Seizure Disorders

Question 1

seizures

Answer 1

paroxysmal (sudden) and excessive exitation and sychronation of population of cortical neurons in the brain that cause a variety of clinical manifestations

Question 2

epilepsy

Answer 2

a disease characterized by spontaneous recurrent seizures (several types)

Question 3

epileptogenesis

Answer 3

sequence of events that coverts a normal neuronal network into an eplieptic network

Question 4

epilepsy epidemiology

Answer 4

• lifetime prevelance of** 1-3%**
• up to **5-10% **of population will suffer a seizure
• the* thrid most common neruological disorder*
• localized (focal or partial seizure)
• spread to cause a secondary generalized sezure
• may affect all cortical neurons simultaneouslu (primary generalized seuzure)
• highest frequnce of newly identified cases occur among children < 5 years (50-100 cases/100,000) and** adults > 65 years of age** (70-50 cases/100,000)

Question 5

epilepsy physiology

Answer 5

• charaterized by **abnormal neuronal exictability **
• random firing cells
• small groups of abnormal neurons undergo prolonged depolarizatiosn associated with rapid firing (repeated AP)
• leads to abnormal synchronization
• altered neuronal microenviroment
• imbalance between* exictatory (go) signals and inhibitory (stop)*