreased
- Does not respond to mechanical stimulation
Cold fiber
- Increase firing rate when temp decreased
2. Continue to fire at low temperatures
Cortical processing of touch
- Tactile information is represented in the primary somatosensory cortex (S1) and the secondary somatosensory cortex (S2)
- Location information is maintained in a spatial map
- S1 and S2 is in the parietal lobe
Spatial map in S1
- Homunculus: Latin for little man
2. Larger = higher tactile acuity, greater cortical representation
S1 neurons and receptive fields (somatosensory-style)
- Area on the skin that an S1 neuron is particularly sensitive to
- Firing rate increases when area is stimulated
- Center-surround organization
How receptive fields map onto tactile acuity
- Tactile acuity: perceiving fine details via your sense of touch
- Large RF = low resolution, less detail
- Small RF = high resolution, more detail
- Merkel cells have smallest RF = can perceive most detail
How RF size varies with location on skin
- Two-point threshold: the distance at which 2 pressure points can be distinguished
- Millimeters for fingers, centimeters for back because RF size is smaller on fingers than on back
Cortical plasticity in S1
- S1 is plastic: changes with experience
- Training/ stimulation of fingers alters the cortical representation
- In humans: pianists have larger cortical area devoted to their fingers than normal individuals
Perceiving objects via sense of touch
- Haptic exploration: exploring an object via your sense of touch
- Research shows that people can identify objects haptically in 1-2 seconds
Physiology of tactile object perception
- Features of an object are processed first
- Occurs in S1 > S1 neurons are selective > respond to particular orientations/directions
- Features then combined to make a whole object
- Occurs in S2 and higher areas > some neurons selective to specific objects
S1 and attention
- Some neurons in S1 only respond when monkey is attending to the tactile stimulus
Pain perception
- Pain is necessary: need to know whether the body is hurt or in danger of being hurt
Experience of pain
- Nociceptors: sensory receptors that respond to potentially harmful stimuli (temperature, pressure, chemical)
- These receptors send pain info to brain stem and cortex
Types of physical pain
- Nociceptive pain: nociceptor activation, results from extreme heat/cold, chemicals, extreme pressure
- Inflammatory pain: damage to tissues, joints
- Neuropathic pain: carpal tunnel, damage to nervous system from spinal cord injury or stroke, phantom limb pain
Brain areas involved in pain perception
- Pain is multimodal
- Somatosensory cortex S1 (parietal lobe)
- Thalamus
- Temporal lobe
- Amygdala
- Hypothalamus
- Prefrontal cortex
- Anterior cingulate cortex
Gate control theory of pain (modulating pain)
- Spinal cord contains neurological gate that blocks pain signals or allows them to continue to the cortex
- Factors that open/ close the gate: nociceptor activity, activity in other receptors, input from the brain
Emotional factors that open/close gate (gate control theory)
- Open gate: anxiety, worry, panic, depression
- Close gate: happiness, relaxation, excitement,
- endorphins close gate: massage, nutrition, injections, exercise, positive attitude, pacing activities, distractions from pain
Cognitive factors in modulating pain: anticipation
- Anticipation
- Pain tolerance study;
- subjects had to put hand in ice water, FMRI measured
- Results: anticipating pain produced same brain activation as experiencing the pain
Cognitive factors in modulating pain: expectations
- Expectation
2. If patient told a procedure won’t hurt, they will experience less pain (placebo effect)
Cognitive factors modulating pain: attention
- Attention
- Experience of pain might not set in until you attend to the injury
- Attending away from the injury: can withstand pain longer
- ex. Show men pictures of attractive females, they can keep their hand in ice water for longer
Hypnosis
- Hypnosis induced pain is similar to physical pain
2. Hypnosis can also reduce pain perception
Emotional and social pain
- Emotional (break ups)
- Social (exclusion from a group)
- Empathic pain (watching someone else hurt, actually activates pain network)
Phantom limb pain
- Experiencing pain/ sensation in a limb that is no longer there
- Why? Cortical representation of limb is still there
- Treated with mirror therapy
Inability to perceive pain
- Congenital (from birth) inability to perceive pain
2. Extremely dangerous condition
Olfaction
- Our sense of smell
Functions of olfaction: identifying substances
- Smell helps to identify substances
- Knowing if smell is delicious or deadly
- Detecting fire/smoke in house
- Baby needing diaper change
- Knowing if it’s time to shower
Functions of olfaction: identify sexual partners
- Smell helps to identify sexual partners
- We all have unique, genetically determined scent
- Study: males slept in t-shirt for 2 nights (no deodorant).
- Females sniffed t-shirt and rated smell for pleasantness and sexiness
- Before study: males and females tissue typed for major histocompatibility complexes (vital part of immune system)
- Results: females gave highest ratings to t-shirts worn by men whose MHCs differed most from their own
Functions of olfaction: filter and humidity
- Smell helps to filter and humidify air
- Air is warmed
- Hairs in nasal cavity remove dust/debris
Smell stimulus (2)
- Odor: smell
2. Odorant: what produces the smell
At what point can we detect smell in environment?
- Olfactory receptors activated by 1 molecule odorant
- But smell isn’t perceived until many molecules processed
- Most smells consist of many molecules (coffee = 100 molecules)
Odor detection thresholds
- Detection threshold: lowest concentration at which an odorant can be detected (measured in parts per billion ppb)
- Different threshold for different odors
- some easy/ not easy to smell (skunk vs. ants)
- Detection thresholds vary by person
Odor sensitivity is affected by?
- Odor sensitivity affected by: time of day, age, sex, time of month for females (> when ovulating), smoking
- Some people put off by odors others cannot even smell
Odor sensitivity in animals
- Rats 8-50 times more sensitive to odors
- Dogs: 300-10,000 more sensitive
- Receptors for these animals equally sensitive
- Difference is number of receptors: humans have 10 million, dogs have 1 billion
Recognizing odors
- Threshold for odor recognition not the same as threshold for odor detection
- We can only identify a small subset of the smells we experience
- Might be a memory problem rather than a sensory problem
Primary odors
- Musky: perfumes, aftershave
- Putrid: rotten eggs
- Pungent: vinegar
- Camphoraceous: moth balls
- Ethereal: dry cleaning fluid
- Florals: roses
- Peppermint: mint gum
Smelling process
- Odorant molecules reach olfactory mucosa, containing olfactory receptor neurons (ORNs)
- Odorant molecules bind to receptor proteins on the cilia of the ORNs
- Binding opens ion channels, depolarizing the cell
- Signal is sent to the olfactory bulb in the brain
- Glomeruli organize information in the olfactory bulb
- Organized signal is sent to primary olfactory cortex (piriform cortex) and then to secondary olfactory cortex (orbitofrontal cortex) where higher-level processing occurs
Olfactory mucosa
- dime-sized region on the roof of the nasal cavity
Olfactory receptor neurons (ORNs)
- Located on the mucosa, respond to odor stimuli and transduce signal
- Humans have 10 million ORNs of 350 different types
Neurogenisis
- ORNs replaced every 5-7 weeks
- New neurons must: 1. Grow axons that travel from mucosa to olfactory bulb (3-4cm)
- Duplicate connections made by predecessor cells
Receptor proteins on ORNs
- We have 1000 receptor proteins, each sensitive to different odorants
Olfactory bulb
- Brain structure where olfactory signals are collected from the
ORNs
Glomeruli
- Groups of cells in olfactory bulb that receive input from similar ORNs
- Receive input from 5,000-10,000 ORNs
- Help organize and categorize by smell
- Has a odotopic map
Important odor notes (3)
- Odor information goes directly to the brain (no intervening synapses)
- Odor information is organized in the brain (like visual, auditory, and touch)
- We have many more types of receptors for smell than for our other senses, yet we rely on it the least.
Organization of smell
- Odors occur concurrently (simultaneously)
2. Perceptual system separates them
Top down influences on odor perception
- Past experience: quickly identify a familiar smell
- Expectations: general understanding for how things smell
- Knowledge/descriptive info: smell reported more pleasant when told it was cheddar cheese than when told it was body odor
- pleasantness ratings associated w/higher orbitofrontal activation
Anosmia
- Odor blindness
- Causes: congenital, blockage/inflammation of nasal pathway, damaged olfactory receptors, damaged olfactory nerve, damaged piriform cortex, old age, smoking/snorting things, drugs
- Can be in only 1 nostril (if damage is unilateral)
- Can be specific to certain smells (sweet, musky, etc.)
Consequences of losing sense of smell
- Eating is less pleasant
- Loss of appetite and weight
- Dull sex drive
Phantosmia
- Hallucinations of smell
- Often unpleasant
- Can be caused by migraines, Parkinson’s, mood disorders, damage to piriform cortex, schizophrenia
Why is taste important?
- Security system: sensing when something is poisonous
- Homeostasis: getting nutrients, cravings tell us what we need
- Pleasure purposes: eating feels good
Taste
- ability to respond to soluble substances (things that dissolve on our tongue
Tastant (5 of them, what are they?)
- Taste stimulus (various categories)
- Sour: potentially spoiled
- Sweet: nutritional value
- Bitter: potentially toxic
- Salty: regulating bodily fluids
- Umami: savory/meaty flavored
Tongue
- Receptor surface for taste
Papillae
- Bumps on the tongue
Filliform
- Cone-shaped
- Located along entire tongue
- Does not contain taste buds
Fungiform
- Mushroom shaped
- Located along tips and sides
- Contains taste buds
Foliate
- Folds, located on sides
2. Contain taste buds
Circumvallate
- Mound shaped
- Located at back
- Contains taste buds
Taste buds
- Has 10,000 taste buds
- Located on papillae
- Clustered on edges and back of tongue (not many in the middle)
- Short life span…only 10 days
- Each taste contains 50-100 taste receptor cells
- Micovilli protrude into the taste pore
- This is where tastant info is received
Taste cells
- One taste cell contains various receptor sites for the different flavors
- At receptor sites is where transduction begins
Taste transduction
- Salty: Na+ influx
- Sour: reduction of K+ outflow
- Sweet: elicits signal via enzyme cascade
- Bitter: blocks signal via enzyme cascade
Taste Transduction simplified
- Mouth
- Tongue
- Papillae
- Taste buds
- Taste cells
- Receptor sites
Neural code of taste
- All taste cells contain receptor sites for all 4 tastes
- But certain taste cells might respond more to one type than another
- Seems like taste receptors have a preference
3 pathways to brain through cranial nerves (CN)
- Glossopharangeal nerve: back of the tongue
- Chords tympani nerve: front/sides of tongue
- Vagus nerve: mouth and larynx, can taste without tongue
Taste process in the brain
- CNs synapse in the nucleus of the solitary tract in brain stem
- Thalamus
- Primary taste cortex: insula, frontal operculum
- Secondary taste cortex: orbitofrontal cortex
Insula
- Folded deep in the brain
- Signals disgustingness or unpleasantness
- Primary taste cortex
Frontal operculum
- Cortical region that folds over the insula
2. Primary taste cortex
Secondary taste cortex
- Orbitofrontal cortex
Interaction between taste and smell
- Smell and taste are processed in same secondary area of the cortex
- Orbitofrontal cortex: gathers info from all the senses
- Contains bimodal neurons: neurons that respond to 2 senses
- smell and taste
- audition and vision
Flavor perception in orbitofrontal cortex
- Flavor = smell and taste components activated in OFC via bimodal neurons
- Either smell or taste will activate this area, and in turn will activate the other
3.
Hunger and OFC
- Study in monkeys
- When monkey hungry: increased firing rate and licking rate of cream intake
- As monkey satiated: decrease firing rate and licking rate
Bottom up and top down process of taste
- Physical properties of food: smell, temperature, texture, consistency
- Color
- Genetics: genetic aversions to food (cilantro)
- Prenatal nutrition: mom ate spicy food when pregnant, you probably like it
- Physiological: salt content in saliva, cravings
- State of olfaction: whether or not you can smell
- Experience: food you ate as a child, conditioned taste aversion (food sickness)
- Expectation: we know what it taste like
- Anticipation: salivation occurring before you taste
- Emotional state: sad, happy, depressed, anxious
- Adaptation: as you eat, you adapt to flavor, may make you bored
Supertasters
- More sensitive to flavors (mostly bitterness)
- More taste buds than non tasters
- Picky eaters
- Super tasters 25% pop
- Medium tasters 50% pop
- Non tasters 25% pop
Threshold for taste
- Extremely difficult to measure
- Super tasters and non-tasters have different threshold ceilings
- No threshold of the Texan is the same for everyone
Disorders of taste: Ageusia
- inability to taste
- Very uncommon
- All 3 pathways impaired
- Causes: radiation therapy, head trauma, congenital
Disorders of taste: Dysgeusia
- Tasting without stimulation, distorted taste
- Results in experiencing taste as salty, metallic or bitter
- Causes: drugs, damage to taste nerves
Disorders of taste: Hypogeusia
- Decreased taste
- Result in decreased food intake, weight loss
- Causes: aging, impaired olfaction (a cold)