Schizophrenia And Delusional Disorders Flashcards

0
Q

What diagnosis aid may be used when considering schizophrenia in a patient?

A

Refer to Schneiders first rank symptoms- this is a set of features that are indicative of the condition in the absence of organic cerebral pathology.

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1
Q

What is schizophrenia?

A

A debilitating psychiatric disorder characterised by changes in thinking, perception, blunted affect and a reduced level of social functioning

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2
Q

List Schneider’s First Rank Symptoms of schizophrenia

A

Auditory hallucinations- voices repeating thoughts out loud, discussing subject in the first person, running commentary

Thought insertion, withdrawal, broadcasting

Made feelings, impulses, actions

Somatic passivity
Delusional perception

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3
Q

What are the three types of auditory hallucination in schizophrenia?

A

Gedankenlautwerden- voice heard through ears says thoughts out loud as they are being thought; echo de la pensee- voice repeats thoughts just after thinking them; voice says thoughts in anticipation just before they have been thought

Voices discuss the subject in third person

Voices give a running commentary

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4
Q

What are the three types of thought alienation?

A

Thought insertion- do you ever feel as though thoughts being forced into your mind by someone or something else?
Thought withdrawal- have you ever experienced the sensation of having your thoughts taken away from you?
Thought broadcasting- do you ever get the feeling that your thoughts can be read by others, as if they’re being broadcast for all to see?

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5
Q

What does made feelings, impulses and actions mean in Schneiders first-rank?

A

Patient may experience the feeling of free will being removed and that an external agency is controlling his feelings, impulses or actions, may feel under hypnosis

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6
Q

What is somatic passivity?

A

Feeling that one is a passive recipient of bodily sensations by some other external agency.
Do you ever feel as though someone/thing outside yourself is causing you to have odd bodily sensations that you can’t control?

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7
Q

What is a delusional perception?

A

A real perception that is misinterpreted to have special significance or meaning e.g door left open—> I am king of Spain!
Green traffic light—> they’re coming for me!

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8
Q

How many types of schizophrenia are there?

A
9 types
Paranoid (most common)
Hebephrenic
Catatonic (less now)
Undifferentiated 
Residual 
Post schizophrenic depression? 
Simple
Other
Unspecified
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9
Q

Describe other symptoms of schizophrenia not included in first rank?

A

Other persistent delusions- religious or political identity, superhuman powers
Persistent hallucinations- any modality, esp if occur every day, often accompanied by fleeting/ half formed delusions without clear affective content, persistent overvalued ideas

Breaks or interpolations of thought- result in incoherence or irrelevant speech, may cause neologisms

Catatonic behaviour- alternate between stupor (unresponsive, akinetic, mute and fully conscious) and excitement; bizarre posturing; waxy flexibility - limbs can be moulded into position and will stay for long amounts of time; negativism - motiveless resistance to instructions/ attempts to be moved

Negative symptoms- chronic apathy, poverty of speech, lack of drive, slowness and blunting or incongruity of affect—> social withdrawal and decline in social performance

Change in personal behaviour- loss if interest, aimlessness, idleness, self-preoccupied and isolation

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10
Q

What is a neologism?

A

A made up word or existing word used in novel, inappropriate way as a result of thought disorder in schizophrenia

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11
Q

What is an overvalued idea?

A

An unreasonable and sustained intense belief/ preoccupation that is demonstrably false and not normally held by others of the patients subculture. It is maintained with less than delusional intensity but with marked emotional investment.

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12
Q

What other MH issues should be screened for in consideration of negative symptoms in schizophrenia?

A

Depression and antipsychotic medication side effects

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13
Q

What is the clinical picture of paranoid schizophrenia?

A

Delusions of persecution - others are plotting/ out to get them
Delusions of reference- believing that strangers/TV/radio or newspapers are referring to the patient
Delusions of exalted birth- having a special mission, the messiah
Delusions of bodily change
Delusions of jealousy
Hallucinatory voices of a threatening nature or issuing commands
Non- verbal auditory hallucinations e.g whistling, laughing, humming
Hallucinations in other modalities- smell, taste, sexual, visual, other somatic

May not look psychiatrically unwell until paranoid symptoms exposed!

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14
Q

What is the clinical picture of hebephrenic schizophrenia?

A

Irresponsible unpredictable behaviour- exhibiting mannerisms and playing pranks
Rambling and often incoherent speech
Affective changes- incongruous affect, shallow mood, giggling and fatuousness
Poorly organised delusions
Fleeting and fragmentary hallucinations

Onset is normally young 15-25 years And generally has poorer prognosis due to onset of negative symptoms

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15
Q

What is catatonic schizophrenia?

A

Catatonic symptoms of stupor and excitement are present, bizarre posturing, moulding limbs into position, resistance to being moved/ instructed, echolalia, echopraxia

May stop eating and drinking!

Rule out organic conditions eg encephalitis

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16
Q

What is the clinical picture of simple schizophrenia?

A

Not often used, lazy. Meant to have insidious onset of negative symptoms, only made confidently in retrospect.

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17
Q

What is residual or chronic schizophrenia?

A

Acute positive symptoms + chronic negative symptoms - long term diagnosis

18
Q

What is Lyddle’s classification of schizophrenia?

A

He classified the symptoms into 3 syndromes
Psychomotor poverty- poverty of speech, flatness of affect and decreased spontaneous movement
Disorganisation- disorders of thought form and inappropriate affect
Reality distortion- occurrence of delusions and hallucinations
All can coexist in the same person

19
Q

What does PET scan research show about Lyddle’s 3 syndromes?

A

Each is associated with perfusion changes to brain regions
Psychomotor (word generation test) - prefrontal cortex ⬇️
Disorganisation (stroop test) - anterior cingulate cortex ⬆️
Reality distortion (internal monitoring of eye movements) - parahippocampal gyrus/ medial temporal region

20
Q

What other schizophrenia classifications are there?

A

Lyddle’s syndromes
Neurodevelopmental - congenital (poor prognosis ⬆️ negative); adult onset (⬆️positive and mood symptoms, exist on spectrum from bipolar ➡️schizoaffective➡️schizophrenia); late onset (paraphrenia, 60+, good premorbid functioning, associated with auditory and visual deprivations, more common in females, often with organic pathology)

21
Q

What investigations are carried out for a person presenting with schizophrenic symptoms?

A
Further info/ hx
FBC, TFTs, U+Es, LFTs, CRP, fasting g
Consider HIV testing, syphilis serology
Lipids should be checked pre commencing long term antipsychotic meds
MSU
Urine drug screen
CT scan if indicated
EEG (temporal lobe epilepsy esp if visual hallucinations, confusion) 

Symptom rating scales
OT assessment of activities of daily living
Social work assessment of housing, finances, and carers needs
Collateral history

22
Q

What are schizoid/ schizotypal traits when considering premorbid personality?

A

Solitariness, cold affect, suspiciousness and abnormal speech patterns- traits found in 25% of patients
Preclinical manifestation or risk factor?
Studies show schizotypy doubles risk but far from guarantees disease outcome

23
Q

What traits do patients with affective psychosis show when they were younger?

A

None, no difference from peers in national child development survey
Significant difference in schizophrenia patients

24
Q

Describe the schizophrenia prodrome/ At risk mental state

A
Subjective difficulties in attention focusing (irrelevant from pertinent stimuli in somebody's speech etc) 
Clouded thinking
Minor perceptual disturbances 
Anxiety and perplexity 
Reduced sense of control

Typically late teens/ early 20s drops out of college or work, seeming distant and isolate self in room (hard to distinguish between depression, substance misuse, normal teen behaviour!)

Much more common for anxiety, depression and negative symptoms to precede psychosis

25
Q

What is the lifetime risk of schizophrenia?

A

1%

26
Q

What is the age of onset for schizophrenia?

A

Typically between 15-45

Rarely can present in childhood but often associated with developmental delay

27
Q

Male to female ratio of schizophrenia?

A

Equal but males often get it earlier and tend to have it more severely

28
Q

What genetic basis is there for schizophrenia?

A

Lifetime risk increases from 1 to 10% for first degree relatives, nearly 50% if both parents have it/ monozygotic twins, but in 60% no FH known

No single gene, but multiple susceptibility genes interacting together

29
Q

What obstetric complications can predispose to schizophrenia?

A

Prenatal malnutrition, viral infections (rates higher in those born jan-march in northern hemisphere)
Pre-eclampsia, low birth weight, emergency c section➡️ reflect underlying genetic abnormalities or hypoxia brain damage

30
Q

What role does substance misuse play in schizophrenia?

A

Can precipitate the disorder- cannabis, amphetamines, coke and LSD can all produce psychotic symptoms

Cannabis doesn’t cause but increases overall risk, contributing to development in susceptible people, skunk particularly dangerous

Smoking cannabis more than 50 times as a teenager increases risk sixfold, brain vulnerable since still developing

31
Q

What is the physiological link between cannabis and schizophrenia?

A
COMT enzyme breaks down dopamine
Two alleles code for it: Val and Met
Val -Val gas highest risk of precipitating schizophrenia in cannabis users
Heterozygous - intermediate risk 
Met-met- low risk
32
Q

What are the social risk factors for schizophrenia?

A

Disadvantage/ lower SES, related to downward drift due to social withdrawal and unemployment

Urban life and birth ( drift or stress of environment?)

Migration/ ethnicity - first or second generation immigrants have higher rates ( threefold compared to indigenous)
Black carribbean/ African showing highest rates

Family- high expressed emotion e.g criticism or over-involved relatives doubles risk of relapse, but not causative

Schizotypal premorbid personality

Adverse life experience/ abuse

33
Q

What is the histopathological evidence for schizophrenia?

A
  • Neuronal changes in limbic system and temporal lobes
  • Loss of normal cerebral asymmetry
  • Abnormal expression of developmental markers: NCAM and GAP-43
34
Q

What have CT/ MRI studies shown?

A

Enlarged ventricles, overall smaller and lighter brains
No gliosis at post mortem, changes occur before adulthood?

  • Decreased brain volume
  • Smaller limbic system and thalamus
  • Reduced cortical grey matter (esp. prefrontal cortex and superior temporal regions)
  • Increased ventricular volume
  • Widened sulci
  • Present at onset
    Initial brain abnormalities progress as ongoing pruning of synapses and myelination, evolve into overt symptoms
35
Q

What is the dopamine hypothesis?

A

Schizophrenia is a result of dopamine over and underactivity in certain areas of the brain

  • Increased mesolimbic DA activity leads to positive symptoms (hallucinations and delusions)
  • Decreased mesocortical DA activity leads to negative symptoms

Antipsychotics all bind to dopamine receptors and tackle positive symptoms better

  • Amphetamine, cocaine, L-Dopa and bromocriptine (which release dopamine) makes symptoms worse
  • However, antipsychotic biochemical effects only take days, where anti-psychotic effects take weeks- more must be going on!
36
Q

What other neurotransmitter theories exist?

A

5-HT and glutamate

5-HT- antipsychotic clozapine binds to 5-HT receptors and prevents hallucinations
LSD acts at serotonin receptors

Glutamate
Reduced glutamate activity leads to negative symptoms
PCP causes psychosis via NMDA receptors

37
Q

What happens in formal thought disorder?

A

Thoughts become disconnected, loosening of associations, vagueness progresses to very disjointed speech, poverty of thought and thought blocking may occur
Word salad- sentences become nonsensical

38
Q

What is the assessment structure for schizophrenia?

A
Psychiatric history 
Informant history
MSE
Cognitive testing
Physical exam
Hearing and vision - sensory deprivation
39
Q

What is the dDx for schizophrenia?

A

Organic - substance misuse (drug free inpatient admission), dementia/ delirium, epilepsy, medication side effects (steroids, dopamine agonists), other eg brain tumour, stroke, HIV, Wilson’s disease, porphyria, neurosyphilis

Acute transient psychotic episode- resolves within a few months, can be stress related

Mood disorder- depression and mania may produce psychotic symptoms, schizophrenia should not be diagnosed in presence of severe mood problems unless the sch symptoms came first!

Schizoaffective disorder- even balance between schizophrenic and affective symptoms

Persistent delusional disorder- delusions with few if any hallucinations

Schizotypal disorder- state of eccentricity with abnormal thoughts and affect (personality disorder) person is cold, suspicious and aloof with odd ideas

40
Q

What is the biological management of psychosis?

A

Antipsychotics - dopamine antagonists, block post synaptic D2 receptors
Greater affinity- the more effective

Typical- older eg chlorpromazine, haloperidol and depot preparations flupentixol decanoate
Cause distressing EPSEs but still used as effective, cheap and provide depot options (long acting injection)

Atypical antipsychotics- olanzapine, risperidone (available as injection) quetiapine, clozapine, amisulpride, aripiprazole
Indicated in first line treatment in newly diagnosed schizophrenia, unacceptable SEs/ relapse from typical drugs,
Fewer EPSEs, don’t tend to increase prolactin levels as much
Block dopamine and 5ht2 receptors

Avoid using more than one antipsychotic!!!

41
Q

List the side effects of antipsychotics

A

Extrapyramidal - Dystonia, akathisia (restless agitative state), Parkinsonism, tardive dyskinesia

Hyperprolactinaemia-
Galactorrhoea, amenorrhoea, gynaecomastia, hypogonadism
Sexual dysfunction
⬆️osteoporosis risk
Weight gain (esp olanzapine or clozapine)
Sedation
⬆️dm risk
Dislipidaemia - raised triglycerides and chol (fusilli daemon)

Anticholinergic side effects -
Dry mouth, blurred vision, constipation, urinary retention and tachycardia

Arrhythmias
Seizures (clozapine most risk, reduction of seizure threshold)
Neuroleptic malignant syndrome

42
Q

What is neuroleptic malignant syndrome?

A

Rare but life threatening
Triggered by new antipsychotic or dose increase
Idiosyncratic response to dopamine antagonism

Symptoms - muscle stiffness, rigidity, altered consciousness, disturbance of autonomic nervous system - fever, tachycardia and labile BP

Raised creatine kinase and white cell count
Treatment- stop treatment immediately, get urgent medical care, oft intensive

Cause of death numerous, kidney failure secondary to skeletal muscle breakdown (rhabdomyolysis)