Schizophrenia and Other Psychotic Disorders Flashcards

1
Q

What are the 4 criteria for diagnosing Schizophrenia?

A

Criteria A: Active Phase signs and sx

Criteria B: Social occupational dysfunction: how bad is it?

Criteria C: Time duration

Criteria D: Another diagnostic explanation

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2
Q

What is Criteria A?

What is required to meet Criteria A?

A

Criteria A = Signs and Symptoms

  1. Hallucinations
  2. Delusions
  3. Disorganized thinking
  4. Disorganized behavior
  5. Negative symptoms

Need two symptoms, o_n_e which must be a “positive” symptom (hallucination, delusion or disorganized thinking, disorganized behavior)

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3
Q

What is psychosis

what types of experiences/symptoms does the patient experience?

A

Grossly impaired reality testing

Persons incorrectly evaluatel teh accuracy of their perceptions and thoughts and make incorreect inferences about external reality, even in the face of contrary evidence

Psychosis commonly means the patient is experiencing DELUSIONS and HALLUCINATIONS, refered to as POSITIVE symptoms of schizo.

Disorganized thinking = psychotic thinking, or psychosis, is also a positive symptoms

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4
Q

What are hallucinations?

what are the types of hallucinations that exist? which is the most common?

When can hallucinations not be pathological?

A

Hallucinations are perceptions without stimuli (perceived senses with no stimuli - you see something but there is nothing there, you feel something that isn’t there, you hear sounds that are non-existant)

Auditory = hearing voices, most common

Visual = seeing things, second most common

Tactile, feeling things that are not there, such as bugs on or under one’s skin; not as common, can be seein in substance withdrawal syndromes

Gustatory and olfactory are rare; perhaps with neuro involvement or connected with an aura

**The person needs to be fully awake! Hypogogic and hypomonic (night/morning) are not necessarily pathological since the person might not be fully awake

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5
Q

What are delusions?

What types of delusions occur?

How can we approach a delusional patient?

A

Delusions = unfounded, unrealistic BELIEFS that is held withouth supporting evidence and are not amenable to change when conflicting evidence is presented; person is convinced that whaty they belive is true - can often lead to conflict with others

DELUSIONS ARE THOUGHTS perceived to be 100% true

Non-bizarre delusions - thoughts with a certain amount of plausibility when you first hear about it but then it becomes less plausible with time; but they are 100% sure that it is happening and do not consider other possibilities (ie - my SO is being unfaithful, I am being watched/monitored, harassed by my neighbors)

Bizarre delusions- clearly impossible, not understandable and/or do not derive from ordinary life experiences. Usually easy oto identify though can be difficult to judge situations involving diff cultures (ie- my SO is being unfaithful with Elvis, currently; Alien controlled neighbors are monitoring/harassing me)

Approach: collateral hx, ask about “conflicts” they may currently be having

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6
Q

What is disorganized thinking?

What are the different types?

Derailment vs tangenital speech

A

Disorganized thinking = sx that substantially impair effective communication, infered primarily upon the individual’s speech

Derailment = person talking about a topic…derails/stops…resumes on a different topic; there is loose associations, person slips off track from one topic to another topic, while the associations btw topics is weak/unclear

Tangential Speech = answers are unrealted or only vaguely related to the question, incoherent or word salad = severely disorganized speech, nearly incomprehendable

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7
Q

What is disorganized behavior?

What theme surrounds this sx?

A

Disorganized behavior = grossly disorganized, seen in wide range of possible behaviors. Childlike silliness to upredictable agitation, problems with any form of goal directed behavior - can lead to difficult performing activities of daily living (meal prep, maintaining personal hygiene)

Many times the theme around disorganized behavior is social impairment, caused by decreased daily activities

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8
Q

What are negative symptoms?

What criteria must be met?

A

Only need to have 1 negative symptoms to qualify as having neg. symptoms

  • Affective flattering: lack of emotion, interpersonal emotional cues (facial expresison, eye contact, body language) are lacking
  • Alogia - poverty of speech; brief, laconic, empty replies
  • Avolition - lack of motivation; inability to initiate and persist in goal direct activities
  • Anhedonia - lack of pleasure; unable to enjoy activities
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9
Q

What is criteria B signify?

What is meant by the downward drift hypothesis? relate this with the # of schizophrenics in lower socio-economic groups and within the homeless population

A

Social Occupational Dysfunction, how bad is it?

For a signifiacnt portion of the time since the onset of the disturbance, ONE OR MORE major areas of functioning - work, interpersonal relationships or self-care - are markedly below the level achieved prior to the onset (OR if the onset is in childhood / adolescence, failure to achieve expected level of interpersonal, academic or occupational achievement)

Downward Drift Hypothesis: hypothesizes that the social-occupational dysfunction of schizophrenia results in those who start out with resources available but gradulaly lose them and “drift downward” into the low socio-economic group.

  • A disproportionate number of people with schizoprenia are in the low socio-economic group*
  • 33% of homeless population have schizophrenia*
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10
Q

What is Critera C?

If criteria C is NOT met, what could this otherwise signify?

A

Criteria C = Time Duration

continuous signs of the disturbance that persists for at least SIX months - criteria A does NOT need to be met for the entire time; at least ONE MONTH where criteria A (active phase symptoms) is met

If duration of sx is < 1 month = brief psychotic disorder / psychosis NOS (non otherwise specified)

If duration lasts 1 mo < sx < 6 months- schizophreniform

Onset of illness - prodromal phase = gradual onset and building of symptoms of schizophrenia; often it is not realized until the symptoms have gotten serioud (first break of pychosis) that the behaviours were abnormal and part of a prodromal phase

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11
Q

What does Criteria D require?

According to Criteria D, what are other possibilities (6):

A

Criteria D ensures that another diagnositc explanation is not the cause of the symptoms.

What are other possibilities:

  1. Another psychotic disorder - schizoaffective disorder, delusional disorder, schizophreniform disorder, brief psychotic disorder, psychosis N.O.S
  2. Mood disorder with psychosis - bipolar disorder w/ psychotic features, MD with spychotic features
  3. Psychosis due to a substance - substance intoxication/withdrawal, psychosis secondary to medication rxn
  4. General medical condition -any medical illenss that effects the CNS - neurological, endocrine, metabolic
  5. Developmental disorders - autism, Rhett’s disorder, Asperger’s
  6. Personality disorders - Cluster A paranoid, schizoid, schizotypal
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12
Q

What is schizoaffective disorder?

A

It is a psychotic disorder that could be another diagnostic explanation.

A major mood episode (MD, bipolar) is concurrent with Criteria A.

Major mood symptoms are present for the majority of the total duriation of the illness. At least TWO WEEK period of hallucinations/delusions WITHOUT mood symptoms present.

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13
Q

What is delusional disorder?

A

Bizzare or non-bizzare delusion; most common - persecutory, jealousy

Sx for at least ONE MONTH and do not meet criteria A for schizophrenia

No real mood symptoms or present for a brief period of time

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14
Q

What are examples of mood disorders with psychosis and what overlaping symptoms do they have with schizophrenia?

A

Bipolar disorder with psychosis -

symptoms that overlap: grandiosity (delusions?), flight of ideas (disorganized speech)

Major depression with psychosis-

symptoms that overlap with neg. sx- anhedonia, avolution (lack of energy), affective flattening (disturbned mood?)

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15
Q

What are examples of psychosis due to a substance (4):

A

Intoxication with alcohol

Any illicit drug

Withdrawal - alcohol, sedatives, hypnotics, anxiolytics

Medications- anesthetics, anti-convulsants, anti-histamines, anti-hypertensives, cardiovascular meds, anti-microbial meds, anti-parkinsonian meds, chemotherapeutic agents, STERIODS, GI meds, muscle relaxants, NSAIDS, OTC, anti-depressants, disulfiram

  • *Typically resolves quickly*
  • *Half of the schizo pt have or have had an illict drug disorder which makes it more difficult*
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16
Q

What are examples of general medical condtions that could have overlaping symptoms with schizophrenia?

A

Neurological- neoplasms, dementia, CVAs, epilepsy, CNS infection, Huntington’s disease

Endocrine - hyper/hypo-thyroid, hypoparathyroid, hypoglycemia

Metabolic- delirum due to hypoxia, hypercarbia, hepatic diseases, renal diseases, fluid or electrolyte imbalances

17
Q

What are developmental disorders that could have overlaping symptoms with schizophrenia?

A

Autism, Rhett’s, Aspergers,

Overlaping symptoms: poor communication skills (disorganized thinking/speech), por reciprocal social skills (flat affect, anhedonia?)

Developmental disorders are usually dx in younger age, whereas schizophrenia is more rarely diagnozed young

18
Q

What are 3 major personality disorders and their sx that could be confused with schizophrenia?

A

Paranoid - pattern of distrust, suspiciousness of others (delusions?)

Schizoid - social detachment, restricted affect (neg sx?)

Schizotypal - odd beliefs/unusual perceptual experiences (psychosis?), odd speech (disorg. thinking?), odd/eccentric behavior (disorg. behavior?)

sx are usually milder, have somewhat okay communication skills and personal care; many can still hold jobs; usually not delusional/hallucinations/positive symptoms

19
Q

Schizophrenia Epidemiology:

Incidence in the US:

Lifetime prevalence:

M vs F? Difference in severity?

Peak age onset?

Where do the 2.2 million individuals w/schizophrenia live?

A

Schizophrenia Epidemiology:

Incidence in the US: 0.3 -0.6 per 1000 individuals

Lifetime prevalence: 1%

M vs F? M= F

Typically, severity of illness is worse in males; also the earlier the onset, generally, the more severe.

Peak onset of 1st active phase:

Male - usually earlier; 15/18-25 years; >50% have 1st hospitalization by 25

Females - usually later; 25-35/45; ~33% have 1st hospitalization by age 25

Childhood onset rare, ~1%

Where do the 2.2 million individuals w/schizophrenia live? Majority do not live indenendently (w/family memebrs, in a group/supervised home, in a nursing home,…)

20
Q

What are the 3 phases of schizophrenia?

A

1. Prodromal phase - vague symptoms, social isolation/withdrawal, peculiar behavior, impaired personal hygiene, inappropriate affect, abnormal speech, odd beliefs; often the prodromal phase is not identified until after the first active phase (psychotic break)

2. Active phase (relapse) - patient meets Criteria A for schizophrenia

3. Residual phase (remission) - after active phase(s) have taken place, no longer clearly meets the “A” criteria; much overlap with prodromal phase

21
Q

What cognitive impairment is seen in schizophrenic patients? (5)

When is impairment seen through the course?

What test is frequently used?

What additional impairment does this cause?

A
  • SMART*
  • S: Speed*
  • M: Memory (working, visual, verbal)*
  • A: Attention*
  • R: Reasoning*
  • T: Tact (social congnition)*

Pt are moderately –> severely impaired compared to the general population

Appears early in course, persists and is stable

The Wisconsin Card Sort test is used to analyze these signs

–> Anosognosia = lack of awareness / lack of insigh of illness

some pt have no/partial awareness of their illness; For those that may have awareness, often is still todecline as illness progresses, especially as their illness goes into and out of the active phase

22
Q

What types of substance abuses are seen commonly in schizophrenic patients (3).

What percentage of patients with schizophrenia have or have had, a problem with alcohol or illicit drugs?

A

50% of pt have had/have a problem with Etoh or illict drugs

30-50% alcohol abuse/dependence

10-15% marijuana abuse/dependence

5-10% cocaine abuse/dependence

23
Q

What is the outcome of schizophrenia?

% of favorable course?

% that live independently?

% that don’t work

% that don’t marry

A

What is the outcome of schizophrenia:

% of favorable course? 20%, small # recover completely

GREAT MAJORITY IS UNFAVORABLE:

% that live independently? 33%

% that don’t work: 75%

% that don’t marry: 60-70%

24
Q

Suicide among schizophrenic patients:

Completed suicide?

Attempted?

What are risk factors for suicide amongst schizophrenic pt?

Predictors of worse outcomes (7) vs predictor of better (6):

What is the BEST PROGNOSIS factor?

A

Suicide among schizophrenic patients:

Completed suicide? 6-8% (compare to gen pop 1%)

Attempted? ~20% (50X higher than gen pop)

What are risk factors for suicide amongst schizophrenic pt?

Suicide risk remains present over the entire lifespan for both males and females.

Especially high for YOUNG, MALES with comorbid SUBSTANCE ABUSE

Other risks: depressive sxs, feelings of hopelessness, unemployment

HIGHER RISK: period AFTER psychotic episode / hospital discharge

Predictor of worse outcomes: insidious onset, fam hx, earlier age of onset, male, many negative sxs, minimal to no initial response to meds, substance abuse

Predictor of better outcomes: acute/sudden onset (no premorbid phase), no fam hx, later onset (30’s, 40’s), female, lack of negative sxs, initial response very good to medications (**strongest correlation with outcome**)

25
Q

It is not actually know what causes schizophrenia, what are the top 5 theories to teh etiology of schizophrenia?

A
  1. Neurochemical theory - involving DA (too much?), GABA (too much?), glutamate (too little?)
  2. Infection/Immune theory - virus? increased prevalence in pt born in winter or spring months
  3. Nutritional theory - vit deficiency illnesses (beriberi, pellagra, pernicious anemia), could have psychiatric sx, could schizophrenia do the same? abnl metabolism of lipids/fats, proteins
  4. Endocrine theory - dysfxn of thyroid, adrenal gland, pituitary
  5. Genetics theory - thought > 12 genes invovled

Risk with NO fam hx 1% risk with identical tiwn 50% (not not 100% so not all genetics!), two parents 40%, parent or sibiling 10%

if you find out what casues schizophrenia, you could get “NINE-G

26
Q

What would you use to treat:

MD w/ psychosis?

A

Tx with anti-d’s and anti-psychotic

When pt is no longer psychotic may eventually stop anti-psychotic

continue on anti-D indefinitely

27
Q

What would you use to treat:

Bipolar disorder w/psychosis

A

Tx with mood stabilizers + anti-psychotic (SGA, atypical anti-psychotic can be used as mood stabilizers)

When no longer psychotic discotinue

28
Q

What would you use to treat:

Medical illness with psychosis (delirium)?

A

Tx with anti-psychotic to help psychosis and agitation/prevent unintentional patient injury;

Find and TX underlying medical condition

Discontinue anti-psychotic once delirium resolves

29
Q

What would you use to treat:

Dementia with psychosis

A

TX w/ low dose anti-psychoitc, ideally temp

30
Q

What would you use to treat:

Substance induced psychosis

A

TX acutely w/ anti-psychoitc

psychosis usually resolved in 2-4 days (24-48 hours) once substance is out of the patient’s system

When no longer psychotic - disconntinue meds

31
Q

What would you use to treat:

Schizoaffective disorder?

A

typically treated indefinitely with anti-psychotic meds

32
Q

What would you use to treat:

schizophrenia?

A

typically indefinitely with anti-psychotic meds

33
Q

What are ongoing treatment challenges regarding schizophrenia?

A
  1. treating psychosocial problems - money, food, housing, empolyment, social skills training, medical and dental care
  2. Questions of balancing autonomy with beneficence - does freedom includ the right to be sick wuch that it interferes with or prevents one’s ability to exercise that feedom and make further choices? opposing forced treatment?
  3. Need for assisted treatment? various programs to address challenges of pt not being aware of their illness, are withouth meds, unable to provide for themselves or are a danger to themseves/others; question of advance directives, threat of incareceration, hospitalization/involuntary hospitalization, medication compliance
  4. Victimization: vulnerable to criminals with cognitive and often the victims have difficulty giving a coherent narrative to what happened
  5. Sex, pregnancy and parenthood: although meds affect sexuality and fertility, still about 50% of women with schizophrenia become mothers (almost equal to gen popl). Those with cognitive impairments may have no had the ability to consent to sexual behavior. For pregnant schizophrenics, abitlity for prenatal care may be an issue, and further ability to be a parent is greatly impaired. May opt for adoption. about 33% of mothers with schizophrenia lose custody of their child to a family member, ex-partner, foster care or adoption
  6. Assultive/Violent behavior: magnitude of violence associated with mental illness is comparable to that associated with age, educational attainment, and gender and is limited to only some disorders and symptoms consellations; because serious mental illness is relatively rare and the excess risk modest, the contribution of mental illness to overall levels of violence is miniscule. Risk factors for violence: concurrent alcohol or substance abuse, noncompliance with medication, past hx of assultive behavior.
34
Q

How do patients with schizophrenia present to a physician? (7)

A
  1. “difficult” patients - req more effort to treat with lower likelihood of successful treatment implementation
  2. Poor hisotrians, need for collateral hx
  3. Poor compliance with meds - need help from fam, caseworker
  4. Poor follow through- more effor to get labs, F/U, meds..
  5. Lost to F/U
  6. Poor hygiene
  7. Lack of connection with pt
35
Q

Schizophrenics have higher rates of ….(5), compared to general population:

Comparative treatment?

Life expectancy?

Increased mortality from?

Overall quality of life?

A

Higher rates of obesity, dyslipidemia (5X), HTN, diabetes (2-4X) and cigarette smoking (2-3X)

30% untreated for DM, 62% untreated for HTN, 88% untreated for dyslipidemia

Life expectancy: 48-53y/o

Increased risk from:

Suicide (10% vs 1% gen pop)

CVD (75% vs 50% gen pop)

Overall quality of life: POOR

Many don’t work, don’t marry

quadriplegia, dementia < schizo < blidness, paraplegia