Section 6:Homeostasis Flashcards
Define homeostasis with examples
The maintenance of a constant internal environment. Factors:temperature,concentration of glucose,water potential and concentration of ions (pH)
What is the optimum point?
The pont at which system operates best
Define feedback mechanism
By which a receptor respondes to a stimuli,created by a change to the system brought about by the effector
Involved when gluocse concentration is too high
How does insulin affect glucose concentartion?
- Insulin binds to specific receptors on cell membrane of liver and msucle cells
- Increase permability of muscle-cell membranes to glucose=cells take up more glucose~involves increasing no. of channel protwina
- Insulin activates enzymes liver and msucle cells glucose into glycogen (glycogenesis)
- Cells able to store glycogen as energy source
- Increase rate of respiration of glucose
How does glucagon affect blood glucose concentration?
- Glucagon binds to specific receptors on cell membrane of liver cells
- Glucagon activates enzymes in liver cells which break down glycogen into glucose (glycogenoysis)
- Glucoagon activates enzymes that are involved in formation of glucose from glycerol
- Glucoagon decreases the rate of respiration of glucose in cells
What is involved in any self-regulating system?
- Optimum point
- Receptor
- Coordinator
- Effector
- Feedback mechanism
Describe the characteristics of a hormone
- Produced in glands,which secreate the hormone dircetly into the blood
- Blood plasma to the cells on which they act (target cells)~have specific receptors
- Effective in low concentrations, but often have widespread and long-lasting effects
What are the islets of langerhans?
Group of hormone-producing cells
* Alpha cells~larger and produce the hormone glucagon
* Beta cells~smaller and produce the hormone insulin
What are the three processes that are associated with regulating blood sugar?
Takes place in the liver
- Glycogenesis=Glucose into glycogen (high blood glucose conc)
- Glycogenolysis=Breakdown of glycogen to glucose (low blood glucose conc)
- Gluconeogenesis=Production of glucose from sources other than carbohydrates
Describe the second messenger model
- Hormone adrenaline approaches transmembrane protein
- Adrenaline fuses to the receptor=Changes shape on the inside of the membrane~Activates an enzyme within membrane
- Activated emnzyme converts ATP to cyclicr AMP
- cAMP in turn changes the shape of and activates protein kinase enzyme
- The activate protein kinase enzyme catalyses the conversion of glycogen to glucose
Describe the role and characteristics
A gland which produces enzymes
Produces the hormones insulin and glucagon (produced by the islets of langerhans)~islets secreate these hormones
What are the three sources of glucose?
- Directly from the diet in the form of glucose~hydrolysis of carbs
- Hydrolysis of glycogen stored in the liver and muscle cells
- Gluconeogesis
How does insulin lower blood glucose concentration levels?
- Increased rate of absorption of glucose into cells
- Increased rate of respiration
- Increased rate of conversion of glucose to glycogen
- Increasing the rate of conversion of glucose to fat
How does glucagon increase blood glucose concentration levels?
- Attach to specific proteins on cell surface membrane of liver cells
- Activates enzymes that convert glycogen to glucose
- Activates enzymes involved in the conversion of amino acids and glycerol to glucose