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HEMATOLOGY > Selected Cytokines, Characteristics, and Current and Potential Therapeutic Applications > Flashcards

Selected Cytokines, Characteristics, and Current and Potential Therapeutic Applications Flashcards

1
Q

Primary cell source of EPO

A

Kidney (peritubular interstitial cell)

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2
Q

Primary target cell of EPO

A

Bone marrow erythroid progenitors (BFU-E and CFU-E)

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3
Q

Biologic activity of EPO

A

Simulates proliferation of erythroid progenitors and prevents apoptosis of CFU-E

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4
Q

Current/Potential therapy application of EPO

A

Anemia of chronic renal disease (in predialysis, dialysis dependent, and chronic anemia patients)
Treatment of anemia in cancer patients on chemotherapy
Autologous predonation blood collection
Anemia in HIV infection to permit use of zidovudine (AZT)
Post autologous hematopoietic stem cell transplant

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5
Q

Primary cell source of G-CSF

A

Endothelial cells
Placenta
Monocytes
Macrophages

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6
Q

Primary target cell of G-CSF

A

Neutrophil precursors
Fibroblasts
Leukemic myeloblasts

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7
Q

Biologic activity of G-CSF

A

Stimulates granulocyte colonies
Differentiation of progenitors toward neutrophil lineage
Stimulation of neutrophil maturation

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8
Q

Current/Potential therapy application of G-CSF

A

Chemotherapy-induced neutropenia
Stem cell mobilization
Peripheral blood/bone marrow transplantation
Congenital neutropenia
Idiopathic neutropenia
Cyclic neutropenia

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9
Q

Primary cell source of GM-CSF

A

T cells
Macrophages
Endothelial cells
Fibroblasts
Mast cells

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10
Q

Primary target cell of GM-CSF

A

Bone marrow progenitor cells
Dendritic cells
Macrophages
NKT cells

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11
Q

Biologic activity of GM-CSF

A

Promotes antigen presentation
T cell homeostasis
Hematopoietic cell growth factor

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12
Q

Current/Potential therapy application of GM-CSF

A

Chemotherapy-induced neutropenia
Stem cell mobilization
Peripheral blood/bone marrow transplantation
Leukemia treatment

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13
Q

Primary cell source of IL-2

A

CD4+ T cells
NK cells
B cells

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14
Q

Primary target cell of IL-2

A

T cells
NK cells
B cells
Monocytes

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15
Q

Biologic activity of IL-2

A

Cell growth/activation of CD4+ and CD8+ T cells
Suppress T-reg responses
Mediator of immune tolerance

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16
Q

Current/Potential therapy application of IL-2

A

Metastatic melanoma
Renal cell carcinoma
Non-Hodgkin lymphoma
Asthma

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17
Q

Primary cell source of IL-3

A

Activated T cells
NK cells

18
Q

Primary target cell of IL-3

A

Hematopoietic stem cells and progenitors

19
Q

Biologic activity of IL-3

A

Proliferation of hematopoietic progenitors

20
Q

Current/Potential therapy application of IL-3

A

Stem cell mobilization
Postchemotherapy/transplantation
Bone marrow failure states

21
Q

Primary cell source of IL-6

A

T cells
Macrophages
Fibroblasts

22
Q

Primary target cell of IL-6

A

T cells
B cells
Liver

23
Q

Biologic activity of IL-6

A

Costimulation with other cytokines
Cell growth/activation of T cells and B cells
Megakaryocyte maturation
Neural differentiation
Acute phase reactant

24
Q

Current/Potential therapy application of IL-6

A

Stimulation of platelet production, but not at tolerable doses
Melanoma
Renal cell carcinoma
IL-6 inhibitors may be promising

25
Q

Primary cell source of IL-10

A

CD4+, Th2 T cells
CD8+ T cells
Monocytes
Macrophages

26
Q

Primary target cell of IL-10

A

T cells
Macrophages

27
Q

Biologic activity of IL-10

A

Inhibits cytokine production
Inhibits macrophages

28
Q

Current/Potential therapy application of IL-10

A

Target lymphokines in prevention of B cell lymphoma and Epstein-Barr virus lymphomagenesis
HIV infection

29
Q

Primary cell source of IL-12

A

Macrophages

30
Q

Primary target cell of IL-12

31
Q

Biologic activity of IL-12

A

T cell, Th1 differentiation

32
Q

Current/Potential therapy application of IL-12

A

Allergy treatment
Adjuvant for infectious disease therapy
Asthma
Possible role for use in vaccines

33
Q

Primary cell source of IL-15

A

Activated CD4+
T cells

34
Q

Primary target cell of IL-15

A

CD4+ T cells
CD8+ T cells
NK cells

35
Q

Biologic activity of IL-15

A

CD4+/CD8+ T cell proliferation
CD8+/NK cell cytotoxicity

36
Q

Current/Potential therapy application of IL-15

A

Melanoma
Rheumatoid arthritis
Adoptive cell therapy
Generation of antigen-specific T cells

37
Q

Primary cell source of IFN-a

A

Dendritic cells
NK cells
T cells
B cells
Macrophages
Fibroblasts
Endothelial cells
Osteoblasts

38
Q

Primary target cell of IFN-a

A

Macrophages
NK cells

39
Q

Biologic activity of IFN-a

A

Antiviral
Enhances MHC expression

40
Q

Current/Potential therapy application of IFN-a

A

Adjuvant treatment for stage II/III melanoma
Hematologic malignancies: Kaposi sarcoma, hairy cell leukemia, and chronic myelogenous leukemia

HEMATOLOGY (4 decks)

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