Sedation + Behavior Guidance + Abuse/Neglect + Pain Management Flashcards
Goals of procedural sedation
- Promote patient welfare + safety
- Facilitate provision of quality care
- Minimize extremes of disruptive behavior
- Promote positive psychological response to tx
Child has ~__ alveoli at birth which grows to ~__ by adulthood
Child has ~20 million alveoli at birth which grows to ~300 million by adulthood
Respiratory system is the last to develop
Young children have less surface area for gas exchange
Hypercarbia + children
Children tolerate greater incidences of hypercarbia, unlike adults, where hypercarbia drives immediate increased respiratory response.
Hypercarbia may be associated w/ onset of cardiac arrhythmias
Pediatric diaphragms
Pediatric diaphragm is less capable of displacing large volumes in vertical dimensions.
Children have relatively small functional reserve capacity.
Likewise, children have relatively larger post-expiration volume.
Pediatric vs. adult airways
- ⇡airway resistance
- Glottis (vocal cords) are positioned more anteriorly + cephalad
- Narrowest portion of the upper airway is at level of cricoid cartilage (below vocal cords)
- A relatively larger tongue + epiglottis
- A larger head to body size ratio
- Mandible is less developed
- Potential for significant lymphoid tissue obstructing:
- Nasopharynx
- Oropharynx
- Larygopharynx
What affects medication regimen selection in sedation?
- Extent of tx
- Child temperament
- Age/parental expectations
Patient selection for sedation
- Traditional techniques have been unsuccessful in managing behavior
- Patient ASA I or ha a medical condition that is well-controlled ASA II
- Patient is pre- or uncooperative
- Extent of tx: ultimately determined by amount of LA allowed by weight
- Needle phobic; excessively fearful older child
- Older child w/ poor experiences or coping abilities
- Distance traveled even for patients w/o behavioral problems
Prematurity + sedation
- Reduced surfactant; alveoli less patent
- Less surface area for qualitative gas exchange
- Poor qualitative + quantitative gas exchange
- ⇡incidence of early life intubation
- Altered neural reflex pathways; ⇡gag reflex
- Potentially at greater risk for laryngospasm
- Hospitalization; ventilator use
Atopic triad
- Asthma
- Eczema
- Food allergy
May suggest IgE hyper-responder caution
C-spine precautions w/ sedation
Down syndrome
Arnold-Chiari malformation
ASA pre-procedure fasting guidelines for sedation
- No solid foods, non-human milk, and infant formula up to 8hr
- Clear liquids = 2hr minimum fasting period
- For children +6mo
- Clear liquids include anything w/o pulp/particulate
- Breast milk = 4hr minimum fasting period
- Infant formula = 6hr minimum fasting period
- Non-human milk = 6hr minimum fasting period
- Light meal = 6hr minimum fasting period
ADD/ADHD medications + sedation
- Should be taken following NPO guidelines
- Bladder empty prior to giving meds
- Baseline vital signs
LA toxicity
Initial signs of mild LA toxicity may mimic effects of N2O/O2 or may be misinterpreted as painful response/maladaptive behavior
- Lidocaine: CNS + CV effects
- 4.4mg/kg w/ or w/o epi
- Septocaine: CNS + CV + immune effects
- 4-5mg/kg (7mg/kg listed by manufacturer but also noted that should not be used on children <4yo; 5mg/kg noted for children)
Causes + effects of LA toxicity
- Causes of OD
- Intravascular injection
- Excess dosage delivered to patient
- Effects
- CNS excitement followed by depression, seizures, disorientation, loss of consciousness
- CV system depressed
- ⇣myocardial contractility
- ⇣cardiac output
- CV collapse
Minimal level of sedation: Cognitive Function, Physiological Function, Monitor, Personnel
- Cognitive Function: May be impaired
- Physiological Function: Not affected
- Monitor: Observation only; intermittent
- Personnel: Not specified
Moderate level of sedation: Cognitive Function, Physiological Function, Monitor, Personnel
- Cognitive Function:
- Depression
- Responds to light tactile stimulation
- Physiological Function:
- Patent, self-correcting airway
- Ventilation + CV function is adequate
- Monitor:
- O2 sat
- HR
- Intermittent BP + RR (no designated period of recording)
- Capnography recommended if patient is not capable of appropriate bi-directional verbal interactions
- EKG + defib available (should)
- Personnel:
- Person responsible for monitoring other than operator
- May do other tasks
Deep level of sedation: Cognitive Function, Physiological Function, Monitor, Personnel
- Cognitive Function:
- Depression
- Not easily aroused
- Physiological Function:
- Potential loss of airway reflexes
- CV may be affected
- Monitor:
- O2 sat
- HR
- EKG
- Capnography recommended
- Intermittent BP + RR (recorded q5min)
- Personnel:
- Person responsible solely for monitoring
Sedation - fatal trio
- Hypovolemia = Patients are NPO, verify “not over NPO” but as close to guidelines as possible
- Hypoxia = Recognize respiratory obstruction/distress immediately
- Hypercapnia = If hypoxia persists, hypercapnia may result + make patient more prone to cardiac arrhythmias
How often do you calibrate inhalation equipment (sedation)
Annually
Where do you do submucosal injection
B/w 1st and 2nd primary molar in maxillary vestibule
N2O-O2 induction + recovery
- Induction = 5min
- Recovery = 10min
Relative contraindications for N2O-O2 (may be used following med consult)
- Wheezing (moderate-severe asthma)
- Nasopharyngeal obstruction
- Tuberculosis, cystic fibrosis
- Sickle cell disease (due to lowered oxygen tension in blood)
- Acute otitis media
- Methionine synthetase deficiency
- 1st trimester pregnancy
Other contraindications: COPD, narrow angle glaucoma, pneumothorax, small obstruction, middle ear surgery, retinal surgeries
Chronic exposure/abuse of N2O-O2
May result in peripheral neuropathies
Chloral hydrate
- Sedative/hypnotic
- CNS depression – minimal CV or respiratory effect
- Mucosal irritant
- Gastric irritation a side effect; unpleasant taste
- Onset: 30-60min
- Peak: 60min
- Duration: 5hr
- Working time: up to 60min
- 10-50mg/kg PO to 1g max (as sole agent; reduced doses if used in combination w/ other sedatives)
- Metabolized to trichlorethanol in liver; excreted by kidney
- Arrhythmias in higher doses (usually >75mg/kg)
- No reversal agent
- When combined w/ other sedates, this is why CH dose should be loweer
Diazepam
- Sedative/hypnotic
- CNS depression – minimal CV or respiratory effect
- Amnesia, ataxia (acts in cortex, limbic system thalamus, hypothalamus)
- Onset: 45-60min
- Peak: 60min
- ½ life: 20-40hr
- 0.25-0.3mg/kg PO (<10mg total dose)
- Reversal: Flumazenil (0.01mg/kg and can be repeated up to a total of 1mg)
- IV preferred, but can be IM or submucosal – onset of reversal doesn’t occur for up to 1-2min assuming circulation is occurring
- Contraindications: Narrow angle glaucoma
- Half-life 20-40hr w/ sedative metabolite
Midazolam
- Sedative/hypnotic
- CNS depression – minimal CV or respiratory effect
- Anterograde amnesia potential feature
- Onset: 15min
- Working time: 30-40min
- 0.5-0.75mg/kg to 15mg total – orally
- 0.2-0.3mg/kg – nasally
- Reversal: Flumazenil (not to exceed a cumulative dose of 0.05mg/kg or 1mg, whichever is lower)
- IV preferred, but can be IM or submucosal – onset of reversal effect does occur for up to 1-2min
- 3-4x potency of diazepam
- Respiratory depression w/ higher doses or rapid IV bolus
Hydroxyzine
- Antiemetic/antihistamine
- CNS depression – anxiolytic, bronchodilator
- Analgesia – dry mouth
- Onset: 15-30min
- Duration: 2-4hr duration
- 0.5-1mg/kg orally
- Used often w/ chloral hydrate, meperidine or midazolam
Meperidine
- Narcotic
- CNS, CV, respiratory depression
- Reversal: Naloxone (0.1mg/kg; max 2.0mg)
- IV preferred, but can be IM or submucosal – onset doesn’t occur for up to 1-2min
- Sedation, analgesia, lowers seizure threshold
- Caution in patients w/
- Pulmonary complications
- Head trauma
- Seizures
- Hepatic/renal disease
- Airway obstruction
- Concomitant LA dose consideration is very important
- Onset: 30min
- Peak: 1-2hr
- Duration: 2-4hr
- 1.0-2.0mg/kg PO
- 50mg max PO, SM, IM
- Metabolized by liver, excreted by kidney
- Side effects:
- Dizziness
- Xerostomia
- Sweating
- Nausea/vomiting
- Seizures
- Respiratory depression
- NOT to be used in patients w/ h/o asthma → may shift production in respiratory tree from prostaglandins to leukotrienes which are bronchial irritants
Physiologic monitoring based on behavior: Screaming/yelling vocalizations
- Clinical signs:
- Few tears
- Controlled breathing
- Struggling against immobilization
- Pre-cordial: Take earpiece out
- Capnogaph: Not needed
- Pulse ox:
- keep stabilized
- Set upper HR limits to 230bpm
Physiologic monitoring based on behavior: Mild crying
- Clinical signs:
- Some tears, eyelids open, some ptosis
- Pre-cordial: Take earpiece out
- Capnogaph: Not needed
- Pulse ox:
- keep stabilized
- Set upper HR limits to 230bpm
Physiologic monitoring based on behavior: Quiet (responsive)
- Clinical signs:
- Eyes closed, open when requested or mildly stimulated
- Breathing WNL
- Possible occasional crying
- Pre-cordial: Earpiece in + listening, attentive to gurgling or snoring (adjust head tilt)
- Capnogaph:
- Place/monitor probe
- Monitor adequacy of ventilation paying attention to head position
- Pulse ox:
- Heightened awareness for incidence of desaturation (changing pitch of pulse ox)
- Assess ventilation + head position
Physiologic monitoring based on behavior: Quiet (unresponsive)
- Clinical signs:
- Eyes closed, partial ptosis w/ possible divergent eyes
- Does not open eyes on command
- Breathing shallow
- Subtle respiratory movements
- Pre-cordial:
- Earpiece in + listening, attentive to gurgling or snoring (adjust head tilt)
- Keen focus on airway sounds, indication of obstruction or restriction or airway
- Capnogaph:
- Be cognizant of frequency of breathing, expired concentrations of CO2 + indications of apneic episodes
- Pulse ox:
- Heightened awareness for incidence of desaturation (changing pitch of pulse ox)
- Assess ventilation + head position
- Alter passive immobilization to allow patient assessment
Basic schema for a deteriorating patient under procedural sedation
- Problem w/ ventilation – respiratory distress
- Problem w/ oxygenation – hypovolemia, hypoxia, hypercapnia
- Persistent respiratory distress + hypotension → CV arrhythmia (bradycardia)
Signs of respiratory distress in a child – sedation
- Chest breathing – non-diaphragmatic
- Nasal flaring
- Platysma flaring
- Grunting
- Rocking horse/see-saw respiratory patterns
- Use of intercostal muscles for breathing
Potential emergencies associated w/ sedation
- Respiratory rate depression or arrest
- Upper airway obstruction including laryngospasm
- Allergic reaction/overdose
- If more than 1 organ system involved (e.g. respiratory + dermatologic) epi instead of diphenhydramine
- Bradycardia and/or hypotension
- Hypoglycemia
- Ensure glucose preoperatively if concern (diabetic)
- Have source of glucose (orange juice, frosting) on hand
- Vomiting
- Right mainstem bronchus is straight compared to left mainstem and more likely to aspirate
- Seizures
SOAPME
Commonly used acronym useful in planning + preparation for a procedure.
- S – size appropriate suction catheters
- O – Adequate oxygen supply + functioning flowmeter or other devices to allow delivery
- A – Size appropriate airway equipment, including but not limited to: BMV, OPA, LMA, NPA, facemasks, endotracheal tubes
- P – Pharmacy to include basic life supporting drugs for emergency
- M – Monitors (functioning + appropriate for one level deeper than intended sedation)
- E – Special equipment such as defibrillator/AED
Nitrous usage is a safe, effective technique for:
- Reducing anxiety
- Producing analgesia
- Enhancing effective communication between patient + healthcare provider
Nitrous oxide: Properties
- Analgesic and anxiolytic
- Causes CNS depression and euphoria
- Little effect on respiratory system
- Colorless and odorless gas w/ faint sweet smell
Nitrous oxide: Safety
- Patient can respond normally to verbal commands
- Causes minimal impairment of any reflexes, thus protecting the cough reflex
- No risk of losing protective reflexes
- Pt returns to preprocedure mobility after usage
- No recorded fatalities or cases of serious morbidity when used within recommended concentration
Nitrous oxide: MOA
- Absorbed quickly → allows for rapid onset and recovery [2-3 min]
-
Analgesic effect
- Initiated by neuronal release of endogenous opioid peptides
- These activate opioid receptors and descending gamma-aminobutyric acid type A (GABAA) receptors and the noradrenergic pathways that modulate nociceptive processing at the spinal level
-
Anxiolytic effect
- involves activation of the GABAA receptor either directly or indirectly through the benzodiazepine binding site
-
Lungs
- Rapid uptake of nitrous → absorbed quickly from alveoli and held in a simple solution in the serum
- Relatively insoluble → passes down a gradient into other tissues and cells in the body like the CNS
- Excreted quickly from the lungs
-
Cardiac
- Causes minor depression in cardiac output while peripheral resistance is slightly increased → thereby maintaining the blood pressure
- Advantage when treating patient w/ cerebrovascular system
- Causes minor depression in cardiac output while peripheral resistance is slightly increased → thereby maintaining the blood pressure
Nitrous oxide: Uses in children
- Analgesia/ anxiolysis may expedite the delivery of procedures that are not particularly uncomfortable, but require that the patient not move
- Allow pt to tolerate unpleasant procedures by reducing/ relieving anxiety, discomfort, pain
- Increase reaction time and reduces pressure induced pain
- Does not affect pulpal sensitivity
- The decision to use N2O analgesia/ anxiolysis must take into consideration:
- Alternative behavioral guidance modalities
- The patient’s dental needs
- The effect on the quality of dental care
- The patient’s emotional development
- The patient’s physical considerations
- Causes most children to feel tingling/warm sensation
- Appear w/ their hands open, legs limp, trance like expression
- In some children → they don’t like the feeling of losing control
- Claustrophobic children → may find nasal hood confining/ unpleasant
Nitrous oxide: Bioenvironmental concerns
- N2O has been associated with bioenvironmental concerns bc of its contribution to the greenhouse effect
- Nitrous oxide contributes about 5% to greenhouse effect
- Only 0.35-2% of total nitrous released into the atmosphere is a result of medical applications of N2O gas
- Natural sources of nitrous
- Emitted by bacteria in soils and oceans
- Produced by burning fossil fuels and forests
- Produced by agricultural practices of soil cultivation and nitrogen fertilization
Nitrous oxide: Objectives
- Reduce or eliminate anxiety
- Reduce untoward movement and reaction to dental treatment
- Enhance communication and patient cooperation
- Raise the pain reaction threshold
- Increase tolerance for longer appointments
- Aid in treatment of the mentally/physically disable or medically compromised patient.
- Reduce gagging.
- Potentiate the effect of sedatives
Nitrous oxide: Disadvantages
- Lack of potency.
- Dependent largely on psychological reassurance.
- Interference of the nasal hood with injection to anterior maxillary region
- Patient must be able to breathe through the nose
- Nitrous oxide pollution
N2O: Indications
- A fearful, anxious, or difficult patient.
- SHCN
- A patient whose gag reflex interferes with dental care.
- A patient for whom profound local anesthesia cannot be obtained.
- A cooperative child undergoing a lengthy dental procedure.
What should be assessed in patient’s med hx before usage of N2O?
- Allergies and previous allergic or adverse drug reactions.
- Current medications including dose, time, route, and site of administration.
- Diseases, disorders, or physical abnormalities and pregnancy status.
- Previous hospitalization to include the date and purpose.
- Recent illnesses (e.g., cold or congestion) that may compromise the airway.
N2O: Contraindications
- Some chronic obstructive pulmonary diseases
- Current upper respiratory tract infections
- Recent middle ear disturbance/surgery
- Severe emotional disturbances or drug-related dependencies.
- First trimester of pregnancy
- Treatment with bleomycin sulfate
- Methylenetetrahydrofolate reductase deficiency
- Cobalamin (vitamin B12) deficiency
When should you consult MD to use N2O?
- Pt has significant underlying med condition
- Severe obstructive pulmonary disease
- Congestive heart failure
- Sickle cell disease
- Acute otitis media
- Recent tympanic membrane graft
- Acute severe head injury
- Pt is pregnant → contact their pre-natal med provider
N2O: Technique of administration
- Only administered by trained/ licensed individuals who can perform appropriate reversal response [must have training to manage an emergency if pt falls into moderate sedation]
- Or under direct supervision of [differs per state law]
- Choose the right size nasal hood
-
Flow rate → 5-6 L/min generally acceptable to most pts
- Can adjust after observation of reservoir bag
- The bag should pulsate gently with each breath and should not be either over- or underinflated
- Can adjust after observation of reservoir bag
- Introduction of 100% oxygen for 1-2 minutes followed by titration of N2O in 10% intervals is recommended
- Nitrous concentration should not exceed 50%
- Studies have demonstrated that gas concentrations dispensed by the flow meter vary significantly from the end-expired alveolar gas concentrations; it is the latter that is responsible for the clinical effects.
- For sedated effect:
- Prevent pt from talking and mouth breathing
- The scavenging vacuum should not be so strong as to prevent adequate ventilation of the lungs with N2O
- 30-40% N2O to achieve ideal sedation
- Decrease N2O concentration for easier procedures, and increase for harder
- Always monitor pts respiratory rate and level of consciousness
- Effects of nitrous dependent on psychological reassurance
- Important to continue behavior guidance during tx
- After tx completed → administer 100% oxygen until pt has returned to pretreatment status
N2O: Monitoring
- Pt’s response to commands → serves as a guide to their level of consciousness
- Continual clinical observation of the patient’s responsiveness, color, and respiratory rate and rhythm must be performed
N2O: Adverse effects
- Acute/chronic adverse effects is rare
- Most common adverse effects: nausea and vomiting [0.5-1.2% of pts]
- Higher incidence noted w:
- Longer admin of nitrous
- Fluctuations in nitrous oxide levels
- Lack of titration
- Increased concentrations of nitrous oxide
- A heavy meal prior to administration of nitrous oxide
- Fasting isn’t necessary, but can recommend lighter meal before admin
- Higher incidence noted w:
- Other less common adverse effects
-
Silent regurgitation and silent aspiration are rare but occur
- Concern lies whether pharyngeal- laryngeal reflexes remain intact
- Avoid this problem by not allowing pt to go into unconscious state
-
Diffusion hypoxia
- Can occur as a result of rapid release of nitrous oxide from the bloodstream into the alveoli, thereby diluting the concentration of oxygen
- Can lead to headache, disorientation, and nausea
- Can be avoided by administering 100% O2 when the nitrous has been terminated
-
Silent regurgitation and silent aspiration are rare but occur
- Negative outcomes associated with N2O >50% and as an anesthetic during major surgery
N2O: Documentation
- Get informed consent prior to administration of nitrous
- Pts record should include indication for nitrous, the dosage, duration of procedure and post tx oxygenation procedure
N2O: Facilities, personnel, equipment
- Inhalation equipment must have the capacity for delivering 100%, and never less than 30%
- Inhalation equipment must have a fail-safe system that is checked and calibrated regularly according to the practitioner’s state laws and regulations
- Must have an appropriate scavenging system to minimize room air contamination and occupational risk
- Because moderate sedation may occur, practitioners should have the appropriate training and emergency equipment to manage this
- An emergency cart should be readily available
- Should have equipment to resuscitate a non-breathing, unconscious pt and provide continuous support until ER personnel arrive
- A positive pressure oxygen delivery system capable of administering greater than 90% oxygen at a 10 L/min flow for at least 60 minutes (650 L, “E” cylinder) must be available
N2O: Occupational safety
- Long-term exposure to N2O used as a general anesthetic has been linked to bone marrow suppression and reproductive system disturbances
- Appropriate scavenging is effective in reducing the reproductive system effects
- To avoid health hazards → use effective scavenging systems
- Clinicians should try to minimize the patient’s talking and mouth breathing during N2O administration to prevent expired gas from contaminating the operatory
What has long-term N2O exposure as a general anesthetic been linked to?
Bone marrow suppression + reproductive system disturbances
What medicaments should be used as first line interventions for pain management?
APAP (acetaminophen)/NSAIDs
Pain: Definition
-
Pain: (International Association of the Study of Pain) An unpleasant sensory + emotional experience associated w/ actual or potential tissue damage or described in terms of such damage.
- Acute
- Chronic
- Subjective, emotional, cultural component
Gate Theory of Pain
- Melzack + Wall – 1965
- The substantial gelatinosa in dorsal horn acts as a “gate” which modulates transmission of sensory information from primary afferent neurons to transmission cells in spinal cord
- Small-fiber activity “opens” gate while large-fiber activity “closes” gate
- Descending pathways modify gate – activation of large fiber sensory neurons can modify pain perception
What are infants + young children more sensitive to pain?
- Ascending pathways intact allowing full transmission of pain
- Descending modulating pathways poorly developed + unable to attenuate pain
- Do not have cognitive skills to modulate pain
What are effects of improperly managed pain?
- Significant stress rxn w/ ⇡in catecholamines, corticosteroids, suppression of insulin, significantly more complications post-operatively
- Long-term neurologic change
- Changes in brain achitecture
- Changes in dorsal horn (plasticity) → hyperalgesia later in life
- Plasticity acts as implicit memory of pain
What patients are at higher risk of experiencing pain?
- H/o uncontrolled procedural pain or h/o frequent medical intervention
- Infants + very young children
- H/o prematurity
- Past h/o physical, sexual, or psychological abuse
Wong-Baker FACES Pain Scale
Self-reported pain scale – Children >3yo
Visual Analogue Scale
Self-reported pain intensity scale – Children >6yo
FLACC
- FLACC = Faces, Legs, Arms, Crying Consolability Scale
- Observational pain scale for children + adults
- Requires trained observer
Sucrose + Non-Pharmacologic procedural pain management
- Effective for minor pain in young infants
- Sucrose has same pathway as opioids; efficacy wanes at 6mo
Ice precooling injection site vs. benzocaine
Ice precooling has been shown to be more effective than benzocaine
Topical anesthetic effect – What is the depth of the effect?
-
Pharmacologic + psychological
- Effective on surface up to 2-3mm
- Subjects who are told they will receive topical for comfort anticipate less pain
How may topical anesthetic be most effective?
- Dry mucosa
- Longer duration is more effective (5min > 2min > 30 sec)
- More effective in buccal fold than on palatal tissue OR for deep tissue injections
What type of anesthetic is topical benzocaine (up to 20%)?
Ester
What is the reason for the FDA warning w/ benzocaine?
- Children <2yo (i.e. teething gels) due to methemoglobinemia
- Ferrous iron in the hemoglobin molecule is oxidized to the ferric state to become methemoglobin
- Cannot carry O2
What other types of topical anesthetic may be used?
20% benzocaine, 5% lidocaine, 4% tetracaine
Compound topical anesthetics
- Not regulated by FDA
- FDA issued warning about use of compounded topical anesthetics + risk of methemoglobinemia w/ benzocaine and/or prilocaine
- Various formulations (usually higher doses) of tetracaine, lidocaine, benzocaine, prilocaine, and/or phenylephrine
- Systemic absorption of topical anesthetics must be considered when calculating the total amount of anesthetic dosage administered
LA MOA
Reversibly bind to Na+ channels of nerve cells preventing depolarization + impulse propagation
2% lidocaine (xylocaine) 1:100k epi: Duration, Max dosages, mg/1.7mL cartridge
- Duration (in minutes)
- Max infiltration
- Pulp = 60
- Soft tissue = 170
- Mand block
- Pulp = 85
- Soft tissue = 190
- Max infiltration
- Max dosage = 4.4mg/kg – Total = 300mg
- mg/1.7mL cartridge = 34mg
3% mepivacaine (carbocaine) plain: Duration, Max dosages, mg/1.7mL cartridge
- Duration (in minutes)
- Max infiltration
- Pulp = 25
- Soft tissue = 90
- Mand block
- Pulp = 40
- Soft tissue = 165
- Max infiltration
- Max dosage = 4.4mg/kg – Total = 300mg
- mg/1.7mL cartridge = 51mg
4% articaine (septocaine) 1:100k epi: Duration, Max dosages, mg/1.7mL cartridge
- Duration (in minutes)
- Max infiltration
- Pulp = 60
- Soft tissue = 190
- Mand block
- Pulp = 90
- Soft tissue = 230
- Max infiltration
- Max dosage = 7.0mg/kg – Total = 500mg
- mg/1.7mL cartridge = 68mg
4% prilocaine pain: Duration, Max dosages, mg/1.7mL cartridge
- Duration (in minutes)
- Max infiltration
- Pulp = 20
- Soft tissue = 105
- Mand block
- Pulp = 55
- Soft tissue = 190
- Max infiltration
- Max dosage = 6.0mg/kg – Total = 400mg
- mg/1.7mL cartridge = 68mg
0.5% bupivacaine (marcaine) 1:200k epi: Duration, Max dosages, mg/1.7mL cartridge
- Duration (in minutes)
- Max infiltration
- Pulp = 40
- Soft tissue = 340
- Mand block
- Pulp = 240
- Soft tissue = 440
- Max infiltration
- Max dosage = 1.3mg/kg – Total = 90mg
- mg/1.7mL cartridge = 8.5mg
Epi in LA
- ⇓bleeding in area of injection
- ⇓toxicity by slowing rate of resorption of anesthetic into CV system
- Recommended, esp when tx includes 2+ quadrants
What is the preservative in LA that patients may have an allergic rxn to? What do we give for LA to patients w/ this allergy?
Bisulphite preservative is used in anesthetics w/ epi.
Use anesthetic w/o epi in patients w/ this allergy.
Contraindication] for epi in LA?
Hypothyroidism
When should you send a med consult for use of LA?
- Diabetes
- Significant CV disease
- Thyroid dysfunction
- Patients on tricyclic antidepressants, monoamine oxidase inhibitors, phenothiazines
Where is articaine (septocaine) metabolized?
Liver + plasma
Has the shortest half-life
FDA approval for use of articaine (septocaine) in children at what age?
≥4yo
Which amide LA is associated w/ paresthesia?
Articaine (septocaine) + prilocaine
What amide LA is associated w/ a disproportionate number of pediatric LA systemic toxicity reports?
Mepivacaine (carbocaine)
Indications for mepivavaine (carbocaine)?
- Significant CV disease
- Hyperthyroidism
- Bisulphite sensitivity
Prilocaine
- Can induce formation of methemoglobinemia
- W/o vasoconstrictor has a higher pH than lidocaine, but no difference in injection pain
Contraindications for prilocaine use
- Patients w/ various anemias
- Symptoms of hypoxia
- Taking acetaminophen
Why is bupivacaine (marcaine) not typically used in pediatric dental patients?
Due to the long duration of soft tissue anesthesia + ⇑risk of post-operative soft tissue trauma
Indication for bupivacaine (marcaine)?
Anticipated post-op pain OR for adolescent patient w/ a “hot” tooth
Infiltration vs. block (in relation to the nerve)
Infiltration = terminal branches of nerve
Block = main nerve trunk
IANB
- Innervates primary + permanent mandibular teeth
-
Foramen is 7mm above mandibular plane in adults
- More inferior + posterior in young children
- Bilateral blocks are not associated w/ ⇑post-anesthetic soft tissue trauma
PSA nerve block
- Advocated by some for 2nd primary + 1st permanent molars in primary + early mixed dentition due to thick zygomatic bone that overlies apices
- Highest risk of hematoma
- Efficacy over infiltration has been questioned
Greater palatine block
- Anesthetizes palatal tissue from tuberosity to canine region
- Indicated for EXT, long procedures where palatal gingiva is manipulated, or when post-op analgesia is needed
-
Level w/ distal cusp of permanent 1st molars + between tooth and midline of palate
- If no 1st permanent molar present, injection should be made 10mm distal to primary molar
If no 1st permanent molar is present, where should you drop LA for greater palatine block?
If no 1st permanent molar present, injection should be made 10mm distal to primary molar