Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

SBL Pharm > SBL Pharm > Flashcards

SBL Pharm Flashcards

1
Q

High expression of p-Glycoprotein means what?

A

Resistance to natural products

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MOA of Alkylating agents?

A

Cross-linking of DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Cisplatin is what kind of drug?

A

Alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Tumor cells can become resistant to alkylating agents how?

A

Increased MGMT, DNA repair enzyme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Carmustine is good at treating what?

A

Brain tumors (lipophilic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cyclophosphamide is what kind of drug?

A

Alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Antimetabolits cause DNA damage during what phase?

A

S phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the MOA of Cytarabine?

A

Converted into ara-CTP and blocks DNA polymerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pemetrexed can cause what side effect?

A

Painful erythema and swelling of the hands and feet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What drug is used to rescue from methotrexate?

A

Leucovorin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the most effective drug for AML?

A

Cytarabine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Vincristine can cause what?

A

Neurotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Topotecan and Irnotecan can cause what?

A

Diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is MOA of anti tumor ABx?

A

Free radicals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the major SE of doxorubicin?

A

Cardiac toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What does doxorubicin inhibit?

A

Topoisomerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What drug causes blue discoloration of fingernails, sclera, and urine?

A

Mitoxantrone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Bleomycin has what SE?

A

Pulmonary toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is a common SE of tyrosine kinase and growth factor receptor inhibitors

A

Acneform skin rash

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Imatinib is an inhibitor of what?

A

Bcr-Abl

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the first line therapy for CML?

A

Imatinib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is the MOA of Ziz-aflibercept

A

An IgG that is attached to VEGFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Cyclophosphamide is used for what?

A

Non-Hodgkin lymphomas and Burkitt Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Aldophasmide is broken down into what two things?

A

Phosphoramide mustard and Acrolein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Acrolein causes what?

A

Hemorrhagic cystitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What is the triple therapy used after surgery for breast cancer?

A

Cyclophosphamide, doxorubicin, and Taxane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What is Mechlorethamine

A

Used for T cell lymphoma topically

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What is the SE of mechlorethamine?

A

Blistering

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What is Melphalan used for?

A

Multiple Myeloma with dexamethasone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Chlorambucil is only used for what?

A

Chronic Lymphoblastic Leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Nitrosourease are effective in what kind of cancer?

A

Brain cancer, lipid soluble

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Carmustine what MOA?

A

Alkylates DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What is the SE of Carmustine?

A

Myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

MGMT having tumors are immune to what?

A

Carmustine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What Carmustine used to treat?

A

Malignant gliomas via wafer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

What is Streptozin used for?

A

Pancreatic islet cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

What is the MOA of Streptozin?

A

Attacks the islets of Langerhans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

MOA of Thiotepa?

A

Causes DNA crosslinks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

What is Thiotepa used for?

A

Used in transplants for hematological malignancies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

What is the MOA of procarbazine?

A

Methylates DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Why can Procarbazine not be used as a single agent?

A

Rapidly occurring resistance due to MGMT being elevated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

What is the SE of Procarbazine?

A

Acute leukemia and can interact poorly with alcohol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

What is Procarbazine used for?

A

Hodgkin and gliomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

Bandamustine MOA?

A

Crosslinks DNA and inhibits mitotic check points

45
Q

What is Bandamustine used for?

A

CLL and NHL

46
Q

What is the MOA of Platinum analogues?

A

Bind DNA through crosslinks

47
Q

Cisplatin must be given with what?

A

Normal saline to protect kidney

48
Q

Cisplatin is inactivated by what?

A

Aluminum

49
Q

What are the SE of cisplatin?

A

N/V, peripheral motor and sensory neuropathy and causes myelosuppression as well

50
Q

Cisplatin is used for what?

A

Testicular cancer

51
Q

How does Carboplatin differ for Cisplatin?

A

Doesn’t need IV hydration, less SE

52
Q

What is Carboplatin used for?

A

Carcinoma of the ovary

53
Q

What is the SE of Oxaliplatin?

A

Neurotoxicity

54
Q

What is Oxaliplatin used for?

A

Colorectal and gastric cancer

55
Q

MOA of methotrexate?

A

Folic acid analog that binds DHFR

56
Q

What drugs decrease the renal clearance of methotrexate?

A

Aspirin, NSAIDS, Penicillin, cephalosporins

57
Q

What resistance to methotrexate can be caused by what?

A

Altered DHFR protein, reduced folate carrier or receptor protein

58
Q

Pemetrexed works on what phase?

A

S phase

59
Q

Pemetrexed is used for what?

A

Mesothelioma, non-small cell lung cancer

60
Q

What is the SE of Pemetrexed?

What is the Tx?

A

Hand and foot syndrome, treated with dexamethasone

61
Q

What is Pralatrexate used for?

A

Refractory T cell lymphoma

62
Q

What is 5-Fu used for?

A

Colorectal cancer

63
Q

People who are deficient in dihydropyrimidine dehydrogenase have what when they take 5-FU?

A

Explosive toxicity

64
Q

Capecitabine is a prodrug for what?

A

5-Fu

65
Q

Capecitabine is with what for metastatic colorectal cancer?

A

Capecitabine and oxaliplatin

66
Q

What two drugs are a part of TAS-102

A

Trifluridine and tipiracil

67
Q

TAS-102 is used to treat what?

A

Mutant RAS colorectal cancer

68
Q

What are the two deoxycytidine analogs?

A

Cytarabine and Gemcitabine

69
Q

What is Cytarabine used for?

A

hematologic malignancies

70
Q

What is Gemcitabine viable against

A

Solid tumors and hematologic cancer

71
Q

6-mercaptopurine is metabolized by what?

A

HGPRT

72
Q

6-mercaptopurine is used for what?

A

childhood acute leukemia

73
Q

What cannot be given with 6-mercaptopurine?

A

Allopurinol

74
Q

6-thioguanine is used with what?

A

Cytarabine

75
Q

Fludarabine is used for what

A

NHL, CLL

76
Q

What is the MOA of Fludarabine?

A

Interferes with DNA polymerase

77
Q

What is the SE of Fludarabine?

A

Potent immunosuppressant, risk of Jiroveci

78
Q

Cladribine has what SE?

A

immunosuppressive

79
Q

Vinca Alkaloids have what MOA?

A

Inhibit tubular polymerization leading to arrest in metaphase

80
Q

Vinblastine has what side effect?

A

Blistering

81
Q

What class are Vinblastine, Vincristine, and Vinorelbine?

A

Vinca alkaloids

82
Q

Vincristine has what SE?

A

Neurotoxicity and SIADH

83
Q

-Taxel means what. MOA?

A

Attack microtubules, similar to Vinca Alkaloids

84
Q

Cabazitexal is good for drug-resistant tumors, why?

A

Poor substrate for P-glycoprotein

85
Q

Which Taxel inhibits microtubules?

A

Ixabepilone

86
Q

Eribulin MOA?

A

Inhibits microtubule function leading to block in G2-M

87
Q

Eribulin is approved for what cancer?

A

Metastatic breast cancer

88
Q

Etoposide MOA?

A

Forms a complex with topoisomerase leading to inhibition of DNA synthesis

89
Q

What major SE can camptothecins cause?

A

Early and late form diarrhea

90
Q

-tecan what MOA?

A

camptothecins, inhibit topoisomerase I

91
Q

Irontecan is a prodrug for what?

A

SN-38, more potent topo inhibitor

92
Q

Anthracyclines consist of what?

A

Doxorubicin, daunorobicin, idarubicin, epirubicin, mitoxantrone,

93
Q

Anthracyclines MOA?

A

Inhibition of Topo and generation of free radicals

94
Q

Idarubicin combined with cytarabine is used for what?

A

AML

95
Q

Mitozantrone MOA?

A

Binds to DNA to produce strand breakage

96
Q

What does mitomycin treat?

A

SCC of the anus with 5-FU

97
Q

Bleomycin has what toxicity?

A

Pulmonary

98
Q

Where are tyrosine kinase inhibitors metabolized at?

A

Liver, by CYP3A4

99
Q

-tinib MOA?

A

Tyrosine kinase inhibitors

100
Q

Imatinib is the first line treatment for what?

A

CML

101
Q

Dasatinib is used for what?

A

CML that is resistant to imatinib

102
Q

Niltinib and Basutinib are used for what?

A

CML that is resistant to imatinib

103
Q

GFR inhibitor MOA?

A

Inhibits EGFR and VEGF

104
Q

Cetuximab MOA?

A

Monoclonal antibody directed against EGFR

105
Q

Erlotinib is metabolized by what?

A

CYP3A4

106
Q

Osimertinib has what SE?

A

QT prolongation and cardiomyopathy

107
Q

Bevacizumab targets what?

A

VEGF-A

108
Q

Zic-afibercept has what SE?

A

HTN/thombo/GI/Proteinurea

109
Q

Sorafenib can cause what?

A

Hand-foot syndrome

SBL Pharm (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions