Seizures Oral Dosage Stuff

Question 0

Valproate dosing for absence seizures

Answer 0

Troph levels 50-100 mg/L

Can go up to 200mg/L

Question 1

Valproate (depakote) indications

Answer 1

MONOTHERAPY for simple and complex seizures
MONOTHERAPY for complex
So basically it’s super broad

Question 2

Valproate dosing for regular

Answer 2

10-15 mg/kg/day
Increase by 5-10 mg/kg weekly
Max is 60mg/kg

Question 3

Valproate acid adverse effects

Answer 3

Cns (sedation nausea dizziness tiredness headache, etc)
Tremors (careful with Parkinson’s patients)
Hyper ammonia (lethargy, vomiting
GI
Weight gain
Pancreatitis
Polycyclic ovarian syndrome
Rash
Hair thinning
Thrombocytopenia but usually benign and inhibits platelet aggregation

Question 4

Monitoring for valporic acid

Answer 4

Lfts lets
Ammonia levels
Rash

Question 5

Biggest risk for hepatotoxicity with depakote

Answer 5

Children under 2 and mental retardation.

Question 6

Cosmetic changes and trx with valproic acid

Answer 6

Weight gain and alopecoa and change in texture (is transient)

Trx for hair is zinc or selenium

Question 7

Depakene

Answer 7

Valproic acid capsules gi disturbances big time <tid or qid

Question 8

Depakote

Answer 8

EC
BID (delayed absooption)