Selection Flashcards
1
Q
Thymic nurse cells
A
multicellular complexes of cTECs that can encompass up to 20 developing thymocytes
Decreased in TCR transgenic mice (enhanced beta selection)
Associated with more alpha rearrangements
2
Q
Lifespan of DP’s prior to death by neglect
A
DPs mus engage peptide MHC on cTecs within 3-4 days or they undergo death by neglect.
3
Q
B5t
A
Unique subunit of Proteosome expressed in ctecs
the proteosomes that incorporate it are called “Thymoproteosomes”
4
Q
Consequences Thymoproteosome deficiency
A
in mice: defective +ve selection of CD8 t cells.
5
Q
Consequences of TSSP-Deficiency
A
Thymus specific serine protease that is expressed in cTECs
Normal polyclonal CD4 T cells
Defective selection of some Class II restricted TCRs
altered antigen specific CD4 T cell responses
