SAS/Review Flashcards
Which opioids affect serotonin levels?
Why is this important?
Tramadol, fentanyl
Patients on serotoninergic agents should not take!
Can lead to serotonin syndrome
What kind of defense mechanism:
A perosn is angry at their phsysician for cancelling their appointment. They end up cleaning their entire department to avoid thinking about being angry
Sublimation
Channeling anger, discomfort, unpleasant thoughts at productive activities
Which cognitive domain will be affected first in Dementia with Lewy Bodies?
Attention/executive function, visuospatial reasoning
Will also have Parkinsonism
(Parietal lobe)
Which side effect of first-generation antipsychotics is likely to present after decades of use?
Tardive dyskinesia
Due to long term dopamine blockade
Describe the general timeline of symptoms onset during alcohol withdrawal
- 6-48h: ANS hyperactivity
- 12-48h: Seizures
- 12-24h: Hallucinations
- 3-5+ days: Delirium Tremens
Which cognitive domain will be affected first in Frontotemporal Dementia?
Personality changes, language deficits
(Frontal lobe)
What are the risks associated with MAO inhibitors?
- Serotonin Syndrome
- Hypertensive crisis
- Must avoid tyramine-rich foods
- Severe interaction with meperidine
Which drugs increase serum Lithium levels?
- NSAIDs
-
Diuretics
- Thiazides, spironalactone, triamterene
- ACE inhibitors
- Ca2+ channel blockers
- Metronidazole
- Tetracycline
What factors might precipitate delerium?
I-WATCH-DEATH
The slides specifically highlight factors in bold
- Infection - pneumonia
- Withdrawal
- Acute metabolic
- Trauma
- CNS pathology
- Hypoxia/hypercarbia - hypoxia
- Deficiencies
- Endocrine
- Acute vascular
- Toxins - diphenhydramine
- Heavy metal
What is the difference between schizoaffective disorder and schizophrenia?
-
Schizoaffective disorder:
- Mood symptoms regardless of whether psychotic symptoms are present or absent
-
Schizophrenia:
- Mood symptoms only present when psychotic symptoms are present
(Thank you @Nathan Shlobin!)
Which area/circuit of the brain is impaired in Alzheimer’s Disease?
Limbic Network
Abnormal eye movements (nystagmus) are characteristic of which drug intoxication?
Phencyclidine (PCP)
Which antidepressants are contraindicated in patinets with current or history of anorexia nervosa or bulimia nervosa?
Bupropion
Is this neurotransmitter associated with wakefullness or sleep?
Where is it secreted?
Serotonin
Wakefullness
Raphe nuclei (pons)
Which antipsychotics are most likely to have side effects of involuntary facial movements, restlessness, and dystonia?
High-potency first-generation antipsychotics
- Haloperidol
- Fluphenazine
- Trifluoperazine
Hoover’s sign provides evidence for which disorder?
Functional Neurological Disorder (aka conversion disorder)
Is this neurotransmitter associated with wakefullness or sleep?
Where is it secreted?
Orexin
Wakefulness
Lateral hypothalamus
Is this neurotransmitter associated with wakefullness or sleep?
Where is it secreted?
Histamine
Wakefulness
Tuberomamillary nucleus (hypothalamus)
What differentiates Bipolar I from Bipolar II?
- Bipolar I
- At least 1 manic episode lasting 1+ weeks
- Bioplar II
- Hypomania
- Different from mania b/c does not cause marked impairment in social/occupational functioning, does not require hospitalization
- No manic episodes
- Hypomania
E - All of the above
- Bupropion = atypical antidepressant (NE and DA reuptake inhibitor)
- Clonidine, guanfacine = alpha-2 blockers
- Atomoxetine = selective NE reuptake inhibitor
Rapid withdrawal of what hormone can trigger migraine?
Estrogen
- Rapid withdrawal occurs during the following times:
- Perimenopause
- Post-partum
- Perimenstruation
What is the most consistent but non-specific neuroimaging finding in schizophrenia?
Enlarged ventricles
- Almost always found in patients with schizophrenia
- Not specific for schizophrenia