Sari/Free150

Question 1

high estrogen in cirrhosis - mech?

Answer 1

1) decreased catabolism of andrestendione (gets converted to E)
2) E triggers more TBG –> decreased circulating T (shifts balance more)

Question 2

PBC (vs PSC) p/w…

Answer 2

PBC p/w itching FIRST (esp at night)

• then sx of cholestasis (xanthelesma, pale stool)

Question 3

topical vitamin used to tx psoriasis

Answer 3

vitD

• calcipotriene
• calcitirol

(nuclear transcription factor that increased keratinocyte diff?)

Question 4

PTT and thombin time

• heparin
• LMWH (-xambans and idraparinaux)

Answer 4

Heparin

• factor 10a (PTT)
• factor 2a (thrombin time)

LMWH
- ONLY 10a

Question 5

key mech of OCPs

Answer 5

suppression of ovulation (decreased GnRH)

Question 6

unfractionated heparin vs fendoparnaux

Answer 6

unfrac heparin has much higher affinity for Xa

Question 7

MDR1

Answer 7

produces an ATP dep efflux pump in TUMOR cells

Question 8

ototox

Answer 8

aminoglycosides
furosemide
vanc
cisplatin

Question 9

Vd of LMW but hydorphilic

Answer 9

ISF

14L

Question 10

ASA _____ Cox 1/2

Answer 10

actylates

Question 11

caspaicin decreases pain by…

Answer 11

casPaicin cleaves subsance P in cns

Question 12

Vanc flushing vs Niacin flushing

Answer 12

vanc = histamine

niacin = PGs

Question 13

bilateral carpal tunnel in hemodialysis pt

Answer 13

2/2 depo of B2 microglobulin

also in hypothyroidism, DM, RA

Question 14

waxing/waning enlarged LN

Answer 14

follicular lymphoma

Question 15

FGF mt in achondroplasia

Answer 15

activating

(of epiphysial plate –> diproporitonate appendicular to axilar growth)

NB: decreased IGF1= proportionate

Question 16

-nib suffix

Answer 16

kinase inhibitor

Question 17

50 y/o male w/
fever
irritability
ulcerative gingivitis
swollen bums
cervical LAP

Answer 17

herpes

Question 18

21 y/o 
- impaired balance
- dysarthria
(progressing over months)
- increase serum transaminases but everything else neg

Answer 18

wilson’s

• check for K/F rings

Question 19

how long for T-cell reponse to kick in in TB infx

Answer 19

2-4 wks

until then, MTB actively replicating and killing the phagocytosing macrophages

Question 20

albuminuria (frothy urine) great screen for…

Answer 20

MCD

DM nephopathy

Question 21

Why none of the following with Li?
- htiazides
NSAIDS
ACEi

Answer 21

Li tx like Na

(so blocking Na resorbption at the DCT or impairng its clearance will increase it’s reabsorption at the PT and TAL - w/ Li)

loop ok - for some reason it’s better if the componsation to happen at hte DCT

Question 22

Spironolactone on T

Answer 22

blocks Leydig cell synth

blocks androgen hormone rc

Question 23

String sign

Apple core sign

Answer 23

string = chrohns

applecore = colon cancer

Question 24

dephenhydramine

Answer 24

REVERSIBLE 1st gen H blocker

Question 25

protein, carbs, fat - calories/g

Answer 25

protein and carbs = 4

fat = 9