SAS 9

Question 1

A person’s mood goes far beyond the normal “ups and downs”

Answer 1

Affective Disorder

Question 2

Severe and long-lasting feelings of sadness beyond the precipitating event

Answer 2

Depression

Question 3

Depression results from a deficiency of what?

Answer 3

norepinephrine (NE), dopamine, or serotonin (5HT)

Question 4

Classification of Antidepressants

Answer 4

TCAs, MAOIs, SSRIs, Atypical antidepressants (heterocyclic second generation)

Question 5

TCAs

Answer 5

Tricyclic antidepressants

Question 6

MAOIs

Answer 6

Monoamine Oxidase Inhibitors

Question 7

SSRIs

Answer 7

Selective Serotoninreuptake inhibitors

Question 8

SSRIs are effective after how many weeks?

Answer 8

2-4 weeks

Question 9

TCAs are effective after how many weeks?

Answer 9

2-4 weeks

Question 10

Half-life of TCAs

Answer 10

8 to 68 hrs

Question 11

TCAs Action

Answer 11

Reduce the re-uptake of 5HT and NE into nerves

Question 12

Used for adult outpatients with reactive depression

Answer 12

Tranylcypromine (Parnate)

Question 13

Used for patients who DO NOT respond to or cannot take newer, safer antidepressants

Answer 13

Isocarboxazid (Marplan)

Question 14

Used fie SOME patients who do not respond to newer, safer antidepressants

Answer 14

Phenelzine (Nardil)

Question 15

TCAs Drug-to-drug interactions

Answer 15

MAOIs, cimetidine, fluoxetine (prozac), ranitidine, and oral antidepressants

Question 16

Treatment of patients with depression who are unresponsive to other antidepression agents

Answer 16

MAOIs

Question 17

Peak of TCAs

Answer 17

2-4 hrs

Question 18

Peak of MAOIs

Answer 18

2-3 hrs

Question 19

This drug can cause an increase in blood pressure

Answer 19

MAOIs

Question 20

Food interactions of MAOIs

Answer 20

Tyramine or pressor amines: increase blood pressure

Question 21

The newest group of antidepressants

Answer 21

SSRIs

Question 22

Specifically block the re-uptake of 5HT, with little to no known effect on NE

Answer 22

SSRIs

Question 23

It is associated with congenital abnormalities

Answer 23

SSRIs

Question 24

When combined with TCAs, it increases therapeutic and toxic effects

Answer 24

SSRIs

Question 25

Normal VALUE OF LITHIUM

Answer 25

0.5-1.5 meg/L

Question 26

Eskalith, Lithane, Lithonate, Lithobid

Answer 26

Lithium Trade name

Question 27

alters sodium transport in nerve and muscle cells

Answer 27

Lithium

Question 28

Inhibits the release of norepinephrine and dopamine but not serotonin from stimulated serotonin

Answer 28

Lithium

Question 29

Jerky movements of muscle

Answer 29

Clonic movements

Question 30

It causes cardiac dysrhythmias

Answer 30

Lithium

Question 31

S/sx of depression

Answer 31

mood changes, insomnia, apathy, lack of interest in activities

Question 32

MILD lithium toxicity (no specific antidote for this)

Answer 32

Increase fluid intake

Question 33

Studies have not shown efficacy in using antidepressant drugs to treat depression in children and also indicate that there may be an increase in suicidal ideation and suicidal behavior when antidepressants are used to treat depression in children.

Answer 33

Anttidepressants in children

Question 34

These antidepressant agents should be avoided in children if at all possible because of the potential for drug-food interactions and the serious side effects

Answer 34

MOIs

Question 35

TCAs drugs; clomipramine, imipramine, nortriptyline, and trimipramine have established pediatric dosages

Answer 35

true

Question 36

Fluvoxamine and sertraline have established dosage for the treatment of obsessive-compulsive disorder

Answer 36

true

Question 37

It is widely to treat depression in adolescents

Answer 37

Fluoxetine

Question 38

Contraindicated to renal or hepatic impairment

Answer 38

MAOIs

Question 39

They prevent the breakdown of dopamine, serotonin, and norepinephrine by inhibiting what drug?

Answer 39

MAOIs

Question 40

In order to counteract the effect of a hypertensive crisis, the drug that we will give to the patient is

Answer 40

Regitine

Question 41

It might be caused by a dysfunction or the neurotransmitters; serotonin, norepinephrine, and dopamine

Answer 41

ADHD