Selective Sodium Glucose Cotransporter 2 Inhibitors (SGLT2)

Question 1

SGLT-2s “-flozins” (Invokana, Jardiance, Farxiga) MOA

Answer 1

• inhibits SGLT2 enzyme in the kidney, blocking the reabsorption of glucose in the kidneys - increased secretion of sugar in the urine - works like a diuretic
  Does not cause hypoglycemia - weight negative (H2O loss)

Question 2

SGLT-2s ADRs

Answer 2

• UTI
• genital fungal infections
• hypotension / dehydration
• hyperkalemia
• bladder CA

Question 3

SGLT2s “-flozins” contraindications

Answer 3

• severe renal impairment

Question 4

SGLT2s counseling points

Answer 4

• black box (potential) - BKA, bladder CA, Fournier gangrene