Section 2 - Data Interpretation

Question 1

Which two drugs can cause neutropenia?

Answer 1

Clozapine

Carbimazole

Question 2

Which drugs can cause thrombocytopenia?

Answer 2

Penicillinamine (RA)

Heparin (increased destruction)

Question 3

What drugs can cause cholestasis?

Answer 3

Fluclox + co-amox
Nitrofurantoin
Steroids
Sulphonylureas

Question 4

What are some features of digoxin toxicity?

Answer 4

Confusion
Nausea
Visual disturbances
Arrhythmias

Question 5

What are some features of lithium toxicity?

Answer 5

Early –> tremor
Intermediate –> tiredness
Late –> arrhythmia, seizures, renal failure, nephrogenic DI

Question 6

What are some features of phenytoin toxicity?

Answer 6

Gum hyperplasia
Ataxia, nystagmus
Peripheral neuropathy

Question 7

What are some features of gentamicin toxicity?

Answer 7

Ototoxicity

Nephrotoxicity

Question 8

What are some features of vancomycin toxicity?

Answer 8

Ototoxicity

Nephrotoxicity

Question 9

What abx are oto- and nephrotoxic?

Answer 9

Gentamicin, vancomycin

Question 10

What is the regimen used for gentamicin?

Answer 10

5-7 mg/kg OD

Renal failure / IE –> 1 mg/kg

Question 11

How do you interpret nomogram for gentamicin?

Answer 11

Within 24 hour area –> continue at same dose
36hr / 48 hr –> change to that time frame
Above 48hr –> repeat gentamicin level and re-dose when concentration <1mg/L

Question 12

INR < 6 - how do you manage warfarin dose?

Answer 12

Reduce

Question 13

INR 6-8 - how do you manage warfarin dose?

Answer 13

Omit for 2 days then reduce dose

Question 14

INR > 8 - how do you manage warfarin dose?

Answer 14

Omit warfaring and give vit K

Question 15

Patient is on salbutamol - what do you check?

Answer 15

Are they on inhalers? Nebs? Should not be on both for fear of toxicity