Section 3:Mass transport Flashcards
What is haemoglobin made up of?
Protein/polypeptide chains
General protein structure
What is the structure of haemoglobin chains?
- Primary=sequence of AAs
- Secondary=in which each polypeptide chain is coiled into a helix
- Tertiary=in which each polypeptide chain is folded into a precise shape
- Quaternary=in which all polypeptide chains are linked together
Two β-polypeptide chains and two α-polypeptide chains
What is associating/dissociating and where does it take place?
Associating=haemoglobin binds to oxygen and takes place in the lungs
Dissociating=haemoglobin releases its oxygen and takes place in the tissues
What does it mean if haemoglobin has a high or low affinity for oxygen?
Haemoglobin with a high affinity for oxygen takes up oxygen more easily,but release it less easily
What must haemoglobin do to be efficient at transporting oxygen?
- Readily associate with oxygen at the surface where gas exchange takes place
- Readily dissociate from oxygen at those tissues requiring it
What is positive cooperativity?
The binding of the first oxygen molecule changes the quaternary structure of the haemoglobin. This induces the other subunits to bind to an oxygen molecule. Therefore, it takes a smaller increase in the partial pressure of oxygen to bind to the second oxygen molecule, than it did for the first oxygen molecule
What does it mean if the oxygen dissociation curve is further to the left or right?
- Left=haemoglobin has a higher affinity for oxygen
- Right=haemoglobin has a lower affinity for oxygen
How does the carbon dioxide concentration affect haemoglobin’s affinity for oxygen?
Haemoglobin has a reduced affinity for oxygen in the presence of carbon dioxide
* Lungs=low conc=increased affinity
* Muscles(respiring tissues)=high conc=decreased affinity
How does a low concentration of carbon dioxde affect the structure of haemoglobin?
- pH is raised due to the low conc
- The higher pH changes the shape of haemoglobin into one that enables it to load oxygen readily
- The shape also increases the affiinity of haemoglobin for oxygen~this means oxygen is not released while being transported in the blood to the tissues
Six points
Explain why there is always enough oxygen for respiring tissues?
Excerise
- Higher rate of respiration
- More carbon dioxide produced
- Lowers the pH
- Greater the haemoglobin shape changes so decreases its affinity for oxygen
- Oxygen is more readily dissociated
- More oxygen is available for respiration
Why do large organisms need a transport system?
Increasing size leads to decrease in SA:V for exchange. As a result it can no longer rely on simple diffusion and needs to develop specialist gas exchange systems
What are good features of a transport system with examples within animals?
- Suitable medium=to carry materials (Blood)
- Closed system of tubular vessels=contains transport medium (Blood vessels)
- Mechanism to maintain the mass flow in one direction(Valves)
- Mechanism to control the flow of the transport medium(Valves)
- Mechanism for moving the transport medium within vessels(Muscular contraction of the heart)
How can you describe the mamilian circulatory system?
Closed double circulatory system
Where do the different sides of the heart pump blood to?
- Right=pumps blood to the lungs
- Left=pumps oxygenated blood rapidly around the body at high pressures
How does the structure of the atria relate to its function?
- Thin muscular walls=only has to pump blood to the ventricles
- Elastic walls=able to strech as it collects blood