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Markers > SBL > Flashcards

SBL Flashcards

1
Q

CLL/SLL

flow, stain

A

Flow: Kappa-restricted CD19, CD5 clone

Stain CD20, CD5 (No 19)

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2
Q

Somatic Mutation BCL6

A

DLBL

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3
Q

Hairy Cell Leukemia Markers

A

CD25 and CD11c

Poor Harry went bald at 25

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4
Q

Plasma Cell Marker

A

CD138

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5
Q

Reed Sternberg Cells Markers

A

CD15, CD30, Pax-5 Classic Hodgkin Lymphoma

B cell origin but has no CD20

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6
Q

ALK +VE

A

Anaplastic Large Cell Lymphoma (ALCL)

doughnut/horseshoe cell 
young pple (love doughnuts) - better prognosis 
older - poor prognosis... they get faaaat with doughnuts !
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7
Q

Langerhans Cell Histiocytosis Markers

A

CD1a and S100

EOSINOPHILS love it

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8
Q

JAK2 Kinase

A

driver for Myoproliferative neoplasms

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9
Q

early Lymphoblast marker for immaturity

A

TdT (can be proB or proT )

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10
Q

CD34

A

early myeloid lineages

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11
Q

Leukocyte common antigen

A

CD45

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12
Q

Mature B cell MARKER

A

cd19, cd20, cd10, Pax-5

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13
Q

cd16, cd56

A

NK cells

666 - killer number!!!!!

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14
Q

mature T cell

A

CD1-CD8 (not 6/9)

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15
Q

Burkitt Lymphoma translocation

effects
stain marker

A

t(8;14) -> increased MYC oncogene = proliferation
IgH/Myc

DJ Drop the Heavy Myc at 8:14pm when the Burkley starry sky comes out

Tingible macrophages clearing debris
Ki-67 proliferation marker on stain

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16
Q

t(11;14)

A

cyclinD1/IgH
Mantle cell lymphoma –> in mucosa of stomach- lymphomatoid polyposis

11-14 y.old Mentors cycle!

17
Q

RUNX1-RUNX1T1 fusion

translocation
age grp with good prog

A

t (8;21) AML with neutrophilic maturation

Amil RUNs 821 miles around CBF Block - gets BLASTed and arrested

young pt - good prognosis

18
Q

APL (Acute Promyelocytic Leukemia)

effect and risk

Stain

A

t(15;17) PML-RARA
AML subtype

no RA binding -> no differentiation to PMN -> MORE BLASTS

DIC RISK (blasts upregulate TF -> hypercoagulation, increase annexin II receptors -> plasminogen -plasmin - fibrinolysis -> bleed

Stain: MPO+ve Auer Rods

19
Q

Immatunib

A

TKI - treats Philadelphia Chromosome
(T9:22) CML

BCR-ABL, -> prolif

Philly Cheese Man is ABL to love active TK

increased leukocytosis, big buffy coat, splenomegalu, EM Hematopoiesis

20
Q

Follicular Lymphoma

translocation , genes, effect

A

t(14,18) IgH/BCL-2 apoptosis suppressor

Grade 3 - more centroblasts

21
Q

ALL translocation

A

t(12, 21) - has better prognosis than without this translocation

22
Q

ALL Markers

tx

A

B cell markers: cd19, cd20, cd10, Pax-5
T cell: CD1-CD8 (not 6/9)
Tdt: in promylolympocytes (T and B)

Tx: chemo, intrathecal therapy

23
Q

Ritcher Transformation drivers

A

TP53/MYC

CLL/SLL transform to aggressive tumor

24
Q

Popcorn Cells, CD20 marker

A

Nodular LP Hodgkin Lymphoma (negative for CD15 AND cd30 whereas classic HL has them)

can transform to DLBCL like Follicular Lymphoma

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