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Neuro - Week 7 > Schizophrenia > Flashcards

Schizophrenia Flashcards

1
Q

General term used to describe a distorted perception of reality

A

Psychosis

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2
Q

fixed, false belief that remain despite evidence to the contrary and cannot be accounted for by the cultural background of the individual

A

Delusions

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3
Q

This type of delusion is a false belief that is impossible

A

Bizarre delusion

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4
Q

This type of delusion is a false belief that is plausible but is not true

A

Nonbizarre delusion

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5
Q

This category of delusion is an irrational belief that one is being persecuted

A

Delusions of persecution

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6
Q

This category of delusion is a belief that cues in the external environment are uniquely related to them

A

Ideas of reference

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7
Q

A patient who believed that TV characters are speaking directly to them, is having this category of delusion

A

Ideas of reference

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8
Q

This category of delusion is thought broadcasting and thought insertions

A

Delusions of control

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9
Q

This category of delusion is a belief that one has special powers beyond those of a normal person

A

Delusions of grandeur

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10
Q

This category of delusion is belief that one is infected with a disease

A

Somatic delusions

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11
Q

Heterogeneous syndrome of disorganized and bizarre thoughts, delusions, hallucinations, inappropriate affect, and impaired psychosocial functioning

A

Schizophrenia

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12
Q

When is the typical onset of Schizophrenia?

A

Between 19 and 40 years

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13
Q

Delusions, perceptual disturbances, thought disorder, and disorganized behavior are in this schizophrenia cluster

A

Positive cluster

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14
Q

misinterpretation of an existing sensory stimulus

A

Illusion

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15
Q

sensory perception without actual external stimulus

A

Hallucination

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16
Q

This is the most common type of hallucination

A

Auditory

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17
Q

What is alogia?

A

Reduction in speech
(thought blocking; latency to answer)

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18
Q

This schizophrenia symptom in the negative cluster is decreased interests, social activities, relationships problems

A

Anhedonia

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19
Q

This schizophrenia symptom in the negative cluster is a lack of drive; apathy
Characterized by poor hygiene, decreased motivation (catatonia), decreased goal directed activity

A

Avolition

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20
Q

Impaired executive functioning is in this schizophrenia cluster

A

cognitive cluster

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21
Q

These are the three phases of schizophrenia

A

Prodromal
Psychotic
Residual

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22
Q

This phase of schizophrenia is a decline in function that precedes the first psychotic episode

A

Prodromal

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23
Q

This phase of schizophrenia is a loss of touch with reality, perceptual disturbances, delusions, and disordered thought process

A

Psychotic

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24
Q

This phase of schizophrenia occurs following an episode of active psychosis, marked by mild hallucinations or delusions, social withdrawal, and negative symptoms

A

Residual

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25
Q

Is being male or female a poor prognostic factor for schizophrenia?

A

Male

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26
Q

Is pharmacotherapy an essential element of schizophrenia treatment?

A

YES

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27
Q

What is the MOA of atypical (2nd gen) antipsychotics?

A

Direct blockade of 5-HT2A receptors

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28
Q

Atypical (2nd gen) antipsychotics directly block these receptors

A

5-HT2A receptors

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29
Q

These drugs appear to work by compensatory changes in response to persistent serotonin-2A antagonism and D2 antagonism in limbic (mesolimbic) areas

A

Atypical (2nd gen) antipsychotics

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30
Q

Do Atypical (2nd gen) antipsychotics affect motor systems?

A

Minimal
(contrast to typicals, which cause motor disorders)

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31
Q

Do typical or atypical psychotics cause motor disorders?

A

typicals

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32
Q

Risperidone is this type of drug

A

Atypical (2nd gen) antipsychotic

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33
Q

Quetiapine is this type of drug

A

Atypical (2nd gen) antipsychotic

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34
Q

Aripiprazole is this type of drug

A

Atypical (2nd gen) antipsychotic

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35
Q

Do Typical or Atypical antipsychotics have an adverse effect of increased risk of seizures?

A

Atypical (2nd gen)

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36
Q

Do Typical or Atypical antipsychotics have an adverse effect of hyperlipidemia?

A

Atypical (2nd gen)

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37
Q

Do Typical or Atypical antipsychotics have an adverse effect of hyperglycemia?

A

Atypical (2nd gen)

38
Q

Do Typical or Atypical antipsychotics have an adverse effect of QT prolongation?

A

Atypical (2nd gen)

39
Q

This atypical antipsychotic especially has a risk of QT prolongation

A

Ziprasidone

40
Q

Do Typical or Atypical antipsychotics have an adverse effect of dementia-related psychosis?

A

Atypical (2nd gen)

41
Q

This is the most effective antipsychotic

42
Q

Clozapine blocks these receptors

A

D1, D4, 5-HT2 receptor

43
Q

This antipsychotic has a black box warning of hypotension and hypertension risk

44
Q

This antipsychotic has glucose intolerance and diabetes risk

45
Q

This antipsychotic has a black box warning of agranulocytosis

46
Q

This antipsychotic has a relatively low incidence of extrapyramidal side effects, including tardive dyskinesias but requires frequent monitoring

47
Q

Is Clozapine toxic to the heart?

A

Yes - cardiac toxicity is a black box warning

48
Q

Risperidone blocks these receptors

A

D2 and 5-HT2

49
Q

This antipsychotic has limited effect in nigra-striatal structures at normal (low) therapeutic doses
Higher doses may produce motor dysfunction (extrapyramidal motor signs), hyperprolactinemia, sexual dysfunction

A

Risperidone

50
Q

Side effects of this antipsychotic include orthostatic hypotension and reflex tachycardia

A

Risperidone

51
Q

Is orthostatic hypotension or hypertension a side effect of risperidone?

A

Hypotension

52
Q

Is reflex bradycardia or tachycardia a side effect of risperidone?

A

Tachycardia

53
Q

A long acting injectable is available of this atypical antipsychotic

A

Risperidone

54
Q

Cataracts observed in animals occurs with this atypical antipsychotic

A

Quetiapine

55
Q

This side effect is observed in animals with Quetiapine

56
Q

Eye exams are recommended every 6 months for this atypical antipsychotic, which is an alpha-adrenergic blocker

A

Quetiapine

57
Q

This antipsychotic is a D2 and muscarinic receptor antagonist and 5HT2A receptor inverse agonist

A

Olanzapine

58
Q

Drug reaction with eosinophilia and systemic symptoms (DRESS) can occur with this atypical antipsychotic

A

Olanzapine

59
Q

Ziprasidone is an antagonist of these

A

D2, 5HT2 and alpha-1

60
Q

QT prolongation and risk of sudden death are side effects of this atypical antipsychotic
Requires EKG monitoring

A

Ziprasidone

61
Q

What is the main adverse effect of Ziprasidone?

A

QT prolongation and risk of sudden death

62
Q

Suicidality and dementia-related psychosis (avoid use) are black box warnings of this atypical antipsychotic

A

Aripiprazole

63
Q

This drug is less sedating and less weight gain than other atypical antipsychotics

A

Aripiprazole

64
Q

Does aripiprazole cause more or less sedation and weight gain than other atypicals?

65
Q

What is the MOA of typical antipsychotics?

A

Blockade of D2 receptors in mesolimbic areas

66
Q

Typical antipsychotics block this receptor

67
Q

Is this the MOA of typical or atypical antipsychotics:
Direct blockade of 5-HT2A receptors

68
Q

Is this the MOA of typical or atypical antipsychotics:
Blockade of D2 receptors in mesolimbic areas

69
Q

Are typical or atypical antipsychotics effective but with movement disorders?

70
Q

Haloperidol is this type of drug

A

Typical antipsychotic

71
Q

Thioridazine is this type of drug

A

Typical antipsychotic

72
Q

Thiothixene is this type of drug

A

Typical antipsychotic

73
Q

Phenothiazines is another name for this type of antipsychotic

74
Q

Do Typical or Atypical antipsychotics have an adverse effect of anti-histamine, anti-adrenergic, anti-muscarinic?

75
Q

Do Typical or Atypical antipsychotics have an adverse effect of extrapyramidal symptoms (dopamine blockade)?

76
Q

Do Typical or Atypical antipsychotics have an adverse effect of neuroleptic malignant syndrome?
(Fever, autonomic instability, leukocytosis, tremor, elevated CPK, rigidity, excessive sweating, delirium)

77
Q

This disorder involves Oro-facio-lingual daytime movements possibly associated with larger movements of trunks or extremities
May occur as part of progression of psychosis or as result of therapy with dopamine receptor antagonists (typical antipsychotics)

A

Tardive dyskinesias

78
Q

Do typical or atypical antipsychotics block serotonin receptors?

79
Q

Do typical or atypical antipsychotics block dopamine receptors?

80
Q

Do typical or atypical antipsychotics possibly cause Tardive dyskinesias?

A

Typicals
(due to dopamine antagonism)

81
Q

This is the agent of choice for acute episodes of psychosis

A

Haloperidol
(A Butyrophenone - typical antipsychotic)

82
Q

Haloperidol is the agent of choice for this psychosis

A

Acute episodes

83
Q

Thioxanthenes and Butyrophenones are this type of antipsychotic

A

Typical (first gen)

84
Q

This has the same criteria as schizophrenia, but symptoms have lasted between 1 and 6 months

A

Schizophreniform disorder

85
Q

Schizophreniform disorder has the same criteria as schizophrenia, but symptoms have lasted this amount of time

A

Between 1 and 6 months

86
Q

This has the same criteria as schizophrenia but symptoms last less than 1 month with eventual full return to premorbid functioning

A

Brief psychotic disorder

87
Q

Brief psychotic disorder has the same criteria as schizophrenia but symptoms last this amount of time

A

Less than 1 month

88
Q

In this disorder, patients meet criteria for either depression or mania AND schizophrenia

A

Schizoaffective disorder

89
Q

Patients with Schizoaffective disorder meet criteria for schizophrenia and either of these

A

Depression or mania

90
Q

In Schizoaffective disorder, delusions and hallucinations must be noted for this amount of time in the absence of mood disorder

91
Q

This is a personality disorder of paranoid, odd or magical beliefs, eccentric, lack of friends and social anxiety
Psychosis criteria is not met

A

Schizotypal

92
Q

This is a personality disorder of solitary activities, lack of enjoyment from social interactions, no psychosis

Neuro - Week 7 (5 decks)

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