Saunders-Endo Flashcards
portion of the diencephalon of the brain, forming the floor and part of the lateral wall of the third ventricle
hypothalamus
activate, controls, and integrates the peripheral autonomic nervous system, endocrine processes, and many somatic functions, such as body temperature, sleep and appetite
hypothalamus
master gland
pituitary gland
located at the base of the brain
pituitary gland
influenced by the hypothalamus; directly affects the function of the other endocrine glands
pituitary gland
promotes growth of body tissue, influences water absorption by the kidney, and controls sexual development and function
pituitary gland
endocrine glands
adrenal
hypothalamus
ovaries
pancreas
parathyroid
pituitary
testes
thyroid
risk factors for endocrine problems
age
poor diet
heredity
congenital factors
trauma
environmental factors
consequence of other health problems or surgery
hypothalamus hormones
corticotropin-releasing hormone
gonadotropin-releasing hormone
growth hormone-inhibiting hormone
growth hormone-releasing hormone
melanocyte-inhibiting hormone
prolactin-inhibiting hormone
thyrotropin-releasing hormone
anterior pituitary gland hormones
adrenocorticotropic hormone
follicle-stimulating hormone
growth hormone
luteinizing hormone
melanocyte-stimulating hormone
prolactin
somatotropic growth-stimulating hormone
thyroid-stimulating hormone
posterior pituitary gland hormones
oxytocin
antidiuretic hormone (vasopressin)
regulates sodium and electrolyte balance; affects carbohydrate, fat, and protein metabolism; influences the development of sexual characteristics; and sustains the fight-or-flight response
adrenal gland
outer shell of the adrenal gland
adrenal cortex
synthesizes glucocorticoids and mineralocorticoids and secretes small amounts of sex hormones
adrenal cortex
inner core of the adrenal gland
adrenal medulla
works as part of the sympathetic nervous system and produces epinephrine and norepinephrine
adrenal medulla
located in the anterior part of the neck
thyroid gland
controls the rate of body metabolism and growth and produces thyroxine (T4), triiodothyronine (T3), and thyrocalcitonin
thyroid gland
responsible for glucose metabolism, protein metabolism, fluid and electrolyte balance, suppression of the inflammatory response to injury, protective immune response to invasion by infectious agents, and resistance to stress
glucocorticoids: cortisol, cortisone, corticosterone
regulation of electrolyte balance by promoting sodium retention and potassium excretion
mineralocorticoids: aldosterone
located on the thyroid gland
parathyroid gland
control calcium and phosphorus metabolism; produce parathyroid hormone
parathyroid glands
located posteriorly to the stomach
pancreas
influences carbohydrate metabolism, indirectly influences fat and protein metabolism, and produces insulin and glucagon
pancreas
located in the pelvic cavity and produce estrogen and progesterone
ovaries and testes
located in the scrotum, control the development of the secondary sex characteristics, and produce testosterone
testes
regulates hormone secretion by the hypothalamus nd pituitary gland
negative-feedback loop
increased amounts of target gland hormones in the bloodstream decrease secretion of the same hormone an other hormones that stimulate its release
negative-feedback loop
in the client with suspected underactivity of an endocrine gland, a stimulus may be provided to determine whether the gland is capable of normal hormone production
stimulation tests
measured amounts of selected hormones or substances are administered to stimulate the target gland to produce its hormone
stimulation tests
hormone levels produced by the target gland are measured
stimulation tests
failure of the hormone level to increase with stimulation indicates hypofunction
stimulation tests
test used when hormone levels are high or in the upper range of normal
suppression tests
why are agents that normally induce a suppressed response administered during suppression tests?
to determine whether normal negative feedback is intact
what does a failure of hormone production to be suppressed during standardized testing indicate?
hyperfunction
it is used to distingush between cushing’s syndrome and cushing’s disease
overnight dexamethasone suppression test
what is the source of excess cortisol in cushing’s disease?
the source of excess cortisol is the pituitary gland rather than the adrenal cortex or exogenous corticosteroid administration
it is a potent long-acting corticosteroid given at bedtime that should suppress the morning cortisol in clients without cushing’s disease by suppressing AcTH production
dexamethasone
this thyroid function test measures the absorption of an iodine isotope to determine how the thyroid gland is functioning
radioactive iodine uptake
a small dose of radioactive iodine is given by mouth or intravenously
radioactive iodine uptake
in radioactive iodine uptake, the amount of radioactivity is measured in how many hours?
2 to 4 hours and again at 24 hours
radioactive iodine uptake:
what are the normal values for the amount of radioactivity at 2 to 4 hours?
3% to 19% at 2 to 4 hours
radioactive iodine uptake:
what are the normal values for the amount of radioactivity in 24 hours?
11% to 30% in 24 hours
what does an elevated value of radioactive iodine indicate?
hyperthyroidism
decreased iodine intake
increased iodine excretion
what does a decreased value of radioactive iodine indicate?
low T4 level
the use of antithyroid medications
thyroiditis
myxedema
hypothyroidism
contraindication of radioactive iodine uptake test
pregnancy
these blood tests are used to diagnose thyroid disorders
T3 and T4 resin uptake test
these hormones regulate thyroid-stimulating hormone
T3 and T4
normal values for Triiodothyronine (T3)
total T3: 110.4 to 337.7 ng/dL (1.7 to 5.2 pmol/L)
normal values for Thyroxine (T4)
total T4: 5 to 12 mcg/dL (64 to 154 nmol/L)
normal values for Thyroxine, free (FT4)
0.8 to 2.8 ng/dL (10 to 36 pmol/L)
is T4 level elevated in hyperthyroidism?
yes
is T4 level decreased in hypothyroidism?
yes
normal value for thyroid-stimulating hormone
0.5 to 5.0 mIU/L
what does an elevated value of thyroid-stimulating hormone indicate?
primary hypothyroidism
what does a decreased value of thyroid-stimulating hormone indicate?
hyperthyroidism or secondary hypothyroidism
it is performed to identify nodules or growths in the thyroid gland
thyroid scan
in thyroid scan, what is administered first before scanning the thyroid gland?
radioisotope of iodine or technetium
is the level of radioactive medication dangerous to the client or not?
reassure the client that the level of radioactive medication is not dangerous to self or others
why do you need to determine whether the client has received radiographic contrast agents within the past 3 months prior to thyroid scan?
these may invalidate the scan
blood glucose bound to hemoglobin
HbA1c (glycosylated hemoglobin A)
a refletion of how well blood glucose levels have been controlled for the past 90 days
HbA1c (glycosylated hemoglobin A)
is fasting required in HbA1c?
not required
normal reference intervals for HbA1c
<6% (adult without diabetes)
diagnostic tests for pheochromocytoma
24-hour urine collection for vanillylmandelic acid (VMA)
normal range of urinary catecholamines (epinephrine)
epinephrine: less than 20 mcg/day (less than 109 nmol/day)
normal range of urinary catecholamines (norepinephrine)
norepinephrine: less than 100 mcg/day (less than 590 nmol/day)
hyposecretion of one or more of the pituitary hormones caused by tumors, trauma, encephalitis, autoimmunity, or stroke
hypopituitarism
what hormones are most often affected in hypopituitarism?
hormones most often affected are growth hormone (GH) and gonadotropic hormones (luteinizing hormone, follicle-stimulating hormone), but thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), or antidiuretic hormone (ADH) may be involved
hypersecretion of growth hormone by the anterior pituitary gland in an adult; caused primarily by pituitary tumors
hyperpituitarism (acromegaly)
assessment of patient with hyperpituitarism (acromegaly)
a. large hands and feet
b. thickening and protrusion of the jaw
c. arthritic changes and joint pain, impingement syndromes
d. visual disturbances
e. diaphoresis
f. oily, rough skin
g. organomegaly
h. hypertension, atherosclerosis, cardiomegaly, heart failure
i. dysphagia
j. deepening of the voice
k. thickening of the tongue, narrowing of the airway, sleep apnea
l. hyperglycemia
m. colon polyps, increased colon cancer risk
nursing intervention for hyperpituitarism
provide pharmacological interventions to suppress GH or to block the action of GH
nursing intervention for hyperpituitarism
prepare the client for radiation of the pituitary gland or for stereotactic radiosurgery if prescribed
nursing intervention for hyperpituitarism
prepare the client for hypophysectomy if planned
nursing intervention for hyperpituitarism
provide pharmacological and nonpharmacological interventions for joint pain
nursing intervention for hyperpituitarism
provide emotional support to the client and family, and encourage the client and family to express feelings related to disturbed body image
removal of a pituitary tumor via craniotomy or a sublabial transsphenoidal (endoscopic transnasal) approach
hypophysectomy (pituitary adenectomy, sublabial transsphenoidal pituitary surgery)
complications for craniotomy
increased ICP
bleeding
meningitis
hypopituitarism
complications for the sublabial transsphenoidal surgery
cerebrospinal fluid leak
infection
diabetes insipidus
hypopituitarism
postoperative interventions after hypophysectomy
monitor vital signs, neurological status, and level of consciousness
postoperative interventions after hypophysectomy
elevate the head of the bed
postoperative interventions after hypophysectomy
monitor for increased ICP
postoperative interventions after hypophysectomy
instruct the client to avoid sneezing, coughing, and blowing the nose
postoperative interventions after hypophysectomy
monitor for bleeding
postoperative interventions after hypophysectomy
monitor for and report signs of temporary diabetes insipidus; monitor intake and output, and report excessive urinary output
postoperative interventions after hypophysectomy
if the entire pituitary is removed, clients will require lifelong replacement of ADH, cortisol, and thyroid hormone
postoperative interventions after hypophysectomy
monitor for and report signs of infection and meningitis
postoperative interventions after hypophysectomy
administer antibiotics, analgesics, and antipyretics as prescribed
postoperative interventions after hypophysectomy
perform oral care, which may include mouth rinses, every 4 hours. clients may be instructed to avoid using a toothbrush or to brush teeth gently with an ultrasoft toothbrush for 10 days to 2 weeks after surgery
postoperative interventions after hypophysectomy
following transsphenoidal hypophysectomy, monitor for and report postnasal drip or clear nasal drainage, which might indicate a cerebrospinal fluid leak. clear drainage should be checked for glucose