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PHA 070_DISPENSING > SAS 6 > Flashcards

SAS 6 Flashcards

1
Q

This type of chemical incompatibility can be minimized by changing the order of mixing or mixing the solutions in dilute forms.

A

Tolerated incompatibility

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2
Q

This type of chemical incompatibility can be prevented by the addition or substitution of one of the reacting ingredients of a prescription with another of equal therapeutic value.

A

Adjusted incompatibility

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3
Q

chemical interaction:
adjusted incompatibility
ex.
caffeine + sodium salicylate

what is the remedy?

A

change caffeine to caffeine citrate

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4
Q

what is this type of chemical incompatibility?

  • Dehydrogenation
  • VILEORA
  • Examples:
    Ascorbic acid (white to yellow)
    Epineprhine (yellow to pink)
A

Oxidation

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5
Q

what is this type of chemical incompatibility?

  • Hydrogenation
  • VDGEROA
A

Reduction

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6
Q

what is this type of chemical incompatibility?

  • Examples precipitation and Evolution of gas
A

Acid-Base reactions

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7
Q

What is this type of chemical incompatibility?

  • most common cause of degradation
  • examples: Ester, Amide, ASA
A

Hydrolysis

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8
Q

What is this type of chemical incompatibility?

  • a.k.a Photooxidation, Photolysis
  • Ex. Nifedipine, Nitropusside, Riboflavin, Doxorubicin
A

Photochemical Degradation

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9
Q

what is this type of chemical incompatibility?

  • conversion of an optically active drug to an optically inactive drug
A

Racemization

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10
Q

what is this type of chemical incompatibility?

  • formation of gels
  • Example: Acacia + Fe salts
A

Gelatinization

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11
Q

Incompatibility can occur in what scenarios?

A

Acronym: PADSMFC

Manufacturing
Administration of drugs
Dispensing
Storage
Packaging
Formulation
Compounding

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12
Q

insolubility is?

A

between solid and liquid

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13
Q

immiscibility is?

A

between liquid to liquid

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14
Q

this results when highly hydrated inorganic ions are deprived of organic ions and molecules of adequate water molecules to remain dissolved.

A

Salting-out

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15
Q

absorbs moisture

A

Deliquescence (under liquefaction)

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16
Q

lowers the MP of two solids combined together at room temperature.

A

Eutexia

17
Q

Examples of Eutexia are?

A

acronym: PAST

Phenol
ASA
Salol
Thymol

18
Q

this type of physical incompatibility

-increases vapor pressure
-liberates atmospheric pressure ionization
- examples:
volatile oils, ketones, esters, NTG, Aldehyde, alcohol

A

Vaporization

PHA 070_DISPENSING (2 decks)

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