Seizures Flashcards
What is a seizure?
A single, self-limiting occurrence of ‘jerky’ movements.
Seizures can vary in duration and intensity.
What defines epilepsy?
Two or more unprovoked and continuous/contiguous seizures.
Epilepsy often requires long-term management.
Does a seizure require treatment with anti-epileptic medications or surgery?
No- it requires monitoring for safety.
Seizures may resolve on their own without intervention.
Are anti-epileptic medications necessary for epilepsy?
Yes, they are necessary and life-saving measures are required.
(its in the name)
Surgery may be an option in certain cases.
What type of seizure is limited to one hemisphere of the brain?
Focal seizure
Focal seizures are limited to one hemisphere of the brain.
What type of seizure occurs and engages bilaterally?
Generalized seizure
Generalized seizures involve both hemispheres of the brain.
What is the classification of seizures that involves epilepsy spasms?
Unknown seizures
Unknown seizures are characterized by epilepsy spasms and lack sufficient data for classification.
Fill in the blank: Seizures that are related to an acute, reversible condition are classified as _______.
Provoked or acquired
Provoked seizures occur as the result of trauma, low blood sugar (hypoglycemia), low blood sodium, high fever, or alcohol or drug abuse.
Specific causes of “Acquired” Seizures
- Cerebrovascular disease
- Hypoxia – poor tissue O2, Hypoxemia – low SaO2
- Eclampsia
- Fever (childhood) – “convulsion”
- Head injury / TBI – up to 5 of 10 w/ TBI
- Hypertension – 2.5 fold increase risk in elderly
- Central nervous system infections
- Metabolic and toxic conditions – (hyponatremia)
- Brain tumor – frontal, parietal, temporal
- Drug and alcohol withdrawal
- Allergies – kids w/ allergic rhinitis = 76% higher risk
What condition can cause seizures during pregnancy?
Eclampsia
Eclampsia is a severe complication of pregnancy characterized by seizures.
Q: How does eclampsia cause seizures?
A: Eclampsia is a pregnancy complication involving severe hypertension, proteinuria, and seizures due to brain edema and ischemia.
Q: Why do childhood fevers sometimes cause seizures?
A: High fevers in young children can trigger febrile seizures, also known as convulsions, due to increased neuronal excitability.
Q: What is the relationship between head injury (TBI) and seizures?
Traumatic brain injuries (TBI) can cause seizures, with up to 50% of patients developing post-traumatic epilepsy.
This statistic highlights the significant risk associated with TBI.
Q: How can central nervous system (CNS) infections lead to seizures?
A: Infections like meningitis, encephalitis, and brain abscesses cause inflammation, fever, and direct brain damage, triggering seizures.
Infections like meningitis or encephalitis can trigger seizures.
Q: What metabolic and toxic conditions can cause seizures?
A: Electrolyte imbalances, such as hyponatremia, along with renal failure, hepatic encephalopathy, and toxin exposure, can provoke seizures.
Low sodium levels can lead to seizures among other symptoms.
Which brain tumors are commonly associated with seizures?
Frontal, parietal, temporal
These regions of the brain are often implicated in seizure activity.
Q: Why can drug and alcohol withdrawal cause seizures?
A: Abrupt cessation of alcohol, benzodiazepines, or other depressants can cause hyperexcitability in the brain, leading to withdrawal seizures.
Withdrawal from substances can trigger seizures in some individuals.
Q: How do allergies increase seizure risk in children?
A: Children with allergic rhinitis have a 76% higher risk of seizures due to inflammatory and immune system effects on the brain.
Allergies can be a contributing factor to seizure risk in children.
What can cause Seizures in Newbornn and Infants
- Severe hypoxia
- Genetic metabolic defects
- Congenital defects involving the CNS
- Alcohol or barbiturate withdrawal
- Birth trauma
- Infections
- Metabolic disorders: hypoglycemia, hypocalcemia, vitamin B6 deficiency
What characterizes generalized seizures?
Involves both hemispheres, often causing loss of consciousness (seconds to minutes)
Generalized seizures affect both sides of the brain simultaneously.
What are the 2 main types of generalized seizures?
- Motor (tonic-clonic)
- Absence seizures
These classifications help in understanding the different manifestations of seizures.
What are 5 symptoms of motor (tonic-clonic) seizures?
- Muscle stiffness
- Rhythmic jerking
- May result in loss of consciousness
- Falls
- Vocalization
Tonic-clonic seizures can involve both phases: tonic (stiffening) and clonic (jerking).
What are absence seizures characterized by?
Brief <15 seconds but can lasts up to 30 secs.
Episodes of brief disturbance of brain function
Absence seizures are also known as petit mal seizures.
What are common symptoms of absence seizures?
- Blank stare - lasting 15-30 secs
- Sudden stop in activity
- Lip smacking
- Eyelid fluttering
- Small hand movements
No memory of the event
These symptoms can occur without the individual being aware of the seizure.
True or False: Individuals remember absence seizures after they occur.
False
There is typically no memory of the event associated with absence seizures.
Seizures occur in distinct phases.
Name these 4 phases?
- Prodromal phase
- Aural phase “Pre-ictal”
- Ictal phase
- Postictal phase
What is the prodromal phase of seizures?
Signs or activity that precede a seizure
The prodromal phase may include changes in mood, behavior, or physical sensations.
What occurs during the aural phase of a seizure?
Sensory warning in some patients
This phase is also referred to as the ‘pre-ictal’ phase and may involve visual or auditory sensations.
What is the ictal phase?
Full seizure activity
This phase is characterized by the actual seizure, which can vary in duration and severity.
What is the postictal phase?
Recovery period after seizure
This phase can involve confusion, fatigue, and other neurological symptoms as the brain recovers.
Q: What is an aura in relation to seizures?
A: An aura is a sensory warning that occurs BEFORE a seizure, signaling abnormal brain activity.
What are 5 common symptoms of a seizure aura?
- Nausea or abdominal discomfort
- Faintness or dizziness
- Headache
- Aphasia
- Numbness of hands, lips, or tongue
- Choking or throat sensation
- Unpleasant taste or smell
- Dread
- Dream state
A seizure aura is a warning sign that some people experience before a seizure occurs, often involving sensory or emotional changes.
True or False: Headache is a symptom of a seizure aura.
True
What does aphasia refer to in the context of seizure auras?
Aphasia refers to difficulty with language or communication.
Fill in the blank: A seizure aura may cause _______ of hands, lips, or tongue.
Numbness
How long do Aura’s last?
seconds to 60 minutes
(BEFORE a seizure)
What is the primary aim of medication therapy for seizures?
Aimed at prevention; cure not possible
Medication therapy focuses on preventing further seizures rather than curing the underlying condition.
What is the mechanism by which seizure medications work?
Stabilize nerve cell membranes and prevent spread of epileptic discharge that causes sizure symptoms.
This mechanism helps to control seizures by reducing excessive electrical activity in the brain.
What percentage of patients achieve seizure control with medication?
70%
This statistic indicates the effectiveness of medication in managing seizures for a majority of patients.
What is the therapeutic range for Phenobarbital?
15-40 mcg/ml
How long can it take for Phenobarbital to reach peak levels in the brain?
Up to 15 minutes
What is the maximum rate of administration for Phenobarbital?
60 mg/min
True or False: Too rapid administration of Phenobarbital can cause serious respiratory depression.
True
What is a risk of withdrawing (stoping abruptly) Phenobarbital too quickly?
Can trigger status epilepticus
is a medical emergency where a seizure lasts longer than 5 minutes or multiple seizures occur without the person regaining consciousness in between.
What should be monitored closely when administering Phenobarbital?
- Patient
- Ensure patent airway
Why should extravasation of the vein be avoided with Phenobarbital?
Its very alkaline, making it harsh on tissues causing inflammation, necrosis (tissue death), and severe pain at the injection site.
How to prevent extravasation?
- Use a large, patent vein for IV administration.
- Monitor the IV site closely for redness, swelling, or pain.
- Administer slowly to reduce irritation.
- Flush with normal saline before and after administration.
What is the only solution compatible with Phenobarbital?
0.9% NS
What are the 3 primary drugs used to treat generalized tonic-clonic and partial seizures?
- Phenytoin (Dilantin)
- Carbamazepine (Tegretol),
- Divalproex (Depakote).
What is a characteristic of OLDER seizure medications?
Require constant monitoring
Older medications can have more side effects and interactions.
Q: What are 3 key considerations for phenytoin (Dilantin)?
- Many side effects
- take with meals
- Drug interactions with birth control pills (BCP) and alcohol (ETOH).
What are some side effects of phenytoin (Dilantin)?
- Fatigue is normal
- sedation indicates toxicity (check levels).
- many drug interactions
Patients are advised to take it with meals.
What is an important dietary consideration for patients taking carbamazepine (Tegretol)?
Avoid grapefruit
Grapefruit can increase medication levels in the body.
What are 3 common side effects of carbamazepine (Tegretol)?
Constipation, dry mouth, drowsiness
These side effects can affect patient compliance.
What are the potential side effects of divalproex (Depakote)?
- Agitation
- irritability
- depression
- suicidal thoughts
Monitoring for these effects is crucial for patient safety.
What organ be monitored in patients taking divalproex (Depakote)?
Hepatic toxicity
Liver function tests should be performed periodically.
True or False: Fatigue is a normal side effect of phenytoin (Dilantin).
True
While fatigue is expected, sedation may indicate toxicity.
What are the 3 effective medications for absence, akinetic, and myoclonic seizures?
- Ethosuximide (Zarontin)
- Divalproex (Depakote)
- Clonazepam (Klonopin).
What are the side effects of Divalproex (Depakote)?
- N/V
- somnolence
- weight gain
- hepatic toxicity
- GI upset/ulcers if pills are crushed.
Divalproex is used for various seizure types.