Seizure Disorders Flashcards
Seizures include what types of abnormal activity? (4)
- Motor
- Sensory
- Autonomic
- Psychic
Describe the physiological process that provokes seizures
Sudden, uncontrolled electrical discharge from cerebral neurons
What acute problems are associated with provoking seizures? (3)
- Hypoglycemia
- Drug / alcohol withdrawal
- Traumatic brain injury
How are seizures classified?
According to the part of the brain involved
Where do focal (partial) seizures occur?
One hemisphere
Where do generalized seizures occur?
Both hemispheres
An unknown classified seizure is due to ______
Epilepsy spasm
A provoked seizure is due to ______
Acute reversible condition
What is the requirement for a seizure to be considered epileptic?
Must be more than one unprovoked seizure - an isolated single seizure does NOT constitute epilepsy
What factors are manifestations of seizures dependent on? (3)
- The area of the brain affected
- The number of neurons excited
- The extent to which activity spreads
Sensory seizure symptoms arise from the ______
Parietal lobe
Motor seizure symptoms arise from the ______
Frontal lobe
Psychomotor seizure symptoms arise from the ______
Temporal lobe
Which gene is responsible for myoclonic epilepsy?
Chromosome 21
1/3 of seizures are ______
Secondary
2/3 of seizures are ______
Idiopathic
What are the causes of seizures? (8)
- Allergies
- Brain tumor
- CNS infections
- CVD
- Fever (childhood)
- Hypertension
- Hypoxemia
- Metabolic conditions
Seizures result in increased ______
Oxygen demand
What pathological factor is most likely responsible for seizures?
Insufficient amounts of GABA (inhibitory neurotransmitter)
What occurs if the body regains homeostasis after a seizure?
No residual damage
Everyone has a ______
Seizure threshold - when exceeded, a seizure may result
What is an epileptogenic focus?
Neurons that initiate a seizure
During a seizure, ______ increase dramatically
Metabolic needs of the brain
What metabolic needs of the brain increase during a seizure? (2)
- Cerebral blood flow
- Glucose and oxygen - needed for ATP
The period prior to a seizure that warns the patient of an impending seizure is called ______
Aura
What is an aura?
An intense taste / odor / sensory hallucination (ex. feeling of spiders crawling on the skin)
The seizure itself is called ______
Ictus
The period following a seizure is called ______
Postictal
What are the types of focal seizures? (2)
- Simple partial seizures
- Complex partial seizures
Partial seizures are ______, meaning they arise from a localized area of the brain
Jacksonian
Describe the characteristics of simple partial seizures (4)
- Consciousness is not affected
- No aura present
- Jacksonian March may occur
- Tremor-like movements start on one side of the body
What is Jacksonian March?
Muscle contraction that spreads centrally involving an entire limb
How long do simple partial seizures last?
30 - 60 seconds
A simple partial seizure may progress to a ______
Tonic-clonic seizure
What are the manifestations of simple partial seizures? (7)
- Tachycardia / tachypnea
- Numbness / tingling
- Visual distortions
- ‘Deja Vu’
- Pallor
- Sweating
- Flushing
Where do complex partial seizures usually originate?
Temporal lobe
Describe the characteristics of complex partial seizures (5)
- Consciousness affected
- Aura present
- Automatisms may occur
- May remain motionless
- Unawareness of what is happening
Describe some examples of automatisms (3)
- Aimless walking
- Picking at clothes
- Lip smacking
Automatisms are ______
Involuntary
What are the manifestations of complex partial seizures? (3)
- Epigastric pain
- Tongue fasciculations
- Excessive emotions - fear, anger, irritability
What are the types of generalized seizures? (6)
- Absence (petit mal)
- Myoclonic
- Clonic
- Tonic
- Tonic-clonic (grand mal)
- Atonic
Describe the characteristics of generalized seizures (3)
- Causes reaction in both sides of the body
- Consciousness always impaired
- The patient may be hard to arouse for hours after
Describe the characteristics of absence seizures (4)
- Sudden cessation of all motor activity
- Blank, unresponsive stare
- Eyelid fluttering
- Automatisms
How long do absence seizures last?
5 - 10 seconds