sem B - drug treatment of depression

Question 1

what was the 1st antidepressant drug

Answer 1

iproniazid

Question 2

how was the first antidepressant drug discovered

Answer 2

new treatment for TB but cured depression - by blocking enzyme monoamine oxidase so monamines are not broken down

Question 3

what is the monoamine hypothesis of depression

Answer 3

reduced levels of monoamine in brain causes depression (reduced noradrenaline, dopamine, serotonin)

Question 4

MAO neurotransmission

Answer 4

-MAO neurotransmitter is packaged into vesicles and released into synaptic cleft by exocytosis
-NT activates post-synaptic MAO receptors
-MAO transporter reuptakes NT into presynaptic NT
-NT is either repackaged into vesicles or broken down by MAO into inactive metabolites

Question 5

MAO inhibitors - blocks breakdown of

Answer 5

monoamines

Question 6

tricyclic antidepressants block …… preventing reuptake into presynaptic neurone, so it builds up in synaptic cleft. are selective/non-selective

Answer 6

MA reuptake transporter
-selective

Question 7

SNRIs - selective to …. and …. blocking their reuptake

Answer 7

noradrenaline and serotonin

Question 8

SSRIs - selective to ….. blocking their reuptake

Answer 8

serotonin

Question 9

NRIs - selective to …. blocking their reuptake

Answer 9

noradrenaline