Secondary lymphoid tissues

Question 1

What are the secondary lymphoid tissues?

Answer 1

Lymph vessels, lymph nodes, spleen and MALT

Question 2

What does MALT stand for?

Answer 2

mucosa associated lymphoid tissue

Question 3

What are the secondary lymphoid tissues in terms of lymphocytes?

Answer 3

The site where mature lymphocytes are exposed to and stimulated by antigen

Question 4

Another name for secondary lymphoid tissue

Answer 4

Peripheral lymphoid organs

Question 5

Is migration of lymphocytes from primary to secondary random or highly specific?

Answer 5

Highly specific

Question 6

What do lymphocytes enter secondary tissues via?

Answer 6

HEVs

Question 7

What is diapedesis?

Answer 7

Squeezing of lymphocytes through endothelium into nodes

Question 8

do lymph vessels have valves?

Answer 8

Yes, ensure unidirectional flow without a pump

Question 9

function of lymph vessels

Answer 9

drain tissue fluid from connective tissues. drain to lymph nodes

Question 10

Where are lymph nodes saturated?

Answer 10

Groin and neck

Question 11

Describe lymph nodes

Answer 11

Highly organised, bean shaped junctions between lymph vessels

Question 12

function of lymph nodes

Answer 12

To filter lymph

Question 13

Describe flow in lymph nodes

Answer 13

enter via afferent lymphatics to cortex, pass through paracortex, exits via efferent lymphatics in medulla.

Question 14

Where do HEVs enter the lymph nodes?

Answer 14

Paracortex

Question 15

Where are B cells found in the lymph nodes?

Answer 15

primary and secondary follicles in the cortex

Question 16

Where are T cells found in the lymph nodes?

Answer 16

Paracortex

Question 17

How big is the spleen?

Answer 17

fist sized

Question 18

location of the spleen

Answer 18

Associated posteriorly with the 9-11th ribs but separated from them by the diaphragm superiorly.

Question 19

Relationship between spleen and pancreas

Answer 19

The tail of the pancreas points to the spleen

Question 20

Relationship between the spleen and large intestine

Answer 20

It rests on the left colic flexure of the large intestine

Question 21

function of spleen

Answer 21

collects antigen from blood and presents to lymphocytes, filters blood and removes and disposes of ageing red blood cells and immune complexes.

Question 22

What are the two internal structures of the spleen?

Answer 22

Red pulp and white pulp

Question 23

What is red pulp?

Answer 23

well perfused tissue of the spleen for filtration

Question 24

What is white pulp?

Answer 24

similar to lymph nodes, packed with B and T cells and dendritic cells

Question 25

Where are T cells located in white pulp?

Answer 25

in periarteriolar lymphoid sheaths- PALS

Question 26

Where are B cells located in white pulp?

Answer 26

beyond sheath in a corona around the germinal centres.