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P** > SE > Flashcards

SE Flashcards

1
Q

Neuro/epilepsy drugs which cause myelosuppression/agranulocytosis

A

Phenytoin
Crbamazepine
Antipsychotics

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2
Q

Immunosuppressant drugs which cause myelosuppression/agranulocytosis

A

Azathioprine
Methotrexate
Interferon-alpha

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3
Q

Other drugs (not neuro/rheum) which cause myelosuppression/agranulocytosis

A

Carbimazole
Thiazides
Ganciclovir
Chloramphenicol

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4
Q

Drugs which cause tardive dyskinesia?

A

Levodopa
Antipsychotics
Phenytoin

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5
Q

Fusidic acid

A

Cholestatic (can cause jaundice)

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6
Q

Ca channel blockers

A

Flushing,

Bradycardia (verapamil and diltiazem),

Ankle swelling (dihydropiridines)

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7
Q

PPAR gamma receptor antagonists (thiazolidinediones) eg. pioglitazone

A
  • Weight gain
  • Liver impairment: monitor LFTs
  • Fluid retention - therefore contraindicated in heart failure.
  • Increased risk of: fractures, bladder cancer
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8
Q

Phenytoin

A

everything….

Acute:
• Headaches
• Confusion, heading to seizures

Chronic (dose dependent):
•	Facial coarsening
•	Gum hyperplasia
•	PDGF induction
•	Alters folate (megaloblastic anaemia) and vit D metabolism (osteomalacia)
•	Dyskinesia
•	Lymphadenopathy

Idiopathic:
• Dupuytren’s contracture
• Hepatitis

Teratogenic:
• Cleft palate
• Congenital heart defect

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9
Q

Drugs which cause jaundice?

A

Pre-hepatic:
• Causes of haemolysis - chemo or malaria drugs)
• Impaired uptake of bilirubin - inhibited by rifampicin and radio-contrast agents

Hepatic:
•	Paracetamol (hepatitis)
•	TB drugs except for ethambutol (ison, rifamp, pyramidazine)
•	Halothane
•	Statins
•	MAOIs
•	Valproate
Post-hepatic:
•	Chlorpromazine & prochlorperazine
•	Lots of antibiotics: fluclox, co-amoxiclav, fusidic acid
•	Sulphonylureas
•	Steroids
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10
Q

Quinolone (eg. moxi/levo/o - flaxacin/fluroquinolone)

A

Decreased seizure threshold

Tendon damage - mainly in animal studies, limited evidence

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11
Q

Sulphonylureas

A

Can cause hypos (whereas metformin doesn’t)

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12
Q

B-blockers and diabetes?

A

Reduced awareness of hypos

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13
Q

SEs of ergot-derived dopamine agonists (bromocriptine and cabergoline)?

A

Cardiopulmonary retroperitoneal fibrosis

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14
Q

New dopamine agonists?

A

Ropinerol

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15
Q

Osteonecrosis of the jaw is most characteristically caused by?

AceI
Amiodarone
Phenytoin
Bisphosphonates
Warfarin
Slidenafil
A

Bisphosphonates.

Adverse effects of bisphosphonates:
• Oesophagitis (upto 25%)
• Oesteonecrosis of the jaw
• Increased risk of atypical stress fractures of the proximal femoral shaft in pts taking alendronate

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16
Q

Which of the following drugs does not have dizziness as a side effect?

Phenytoin
Carbamazepine
Bisphosphonates
Amantidine
Nicorandil
A

Bisphosphonates

P** (14 decks)

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