Section 1B

Question 1

increased plasma glucose concentration stimulates

Answer 1

facilitated diffusion of glucose into pancreatic beta-cells in pancreatic islets

Question 2

increased intracellular glucose concentration stimulates glycolysis within

Answer 2

beta-cells

Question 3

because the rate of intracellular NADH production is proportional to the rates of glycolysis and tricarboxylic acid cycling, intracellular NADH concentration __________ and induces increased synthesis and secretion of insulin by _________

Answer 3

increases

pancreatic beta - cells

Question 4

insulin gets secreted into circulation by:

Answer 4

the pancreas

Question 5

once in circulation, insulin acts to :

Answer 5

stimulate glucose uptake by GLUT4 transporter in myocytes and adipocytes
glycogenesis in hepatocytes and myocytes
glycolysis (decreasing intracellular free glucose and providing pyruvate for lipogenesis)
adipocyte lipoprotein lipase activity (increasing triglyceride storage in adipocytes)
amino acid uptake and protein synthesis in liver and muscle

Question 6

Insulin acts to inhibit

Answer 6

glycogenolysis, gluconeogenesis from amino acids, and adipocyte hormone sensitive lipase (decreasing lipolysis of stored triglycerides)