Schizophrenia Flashcards

1
Q

What is psychosis?

A

It is a form of severe mental disturbance where the individual loses touch with reality

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2
Q

What is psychosis characterized by?

A
  1. Delusions
  2. Hallucinations
  3. Disorganised thoughts and behaviour
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3
Q

What are delusions?

A

It is fixated, false & unshakeable personal beliefs

e.g. “I believed that a girl loved me;
She didn’t.”

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4
Q

What is hallucinations?

A

It is the false perceptions in the absence of a real external stimulus.

e.g. 
"I heard "voices".
Nobody was talking to me.
The "voices" were not like thoughts.
Sometimes they sounded like speech
from my relatives.
Sometimes they sounded like speech
from my friends.
Sometimes they sounded like speech
from no one I knew."
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5
Q

What is disorganized thinking?

A

e.g.

- I tried diligently to use good English.
I abandoned sentences half way and
started new ones.
I sounded incoherent.
- “The PAP Government had planted a
microchip in me, they used this to
keep track of me.”
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6
Q

What are the types of psychotic disorders?

A
  • Schizophrenia.
  • Schizoaffective Disorder ( In between schizophrenia and manic-depressive psychosis )
  • Schizophreniform Disorder. ( < 6 months symptoms )
  • Brief Psychotic Disorder.
  • Delusional Disorder.
  • Manic-depressive psychosis ( Bipolar disorders )
  • Paranoid disorder
  • Substance-Induced Psychotic Disorder.
  • Psychotic Disorder Due to a Physical Illness
  • Paraphrenia.
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7
Q

What is Schizophrenia?

A
  • A mind this is torn asunder
  • Intellectual and emotional mental activity are fragmented.
  • Not “spilt personality”
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8
Q

What are the schneider 1st rank symptoms?

A
ABCD 
A : Auditory hallucinations
B : Broadcasting of thoughts
C : Controlled thoughts ( Delusions of control )
D : Delusional Perception
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9
Q

What are the positive symptoms for schizophrenia? ( Additional thing on the person )

A
  • Hallucinations

- Delusions

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10
Q

What are the negative symptoms for schizophrenia? ( Lack of something )

A

5As

  1. Lack of facial expression ( Flatten Affect )
  2. Lack of pleasure ( Anhedonia )
  3. Lack of drive and energy ( Apathy )
  4. Lack of interest ( Avolitional )
  5. Lack of speech ( Alogia )
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11
Q

What are the disorganized symptoms?

A
  • thought disorder

- disorganized behaviour

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12
Q

What are the cognitive symptoms?

A
  • Memory impairment

- Executive function impairment

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13
Q

What is diagnostic criteria?

A
  1. Characteristic symptoms :
    2 ( or more ) of the following, each present for a significant portion of time during a 1 month period ( or less if successfully treated )
  • Delusions
  • Hallucinations
  • Disorganised speech ( e.g. frequent derailmeent or incoherence )
  • grossly disorganized or catatonic behaviour
  • Negative symptoms i.e affective flattening, alogia, or avolition
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14
Q

What is diagnostic criteria ?

A
  • Only one criterion A symptom is required if delusions are bizarre or hallucinations consist of a voice keeping up a running commentary on the person’s behaviour or thoughts, or two or more voices conversing with each other
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15
Q

B. Social / Occupational dysfunction

A
  • For the significant portion of the time since the onset of the disturbance, one or more major areas of functioning such as work, interpersonal relations or self care are markedly below the level achieved prior to the onset ( or when the onset is in childhood or adolescence, failure to achieve expected level of interpersonal, academic or occupational achievement )
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16
Q

What is the C : Duration ?

A

Continuous signs of the disturbance persist for at least 6 months.

The 6 months period must at least 1 month of symptoms ( or less if successfully treated ) that meet Criterion A.

During these prodromal or residual periods, the
signs of the disturbance may be manifested by only negative symptoms or two or more symptoms listed in Criterion A present in an
attenuated form (e.g., odd beliefs, unusual perceptual experiences).

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17
Q

What is D : Schizoaffective and mood disorder exclusion?

A

Schizoaffective
Disorder and Mood Disorder With Psychotic Features have been ruled
out because either
( 1 ) no Major Depressive, Manic, or Mixed Episodes
have occurred concurrently with the active-phase symptoms; or
( 2 ) if
mood episodes have occurred during active-phase symptoms, their
total duration has been brief relative to the duration of the active
and residual periods.

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18
Q

What is E. Substance/general medical conditions exclusion

A

The disturbance is
not due to the direct physiological effects of a substance (e.g., a
drug of abuse, a medication) or a general medical condition.

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19
Q

F. Relationship to a pervasive development?

A

If there is a
history of Autistic Disorder or another Pervasive Developmental
Disorder, the additional diagnosis of Schizophrenia is made only if
prominent delusions or hallucinations are also present for at least a
month (or less if successfully treated).

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20
Q

What are the common subtypes?

A
  1. Schizophreniform disorder
  2. Schizoaffective disorder
  3. Delusional disorder
21
Q

What is Schizophreniform Disorder?

A

It is characterized by the presence of the criterion A.

Symptoms of schizophrenia :

  1. Delusions
  2. Hallucinations
  3. Disorganized speech
  4. DIsorganized or catatonic behaviour and negative symptoms

This disorder lasts longer than 1 month but less than 6 months

22
Q

What is schizoaffective disorder?

A
  • An uninterrupted period of illness occurs during which a major depressive
    episode, a manic episode, or a mixed episode occurs with symptoms that
    meet criterion A for schizophrenia. The major depressive episode must
    include criterion A1 (i.e. depressed mood).
  • During the same period of illness, delusions or hallucinations occur for at
    least 2 weeks, in the absence of prominent mood symptoms.
    -Symptoms that meet the criteria for mood episodes are present for a substantial portion of the total active and residual periods of illness
  • The disturbance is not due to the direct physiologic effects of a substance
    (e.g, illicit drugs, medications) or a general medical condition.
  • The bipolar type is diagnosed if the disturbance includes a manic or a
    mixed episode (or a manic or a mixed episode and major depressive
    episodes).
  • The depressive type is diagnosed if the disturbance includes only major
    depressive episodes.
23
Q

What is subtypes of delusional disorder?

A
  1. Erotomania
  2. Paranoid
  3. Persecutory
  4. Grandiose
  5. Somatic
  6. Morbid jealously
24
Q

What is delusional disorder?

A

Characterized by the presence of non
bizarre delusions in the absence of other
mood or psychotic symptoms.

25
Q

According to DSM V,

A
delusions are false
beliefs based on incorrect inference
about external reality that persist despite
the evidence to the contrary and these
beliefs are not ordinarily accepted by
other members of the person's culture or
subculture.
26
Q

What are the positive symptoms for schizophrenia?

A

Delusions
Hallucinations
Disorganized speech & behaviour
Catatonic behaviour ( movement / responses )

27
Q

What are the negative symptoms for schizophrenia?

A
  • Lack of facial expression (Flatten Affect)
  • Lack of pleasure (Anhedonia)
  • Lack of drive and energy (Apathy)
  • Lack of interest (Avolitional)
  • Lack of speech (Alogia)
28
Q

What are the cognitive symptoms for schizophrenia?

A

Affects memory, learning, and understanding

Subtle ; difficult to notice

29
Q

What is the first diagnosis of schizophrenia?

A

Any of the two :
Delusions, Hallucinations and disorganized speech ( at least one from here )

Disorganized/catatonic behaviour and negative symptoms

30
Q

What is the second diagnosis of schizophrenia?

A

Ongoing for 6 months ( at least 1 month of active phrase )

31
Q

What is the third diagnosis of schizophrenia?

A

Not another condition ( drug abuse )

32
Q

What is Schizophreniform Disorder?

A
  • Schizophreniform disorder is characterized by the presence of criterion.
33
Q

What are the symptoms of the schizophreniform disorder?

A

A symptoms of schizophrenia, including delusions, hallucinations, disorganized speech, disorganized or catatonic behavior, and negative symptoms.

34
Q

How long does schizophreniform disorder last?

A
  • The disorder, including its prodromal, active, and residual phases, lasts longer than 1 month but less than 6 months.
35
Q

What is schizoaffective disorder?

A

mental health disorder that is marked by a combination of schizophrenia symptoms, such as hallucinations or delusions, and mood disorder symptoms, such as depression or mania.

The two types of schizoaffective disorder — both of which include some symptoms of schizophrenia — are:

Bipolar type, which includes episodes of mania and sometimes major depression
Depressive type, which includes only major depressive episodes

36
Q

What is the diagnosis of schizoaffective disorder?

A

An uninterrupted period of illness occurs during which a major depressive
episode, a manic episode, or a mixed episode occurs with symptoms that
meet criterion A for schizophrenia. The major depressive episode must
include criterion A1 (i.e. depressed mood).

  • During the same period of illness, delusions or hallucinations occur for at
    least 2 weeks, in the absence of prominent mood symptoms.
  • Symptoms that meet the criteria for mood episodes are present for a
    substantial portion of the total active and residual periods of illness.
  • The disturbance is not due to the direct physiologic effects of a substance
    (e. g, illicit drugs, medications) or a general medical condition.
- The bipolar type is diagnosed if the disturbance includes a manic or a
mixed episode (or a manic or a mixed episode and major depressive
episodes).
  • The depressive type is diagnosed if the disturbance includes only major
    depressive episodes.
37
Q

What are the causes of Schizophrenia?

A
  • Cause(s) unknown
  • Interaction of genetic and environmental
    factors
38
Q

What are the environmental factors?

A
  • Maternal viral infection / malnutrition
  • Obstetric issues (Using recreational drugs)
  • Substance use especially cannabis
39
Q

What is dopamine hypothesis?

A
- Amphetamine (very high doses) 
paranoia, delusions, auditory hallucination
- Also exacerbates symptoms of
schizophrenia.
- Effects blocked by DA antagonist
chlorpromazine
- Phenothiazines (incl. chlorpromazine) & all
other typical neuroleptics block D2
receptors and alleviate (+) symptoms.
40
Q

What is the first line medical treatment?

A

1st generation anti-psychotics includes Thorazine, Fluanxol,

and Haloperidol.

41
Q

What does the 1st generation anti-psychotics treat?

A

the positive symptoms of schizophrenia.

1st generation antipsychotics effectively control the
hallucinations, delusions, and confusion of schizophrenia;
primarily block dopamine receptors and are effective in
treating the “positive” symptoms of schizophrenia.

42
Q

What is the second line medical treatment?

A

2nd generation anti-psychotics include Risperdal, Clozaril, and
Aripiprazole etc

43
Q

What does the 2nd generation anti-psychotics treat?

A

reducing negative symptoms

44
Q

What are the side effects of anti-psychotic medications?

A

Side effects for antipsychotics may cause a patient to stop taking them. Be sure to weigh the risks against the potential
benefits that antipsychotic drugs can provide.

45
Q

What are some mild effects?

A

dry mouth, blurred vision, constipation,
rigidity, tremors, restlessness, drowsiness and dizziness. These side affects usually disappear a few weeks after the person
starts treatment.

46
Q

What are the 2nd generation medical treatment?

A
  1. Abilify (aripiprazole)
  2. Risperdal (risperidone)
  3. Zyprexa (olanzapine)
  4. Seroquel (quetiapine)
  5. Clozaril (clozapine)
47
Q

What are the 2nd generation medical treatment side effects?

A

weight gain and drowsiness.

48
Q

What is Electroconvulsive Therapy (ECT)?

A

Usually for Treatment resistant
 Effective for acute schizophrenia, mania,
depression
 Safe

 Administered under a light general
anesthesia