senescence Flashcards

1
Q

lors de senscence:
+ augmentation de ….
+ surexpression de ….
+ Modification de chromatine: formation de ….. ,methylation de H3
+ Secretome= ……. : cytokines, protease ..

A

+ augmentation de p53 et p21
+ surexpression de B-GALACTOSIDASE
+ Modification de chromatine: formation de SAHFs (senescence associated heterochromatin foci),methylation de H3
+ Secretome= SASP (Secenscence-associted secretory phenotype) : cytokines, protease ..

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2
Q

………. (genetique) => genes permet de resister au senescence

A

gerontogenes

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3
Q

Reservertol => agit sur …….. => compactage de chromosome + stimule la detoxification + active …..

A

Reservertol => agit sur sirtuines 1 => compactage de chromosome + stimule la detoxification + active p53 +

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