Scleroderma, Inflam Myopathies Flashcards
(“What is the distinguishing hallmark of Systemic Sclerosis (SSc)?”
“Thickened skin”)
(“What are the three cardinal features of SSc?”
“Vasculopathy
(“Which antibody is associated with scleroderma renal crisis?”
“Anti-RNA Polymerase III”)
(“What type of T-helper cells promote a pro-fibrotic environment in SSc?”
“TH2 cells”)
(“What is the end result of vascular injury and fibroblast activation in SSc?”
“Fibrosis”)
(“What internal organ disease is present in systemic but absent in localized scleroderma?”
“Internal organ disease”)
(“What are scleroderma-specific autoantibodies?”
“Antibodies to Centromere
(“What is the difference in skin involvement between limited and diffuse cutaneous SSc?”
“Limited affects fingers
(“What pulmonary condition is common in systemic sclerosis?”
“Interstitial lung disease and pulmonary arterial hypertension”)
(“What antibody is specific for MCTD?”
“Anti-RNP antibody”)
(“Which autoimmune diseases overlap in MCTD?”
“SLE
(“What is pathognomonic for dermatomyositis?”
“Gottron’s papules and heliotrope rash”)
(“What test is used to assess tear production in Sjögren’s syndrome?”
“Schirmer’s test”)
(“What are the three components of the triad in Sjögren’s syndrome?”
“Xerostomia
