SAS 6 Flashcards
What are the most frequent raw materials for semi-solids?
Hydrocarbons, Hydrocarbon waxes, Oleaginous substances, Fatty acids and alcohol, Emulsifiers, Polyols, glycerin, sorbitol, Insoluble compounds
What are the factors influencing absorption through the skin?
Partition coefficient of the drug substance, Moisture and temperature in the environment of the skin, Pathologic injury to the skin, Vehicle used
These are frequently employed to increase the viscosity of mineral oil to prevent separation from an ointment.
Hydrocarbon wax
are used in water-removable creams as an emulsifier to develop a certain consistency in the cream.
Stearic acid
are used in creams as AUXILIARY EMULSIFIERS AND EMOLLIENTS.
Stearyl and cetyl alcohol
is the most commonly used in ointment vehicles.
Petrolatum
are hydrophilic mixtures formed by the addition of substances miscible with hydrocarbons and possessing polar groupings such as SO4, sulfonate, carboxyl hydroxyl, or an ether linage
Absorption base
- An oil-in-water emulsion
- appears like cream
Water removable base
- A water-in-oil
absorption base
- these are prepared from mixtures of high and low molecular weights polyethylene glycols.
- a.k.a greaseless ointment
water washable base
Anhydrous ointment are prepared by?
fusion method
what are the three factors to be controlled during manufacture?
time of mixing, temperature, mechanical works including rate of agitation
what are the steps in the manufacture of emulsified semi-solids?
preparation of oil and aqueous phases, mixing of the phases, cooling the semi-solid emulsion, homogenization, storage of semi-solids, transfer of material for packaging.
what is the weight of adult and pedia rectal suppository?
adult: 2g
pedia: 1g
what is the size of the adult and pedia recal suppository?
adult: 32mm
pedia: 16mm
what is the weight of the vaginal suppository?
5g
what is the weight of male and female urethal suppository?
male: 4g
female: 2g
what is the size of male urethal suppository?
140mm
is a measure of the percentage of fat in the crystalline phase to the total fat across a temperature gradient?
Solid-fat index
is a measure of unesterified positions of glyceride molecules and reflects the monoglyceride and diglyceride content of a fatty base?
Hydroxyl value
this value allows prediction of the time required for solidifying the base when it is chilled in the mold.
Solidification value
this represents the number of mg of potassium hydroxide required to neutralize the free acids and saponify the esters controlled in 1g of fat
Saponification value
this value expresses the number of grams of iodine that reacts with 100g of fat or other unsaturated material
Iodine value
the number of milligrams of potassium hydroxide required to neutralize the free acid in 1g of substance is expressed by this value.
Acid value
