Schizophrenia

Question 1

What are the diagnostic criteria for schizophrenia?

Answer 1

DSM-IV: diagnosis if 2 or more symptoms are present for most of the time during a period of 1 month
Dellusions
Hallucinations
Disorganised
Disorganised ot catatonic behaviour
Negative symptoms: affective (emotional) flattening

Question 2

What are delusion symptoms?

Answer 2

Persecution
Religion
Grandiose
Telepathy

Question 3

What are negative symptoms?

Answer 3

Emotional withdrawal/emptiness
Poor rapport
Social withdrawal 
Lack of drive
Poverty of speech

Question 4

What is the pathophysiology of schizophrenia?

Answer 4

Dopamine hypothesis:
Overactivity of dopaminergic system
Amphetamines may induce psychotic symptoms or worsen schizophrenia, mainly as a result of dopamine release
Teenage use of cannabis an issue
Change in receptor population or signal transduction

Question 5

What is the serotonergic system?

Answer 5

5-HT also implicated
Clozapine greater effects on serotonergic system
Beneficial effects of clozapine on negative symptoms

Question 6

What are the goal of treatment?

Answer 6

To manage the initial psychotic symptoms
Improve the quality of life
Reduce the risk of relapse
All with minimum adverse effects (particularly extrapyramidal effects)
Reduce suicide risk

Question 7

What is the pharmacological basis of therapy?

Answer 7

Alongside CBT and social support
Antipsychotics are dopamine D2 receptor antagonists 
Dirty drugs also antagonists at:
A-adrenoceptors
Muscarinic
Histamine receptors (sedation)
5-HT receptors (mainly 5-HT2)

Question 8

What are conventional antipsychotics?

Answer 8

Phenothiazine in 3 groups:

khrutsliruy

Question 9

who do u like more, sham or georgie

Answer 9

Georgie