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schizo Flashcards

1
Q

What agents have high risk of QT prolongation?

A

chlorpromazine
thioridazine
haloperidone
ziprasidone
iloperidone

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2
Q

What agents have high metabolic risk?

A

olanzapine
clozapine
risperidone
paliperidone
quetiapine

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3
Q

What agents should you use if metabolic risk is a concern?

A

aripiprazole
ziprasidone
lurasidone
asenapine

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4
Q

What agents lower seizure threshold?

A

clozapine
chlorpromazine

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5
Q

What agents may cause insomnia?

A

aripiprazole, brexpiprazole

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6
Q

What agents may cause dizziness?

A

asenapine
iloperidol
brexpiprazole
cariprazole

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7
Q

What agents may cause impulsivity?

A

aripiprazole

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8
Q

What agents are prolactin-elevating?

A

FGAs
risperidone
paliperidone
olanzapine

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9
Q

What agents have anticholinergic effects?

A

chlorpromazine
thioridazine (highest)
clozapine
olanzapine

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10
Q

What agents have highest EPS?

A

haloperidol
fluphenazine

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11
Q

At high doses, which SGAs have EPS?

A

risperidone
paliperidone

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12
Q

Smoking has drug interaction with

A

olanzapine
clozapine
(reduces levels via CYP1A2)

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13
Q

Antacids have drug interaction with

A

(reduce absorption of) chlorpromazine

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14
Q

What has interactions with olanzapine-samidorphan?

A

3A4, 1A2, opioid withdrawal/dependence

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15
Q

What has interactions with lumateperone?

A

3A4

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16
Q

risperidone LAI frequency

A

2 weeks

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17
Q

paliperidone (Invega Sustenna) LAI frequency

A

1 month

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18
Q

paliperidone (Invega Trinza) LAI frequency

A

3 months

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19
Q

paliperidone (Invega Hafyera) LAI frequency

A

6 months

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20
Q

aripiprazole (Abilify Maintena) LAI frequency

A

1-2 months

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21
Q

aripiprazole (Aristada) LAI frequency

A

1-2 months

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22
Q

haloperidol decanoate LAI frequency

23
Q

fluphenazine decanoate LAI frequency

24
Q

olanzapine LAI frequency

25
Q

What agents are available as OROS capsules?

A

paliperidone (once a day)

26
Q

What agents are available as ODT?

A

aripiprazole
olanzapine
risperidone

27
Q

What agents are available as sublingual tablets?

28
Q

What agents are available as transdermal patches?

29
Q

What agents are available as liquids?

A

aripiprazole
haloperidol
fluphenazine
risperidone

30
Q

What agents should be taken with food? Minimum calories?

A

ziprasidone, 500 calories
lurasidone, 350
lumateperone

31
Q

What agents can cause somnolence?

A

asenapine
iloperidone
lurasidone
lumateperone
cariprazine

32
Q

Which agent is contraindicated to acute respiratory s/s, asthma, COPD or other lung disease associated with bronchospasm?

33
Q

Which agent is available as an oral inhalation powder?

34
Q

Which agent may cause blue/gray discoloration of skin?

A

chlorpromazine

35
Q

What can be used to treat acute dystonia?

A

benztropine
diphenhydramine

36
Q

What can be used to treat akithisia?

A

propanolol
clonidinep

37
Q

What can be used to treat pseudoparkinsonism?

A

benztropine
ropinirole

38
Q

What can be used to treat tardive dyskinesia?

A

valbenazine
deutetrabenazine

39
Q

What is the MoA of valbenazine and deutetrabenazine?

A

VMAT2 inhibitor

40
Q

Neuroleptic malignant syndrome is a warning for which EPS medications?

A

deutetrabenazine

41
Q

What should you do for a patient who is experiencing EPS on an antipsychotic agent?

A

Reduce dose OR switch to other agent with lower risk of EPS

42
Q

What may a patient experience during neuroleptic malignant syndrome?

A

Hyperthermia, confusion, stupor, diaphoresis, tachycardia,
increase CPK and muscle rigidity

43
Q

How should you treat a patient experiencing neuroleptic malignant syndrome?

A

D/C antipsychotics
use dantrolene, BZDs, or dopamine agonists

44
Q

Neuroleptic malignant syndrome is more likely to occur when:

A

-a patient is taking typical antipsychotics
-after high dose IM injections
-after recent initiation

45
Q

Difference between FGA and SGA mechanism of action?

A

Both D2 antagonists
Only SGAs are partial serotonin receptor antagonists

46
Q

Which agent may cause excessive drooling?

47
Q

Which agent has a BBW on neutropenia and myocarditis?

48
Q

What is the MoA of samidorphan?

A

mu-opioid receptor antagonist
kappa-/delta-opioid receptor partial agonist

49
Q

What are contraindications to olanzapine-samidorphan?

A

opioid use or acute opioid withdrawal

50
Q

What agent should not be used in end-stage renal disease?

A

olanzapine-samidorpan

51
Q

Which LAI has a BBW for severe sedation/coma?

A

olanzapine (Zyprexa Relprevv)

52
Q

Which agent can cause rare but serious skin reactions? (DRESS)

A

olanzapine-containing agents

54
Q

what agents are prolactin sparing

A

clozapine
quetiapine
ziprasidone
aripiprazole

psych (4 decks)

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