Schizophrenia

Question 1

Schizophrenia is characterized by disturbances in 
1. 
2.
3.
4.
5.

Answer 1

1. thinking
2. perception
3. Speech
4. emotion
5. behavior

Question 2

Dx of schizophrenia requires ___ or more positive, negative and/or ________ sx present for at least ____month. At least one of those sx must be ______, _______, or _______

Answer 2

Requires 2 or more positive, negative and/or disorganized sx for at least 1 month.

At least one of those sx must be: delusion, hallucination, or disorganized speech

Question 3

Schizophrenia affects ____% of the population
______% of 1st degree relatives
______% of twins

Answer 3

1%
10%
40-60%

Question 4

Onset of schizophrenia usually occurs between ages:

Answer 4

16-30 y/o

Question 5

If a child has abnormal emotional reactions at a young age and then later develops schizophrenia, they will have more (positive or negative) sx and a (better or worse) prognosis.

1/2 of these pts will complain of ______ sx

Answer 5

More negative sx, worse prognosis

Depression sx

Question 6

Potential causes of schizophrenia include (3)

Answer 6

Genes –> strong genetic component
Overactive dopamine system
Viral infections

Question 7

Non medical tx for schizophrenia

Answer 7

Pt education, hospitalization for acute loss of fxn, involve families, self-care training, social skills training, self help groups, prevention (creating a safe environment to decrease relapse)

Question 8

Neuroleptic drug with the most extrapyramidal sx

Answer 8

Haldol

Question 9

Side effects of neuroleptic drugs

Answer 9

EPS, sedation, orthostasis, QT prolongation, decreased sz threshold, increased prolactin, anticholinergic

Question 10

EPS is most likely to occur in what pt population? (think age and gender)

Answer 10

young men and older women

Question 11

Neuroleptics don’t usually cause laryngeal/pharyngeal spasms but if they do, what should you have on hand to treat the respiratory sx?

Answer 11

O2, diphenhydramine and benztropine

Question 12

How do the atypical antipsychotics ADRs differ from the neuroleptics?

Answer 12

Hyperglycemia, increased prolactin is less severe, increase in lipids, less EPS. Otherwise they are the same

Question 13

In what case would Clozaril be beneficial for a pt to take? What must be monitored?

Answer 13

Schizophrenia pts w/ suicidal thoughts. Must monitor WBC for agranulocytosis