SEMANA 2 TTO Flashcards

1
Q

Medicamentos no biologicos

A

Metotrexato
Hidroxicloroquina
Sulfasalazina
Leflunomida
Tofacitinib

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2
Q

Medicamentos Biologicos

A

Anti TNF
Anti IL-6
Anti IL1
Anti IL17
Anti CD20

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3
Q

Metotrexato

A
  • Antimetabolito
  • Inhibe la dihidrofolato reductasa lo que baja el folato intracelular y así no se sintetiza nuevos ácidos nucleicos
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4
Q

Hidroxicloroquina

A
  • Antiproliferativo
  • Disminuye citoquinas
  • Disminuye qumitoxis
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5
Q

Sulfazalazina

A

Inmunosupresivo
Antibacterial
Antiinflmatorio

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6
Q

Leflunomida

A
  • Inhibidor de la enzima dihidroorato deshidrogenasa
  • no pirimidina
  • no adn
  • no linfocitos
    – se puede usar en pacientes que no toleran el mtx
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7
Q

ANTI TNF

A

Etanercept
Infliximab
Adalimumab
Certolizumab pegol

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8
Q

Certolizumab pegol ( anti TNF)

A
  • se puede usar sin mtx
  • en embarazadas y edad fertil como tambien la azatioprina y la Hidroxicloroquina
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9
Q

ANti IL-6 ( tocilizumab)

A

cuando no se tolera el mtx
- I.Hepatica
- I. Renal

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10
Q

Anti IL 1

A

Anakinra

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11
Q

ANti IL- 17

A

Secukinumab
- cuando no hay como dar antiTNF
- tuerculosis
NO hay en ECU

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12
Q

Anti CD20

A

Rituximab
- en Cancer linfoproliferativo, tuberculosis

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