Section 6: Nervous co-ordination Flashcards
How is the resting potential established?
-
Sodium potassium ion pump actively transports
- 3 sodium ions out of the axon
- 2 potassium ions into axon
- Electrochemical gradient established - higher conc of K+ ions in axon
- Membrane more permeable to potassium ions (K+ channels open/ Na+ channels closed)
- K+ ions move out of axon by facilitated diffusion. Therefore inside more negative than outside. Axon is polarised - resting potential
What is the stimulus in membrane permeability leading to depolarisation?
- Membrane more permeable to Na+ ions as the channels open
- Sodium diffuse into neurone down electrochemical gradient
What is depolarisation part of the graph mean?
- P.d reaches threshold, action potential generated
- Because more voltage-gated sodium ion channels open and sodium diffuse rapidly
What is repolarisation part of the graph mean?
- Sodium ion channels close (membrane less permeable to sodium ions) whilst voltage gated potassium ion channels open so potassium ion s diffuse out of neurone
What is hyperpolarisation part of the graph mean?
- Potassium ion channels are slow to close so there is a slight overshoot - too many potassium ion diffuse out of neurone
What is the importance of the refractory period
- The refractory period is the time to restore axon to resting potential/ no further action potential can be generated
- Importance:
- Produces discrete impulses - action potentials cant overlap
- Limits frequency of transmission at a certain intensity
- Unidirectional action potential
What are the factors that affect the speed of conductance?
- Myelination
- Axon diameter
- Temperature
How does Myelination affect the speed of conductance?
- Depolarisation occurs at nodes of Ranvier only - saltatory conduction
- Impulse does not travel whole axon/ no need to depolarise along whole length of axon
How does the axon diameter affect the speed of conductance?
- Bigger diameter means less leakage of ions/ less resistance to the flow of ions
How does temperature affect the speed of conductance?
- Increases rate of movement of ions Na+ and K+ as more kinetic energy
- Higher rate of respiration so ATP is produced faster - active transport faster
- But proteins could denature at a certain temperature
What is the passage of an action potential along non-myelinated axons
- Action potential passes as a wave of depolarisation
- Influx of sodium ions in 1 region increases permeability and causes voltage gated sodium ion channels to open so region depolarises
What is the passage of an action potential along a myelinated axon?
- Depolarisation of an axon at nodes of ranvier only
- Resulting in saltatory conduction
- So there is no need for depolarisation along whole length of axon
What is the passage of an action potential along a myelinated axon?
- Depolarisation of an axon at nodes of ranvier only
- Resulting in saltatory conduction
- So there is no need for depolarisation along whole length of axon
Exam Question: Damage to the myelin sheaths of neurones can lead to problems controlling the contraction of muscles. Suggest 1 reason why? (2)
- Action potentials travel more slowly/ no saltatory conduction
- So delay in muscle contraction/ muscles dont contract
OR
- Action potentials/ depolarisation “leaks” to adjacent neurones
- So wrong muscle contracts
What is the sequence of steps of the transmission across a cholinergic synapse?
- Action potential arrives causing calcium ion channels to open - calcium ions diffuses into pre-synaptic neurone
- Causing vesicles of neurotransmitters/ acetylcholine to fuse to pre-synaptic membrane - release acetylcholine into synaptic cleft (exocytosis)
- Neurotransmitters diffuse across synaptic cleft - bind to neurotransmitter receptors on post synaptic membrane
- Sodium ion channels open - sodium ions diffuse into post-synaptic knob - depolarisation initiates action potential
- Neurotransmitter removed from cleft so response does not keep happening - broken down by acetylcholinesterase and products reabsorbed by presynaptic neurone.