Schizophrenia Flashcards

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1
Q

Psychosis

A

broad term referring to a
disconnection from reality
- Typically manifests as hallucinations and/or delusions

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2
Q

Schizophrenia

A

a type of psychosis with
disturbed thought, emotion, language, and behaviour

– It is a brain disease (more likely, brain diseases)

– A disconnection between the brain and the external world it perceives and interacts with

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3
Q

Diagnostic Criteria for Schizophrenia

A

Criterion A. (two or more of the following five + at least one of the first three)

(1)Delusions
(2)Hallucinations
(3)Disorganized Speech
(4)Grossly disorganized or abnormal motor
behavior
(5)Negative symptoms: Alogia, Asociality, Apathy, Anhedonia, Affective Flattening

Criterion B. Social or Occupational Dysfunction

  • For a significant proportion of the time since onset,
    one or more major areas of functioning, such as
    work, interpersonal relations, or self-care are
    markedly below the level achieved prior to illness
    onset (or, if onset during childhood/adolescent,
    failure to achieve expected level of functioning)
  • Must be a pervasive pattern
  • Dysfunction usually appears in many domains

Criterion C. Duration

  • Continuous signs of
    disturbance persist for at least
    6 months.
  • At least 1 month of the 6
    month period (or less time if
    successfully treated), must
    include Criterion A symptoms
  • The remaining time may
    include periods of prodromal or residual symptoms, which may include only negative
    symptoms or attenuated
    positive symptoms
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4
Q

Schizoaffective Disorder

A

Co-occurring mood disorder, either bipolar or depressive
type; two week period of just positive symptoms that
precede or follow the mood episode

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5
Q

Schizophreniform Disorder

A

Criteria the same as schizophrenia but lasts 1 to 6
months; no requirement for decline in functioning

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6
Q

Delusional Disorder

A

Delusions for one month; no other psychotic symptoms;
functioning not impaired; behaviour not bizarre or odd

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7
Q

Brief Psychotic Disorder

A

Positive symptoms that last for one day to one month

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8
Q

Substance/medication-
induced Disorder

A

Symptoms temporally related to use or withdrawal from
a substance

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9
Q

Psychotic Disorder due
to another medical
condition

A

Positive symptoms caused by a medical condition, e.g.,
epilepsy

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10
Q

Delusions

A

Erroneous beliefs that usually involve a misinterpretation of perceptions or experiences

  1. Persecutory/Paranoid
  2. Guilt/Sin
  3. Grandiose
  4. Religious
  5. Somatic
  6. Reference
  7. Being Controlled: Feelings, movements, impulses
  8. Mind Reading
  9. Thought Broadcasting: escape and experienced by others
    10.Thought Insertion: thoughts not own and inserted
    11.Thought Withdrawal: thought cessation and withdrawn
    12.Somatic passivity: bodily sensations imposed by external
    agency

I lock my door at night to people are out to get me

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11
Q

3 Mechanisms of Relevance

A

Reward system is hypersensitive
* Paradoxically, this makes behaviour look like it is not goal-directed
* Affects ability to distinguish between the salience of phenomena

Jumping to conclusions
* Making a decision or forming a belief
with very little information
* Contributes to delusion formation
because beliefs are often formed with
very little evidence

Confirmatory biases:
* Preferentially seek evidence to confirm belief system and reject contradictions

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12
Q

AUDITORY HALLUCINATIONS

A

Auditory is most common (>50% of Sz)
* Not simply an illusion or distortion of sounds in
environment
* Voices usually intensify if
* there is less noise in environment
* ambiguous environment
* stress
* The misattribution of one’s own thoughts
* Not a faulty perceptual process
* In other words, it is not the voices I hear, it is the
thought I do not recognize as my own

i hear my name when no one really said it to the voices in my head talk to me

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13
Q

Visual Hallucinations

A

15% of Schizophrenia
Patients
– Tend to be unreal objects or parts rather than whole
* A big octopus like monster
* A tail coming from my backside

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14
Q

Tactile Hallucinations

A

incidence of ~5%
– Tend to produce fear and action

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15
Q

Somatic and gustatory hallucinations

A

rare and often associated
with delusions
– My pancreas has been equipped with a flux capacitor,
which allows me to travel back to my birth

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16
Q

Communication Abnormalities

A

Amount:
A. Poverty of speech (often subsumed under Negative Symptoms – Alogia)
B. Pressured speech

Connectedness:
Disorganized speech, aka, formal/positive thought
disorder; often amalgamated with Positive Symptoms)
* Tangentiality - tendency to speak about topics unrelated to the main topic of discussion
* Derailment - lack of connections in ideas
* Circumstantiality - non-direct thinking

17
Q

Avolition/ Apathy

A

Lack of motivation and interest in daily activites

18
Q

Anhedonia

A

Diminished capacity to anticipate and experience pleasurable emotions

19
Q

Asociality

A

Lack of interest in social interactions

20
Q

Alogia

A

Poverty of speech

21
Q

Affective Flattening

A

Lack of emotional expressivity and diminished facial expression

22
Q

The Course of Illness

A

Premorbid - Prodromal - Active - (Chronic or Residual or Recovery)

23
Q

PREMORBID DEVELOPMENT

A

Concept of Neurodevelopmental Disease
* The primary brain insult(s) and/or pathological processes
occur long before clinical manifestation
* Minor physical anomalies: often the result of 2nd trimester
insults - critical time for neuronal migration
* High palate
* Low-set ears
* Variations in limb length and angle
* Finger-print patterns
* Webbed digits

24
Q

PRODROMAL PHASE

A

A period of escalating problems with adjustment and
emergence of subclinical symptoms
* Schizotypal symptoms, depression,
academic/occupational failure are common
* Acute onset: symptoms emerge over a few weeks
(typically better Prognosis)
* Gradual Onset: Many months or years of behavioural
change

25
Q

Remission

A

*Mild or less on all psychosis items
* Moderate or less on all negative items
* Sustained at least 2 years

Functional Performance:
* Intact social functioning
* Intact everyday living skills

26
Q

Recovery

A
  • Less precisely defined
  • Convergence of remission and improvement of functional performance: functional independence, maintaining satisfying relationships, being productive, having a sense of
    empowerment, overcoming feelings of stigma
27
Q

Etiology of Schizophrenia

A

Diathesis-Stress Model

  • Diathesis: An underlying vulnerability
  • Results in an increased risk
  • Damage to brain might occur prenatally and lie dormant for years
  • Psychosis tends to be expressed in late teens, early 20s
  • Stress: A trigger or triggers that allows the vulnerability to
    emerge as psychosis
  • Possible that events are needed for its manifestation (stress)
  • Environmental/psychosocial
  • Interaction of brain maturation with underlying risk
  • Drug use: evidence for first psychotic episode corresponding with
    cannabis use
  • Concern: not every case of Sz shows onset with a stresso
28
Q

Sz + Genetics

A

Inherit a tendency for psychosis biologically, not a specific form of schizophrenia

monozygotic twins is 48%
drops to 17% for dizygotic

29
Q

Neurobiology and Neurochemistry: The Dopamine Hypothesis

A

Drugs that increase dopamine (agonists), result in psychotic
symptoms
* Drugs that decrease dopamine (antagonists), reduce
schizophrenia-like behaviour
* Examples include neuroleptics and L-Dopa for Parkinson’s disease

30
Q

Treatment for Sz

A

Antipsychotic Medications

Chlorpromazine
* 1st antipsychotic medications
* Mood disorders, mania, agitation
* Motor abnormality side effects e.g., Parkinston’s like symptoms, tardive dyskenesia

Clozapine
* 2nd generation antipsychotic
* Symptom control with fewer side effects
* Control positive symptoms
* Little effect on negative symptoms, no effect on cognitive symptoms

Family Treatment
*Conceptualizes the patient
as a member of a family
system
* Aims for active involvement
of each family member
* Supports deinstitutionalization

CBT
Focusing on four areas
1.Emotional disturbance
2.Psychotic symptoms
3.Social functioning
4.Risk of relapse

Skills Training
* A learning-based intervention
model for the treatment of
functional disabilities associated
with schizophrenia
* Promotes independence
* Reduces stressors

Cognitive Remediation
* Focused on treating
neurocognitive impairments in
domains such:
* Attention
* Memory
* Problem solving