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PHARMACOLOGY > SAS 9 > Flashcards

SAS 9 Flashcards

1
Q

A person’s mood goes far beyond the normal “ups and downs”

A

Affective Disorder

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2
Q

Severe and long-lasting feelings of sadness beyond the precipitating event

A

Depression

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3
Q

Depression results from a deficiency of what?

A

norepinephrine (NE), dopamine, or serotonin (5HT)

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4
Q

Classification of Antidepressants

A

TCAs, MAOIs, SSRIs, Atypical antidepressants (heterocyclic second generation)

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5
Q

TCAs

A

Tricyclic antidepressants

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6
Q

MAOIs

A

Monoamine Oxidase Inhibitors

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7
Q

SSRIs

A

Selective Serotoninreuptake inhibitors

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8
Q

SSRIs are effective after how many weeks?

A

2-4 weeks

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9
Q

TCAs are effective after how many weeks?

A

2-4 weeks

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10
Q

Half-life of TCAs

A

8 to 68 hrs

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11
Q

TCAs Action

A

Reduce the re-uptake of 5HT and NE into nerves

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12
Q

Used for adult outpatients with reactive depression

A

Tranylcypromine (Parnate)

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13
Q

Used for patients who DO NOT respond to or cannot take newer, safer antidepressants

A

Isocarboxazid (Marplan)

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14
Q

Used fie SOME patients who do not respond to newer, safer antidepressants

A

Phenelzine (Nardil)

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15
Q

TCAs Drug-to-drug interactions

A

MAOIs, cimetidine, fluoxetine (prozac), ranitidine, and oral antidepressants

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16
Q

Treatment of patients with depression who are unresponsive to other antidepression agents

A

MAOIs

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17
Q

Peak of TCAs

A

2-4 hrs

18
Q

Peak of MAOIs

A

2-3 hrs

19
Q

This drug can cause an increase in blood pressure

A

MAOIs

20
Q

Food interactions of MAOIs

A

Tyramine or pressor amines: increase blood pressure

21
Q

The newest group of antidepressants

A

SSRIs

22
Q

Specifically block the re-uptake of 5HT, with little to no known effect on NE

A

SSRIs

23
Q

It is associated with congenital abnormalities

A

SSRIs

24
Q

When combined with TCAs, it increases therapeutic and toxic effects

A

SSRIs

25
Q

Normal VALUE OF LITHIUM

A

0.5-1.5 meg/L

26
Q

Eskalith, Lithane, Lithonate, Lithobid

A

Lithium Trade name

27
Q

alters sodium transport in nerve and muscle cells

A

Lithium

28
Q

Inhibits the release of norepinephrine and dopamine but not serotonin from stimulated serotonin

A

Lithium

29
Q

Jerky movements of muscle

A

Clonic movements

30
Q

It causes cardiac dysrhythmias

A

Lithium

31
Q

S/sx of depression

A

mood changes, insomnia, apathy, lack of interest in activities

32
Q

MILD lithium toxicity (no specific antidote for this)

A

Increase fluid intake

33
Q

Studies have not shown efficacy in using antidepressant drugs to treat depression in children and also indicate that there may be an increase in suicidal ideation and suicidal behavior when antidepressants are used to treat depression in children.

A

Anttidepressants in children

34
Q

These antidepressant agents should be avoided in children if at all possible because of the potential for drug-food interactions and the serious side effects

A

MOIs

35
Q

TCAs drugs; clomipramine, imipramine, nortriptyline, and trimipramine have established pediatric dosages

A

true

36
Q

Fluvoxamine and sertraline have established dosage for the treatment of obsessive-compulsive disorder

A

true

37
Q

It is widely to treat depression in adolescents

A

Fluoxetine

38
Q

Contraindicated to renal or hepatic impairment

A

MAOIs

39
Q

They prevent the breakdown of dopamine, serotonin, and norepinephrine by inhibiting what drug?

A

MAOIs

40
Q

In order to counteract the effect of a hypertensive crisis, the drug that we will give to the patient is

A

Regitine

41
Q

It might be caused by a dysfunction or the neurotransmitters; serotonin, norepinephrine, and dopamine

A

ADHD

42
Q
A

PHARMACOLOGY (1 decks)

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