SARCOIDOSIS

Question 1

What are the organs affected by Sarcoidosis

Answer 1

Lungs
Skin
Pituitary gland
Eyes
Heart
Liver
Spleen
Kidneys
Joints
Parotid gland

Question 2

What are the pulmonary findings for Sarcoidosis

Answer 2

Hilar lymphadenopathy
Pulmonary fibrosis
Interstitial lung disease
Dyspnea
Cough
Crackles
Lung infiltrates

Question 3

Neural Findings of Sarcoidosis

Answer 3

Hypopituitarism
Decreased ADH secretion leading to diabetes insipidus
Facial nerve palsy

Question 4

Cardiac findings of Sarcoidosis

Answer 4

Restrictive cardiomyopathy
Arrhythmias
Heart block
Pericarditis
Pericardial effusion

Question 5

Skin findings

Answer 5

Erythema Nodosum
Lupus Pesnio

Question 6

Eye findings

Answer 6

Anterior uveitis
Posterior uveitis
Blurry vision
Dry eye

Question 7

Diagnosis

Answer 7

Chest X-ray
Elevated Blood calcium levels
Elevated Vitamin D levels
Elevated ACE
Pulmonary Function test (FEV/FVC>80%)

Question 8

Treatment

Answer 8

Corticosteroids (Prednisone, prednisolone, methylprednisolone)
DMARDS (methotrexate, azathioprine)
Lung Transplant

Question 9

Causes of Sarcoidosis

Answer 9

1) Genetic
HLA-DRB1 polymorphism
2) Environmental
Mycobacterium tuberculosis
Human herpes virus 8 (HHV8)
Lyme disease bacteria
P. acnes

Question 10

Sarcoidosis is common in

Answer 10

African American
Females
Young 30-40yrs

Question 11

Main pathophysiologic feature

Answer 11

Non CASEATING granulomas deposited on different organs

Question 12

Components of non caseating granulomas

Answer 12

Multinucleated giant cell
Epithelioid cells
Lymphocytes ring
Fabroblasts outher ring

Question 13

Components of Multinucleated giant cell

Answer 13

Many macrophages combined together
Multiple nuclei
Asteroid bodies
Schauman bodies