Sarcoidosis

Question 1

Sarcoidosis is a rare multisystem .. disorder of unknown aetiology.

Answer 1

Sarcoidosis is a rare multisystem granulomatous disorder of unknown aetiology.

Question 2

sarcoidosis most frequently affects the …

Answer 2

sarcoidosis most frequently affects the lungs causing a form of interstitial lung disease.

Question 3

Sarcoidosis affects approximately … people per 100,000 in the UK.

Answer 3

Sarcoidosis affects approximately 10-20 people per 100,000 in the UK.

Question 4

Epidemiology of sarcoidosis - UK + worldwide

Answer 4

Sarcoidosis affects approximately 10-20 people per 100,000 in the UK.

There is a great deal of geographic variation in the prevalence and clinical manifestations of sarcoidosis. In Finland the prevalence is approximately 28.2/100,000 whilst in Japan it is far lower at 3.7/100,000.

In the US Black Americans are far more commonly affected than White Americans though this predisposition isn’t always reflected in other countries. Peak age of onset and clinical manifestations varies from country to country and study to study. In the UK onset tends to be between 20 - 40, though it can occur at any age. The condition is generally more common in women with a 2:1 female-to-male ratio.

Question 5

Pulmonary sarcoidosis

The lungs are affected in …% of patients, though signs and symptoms may be absent or subtle.

Answer 5

The lungs are affected in 90% of patients, though signs and symptoms may be absent or subtle.

Question 6

What is the hallmark finding on chest radiograph in sarcoidosis?

Answer 6

Bilateral hilar lymphadenopathy

Question 7

If fibrosis develops a number of signs may be identified on examination: (3)

Answer 7

Fine inspiratory crackles
Exertional desaturations
Clubbing

Question 8

Additionally pulmonary disease may lead to a number of complications: (2)

Answer 8

Pulmonary artery hypertension

Cor pulmonale

Question 9

Ocular sarcoidosis

Answer 9

The eyes are affected in around 30-60% of cases most commonly in the form of uveitis.

Question 10

What is Uveitis?

Answer 10

Uveitis is inflammation of the uvea, a structure composed of (from anterior to posterior) the iris, ciliary body and choroid.

Question 11

Uveitis is inflammation of the uvea, a structure composed of (from anterior to posterior) the iris, ciliary body and choroid.

Answer 11

Anterior uveitis is the inflammation of the iris (iritis) and may involve part of the ciliary body (cyclitis). Pain, redness and photophobia are typical.
Intermediate uveitis is the inflammation of parts of the ciliary body.
Posterior uveitis is the inflammation of the choroid (choroiditis). It may involve retinal vasculitis. Symptoms include floaters and visual loss.

Question 12

Cutaneous sarcoidosis

Answer 12

Skin manifestations are seen in around 25% of patients with sarcoidosis

Question 13

Skin manifestations are seen in around 25% of patients with sarcoidosis

A number of rashes may be seen:

Answer 13

Papular sarcoidosis: multiple papules develop, generally on the head and neck or areas of trauma.
Erythema nodosum: a panniculitis (a condition with inflammation of subcutaneous adipose tissue) characterised by red, painful nodules.
Lupus pernio: a violaceous, nodular rash distributed over the nose and cheeks. It is pathognomonic but rare.

Question 14

Sarcoidosis may manifest itself in many ways.

List 5 manifestations

Answer 14

Hypercalcaemia is seen in around 15% of cases. This occurs due extra-renal synthesis of calcitriol causing 1-α hydroxylation of 25-hydroxyvitamin D and so increases levels of activated vitamin D. This leads to increased levels of calcium.

Renal disease may occur but is rarely clinically relevant. Significant renal disease sometimes occurs secondary to hypercalcaemia which may cause nephrocalcinosis. Granuloma formation can lead to interstitial nephritis but this is rarely of significance.

CNS disease is rare but may be severe. Arthralgia and bone cysts (particularly in the digits) and hepatosplenomegaly may be seen. Cardiac involvement is rare, it can present with arrhythmias, cardiomyopathy and heart failure.

Heerfordt’s syndrome, also termed uveoparotid fever, is a variant of sarcoidosis characterised by uveitis, parotid swelling, fever and facial nerve palsy.

Löfgren’s syndrome is an acute variant of sarcoidosis characterised by bilateral hilar lymphadenopathy, erythema nodosum, arthralgia and fever.

Question 15

In cases of pulmonary sarcoidosis with pulmonary infiltrates and fibrosis a restrictive lung disease pattern is seen.

Answer 15

FVC: the forced (expiratory) vital capacity is a persons maximal expiration following full inspiration.
FEV1: the forced expiratory volume in one second, i.e the volume of FVC expelled after one second.

Question 16

Restrictive pattern

The following changes are seen in restrictive lung disease such as sarcoidosis:

Answer 16

FVC: reduced
FEV1: reduced
FEV1/FVC: > 80%

Question 17

… … … is a characteristic finding in sarcoidosis.

Answer 17

Bilateral hilar lymphadenopathy is a characteristic finding in sarcoidosis.

Question 18

Bedside tests for sarcoidosis / TB

Answer 18

Observations

Mantoux test: both TB and sarcoidosis cause cavitating lung lesions. May be difficult to distinguish.

Question 19

… test: both TB and sarcoidosis cause cavitating lung lesions. May be difficult to distinguish.

Answer 19

Mantoux test: both TB and sarcoidosis cause cavitating lung lesions. May be difficult to distinguish.

Question 20

Bloods in suspected sarcoidosis

Answer 20

Full blood count
Renal function
Liver function tests: sarcoidosis can cause liver disease
ESR/CRP
Bone profile:
Hypercalcaemia is seen in around 15%.
Serum ACE:
Raised in around 70%, levels show a response to treatment. However, it is not accurate enough to be used diagnostically and has limited prognostic value.

Question 21

CXR in sarcoidosis may reveal… (4)

Answer 21

Bilateral hilar and mediastinal lymphadenopathy
Reticulonodular opacities
Airspace opacities
Pulmonary fibrosis

Question 22

Sarcoidosis

Depending on disease progression high-resolution CT may demonstrate: (4)

Answer 22

Lymphadenopathy
Diffuse nodularity
Ground glass opacification
Fibrosis (upper lobe predominance)

FDG PET may be used in select cases where there is ongoing diagnostic uncertainty, particularly where cardiac sarcoidosis is suspected.

Question 23

Special tests in sarcoidosis… (3)

Answer 23

Spirometry: shows a restrictive defect
Tissue biopsy: need to confirm the diagnosis (see diagnosis section below)
Lumbar puncture: if CNS disease suspected

Question 24

Tissue biopsy is needed to absolutely confirm a diagnosis of sarcoidosis, though it may not always be required.
Tissue biopsy is needed to confirm a diagnosis of sarcoidosis. This is of great importance as other conditions that can mimic radiographical appearances of sarcoidosis include other interstitial lung disease, malignancies and TB.

Clinical diagnosis may be made without the need for biopsy following other relevant investigation and discussion at specialist MDTs. The British Thoracic Society: Sarcoidosis Clinical Statement (2020) describe two scenarios where a clinical diagnosis can be made:

Answer 24

Lofgren’s syndrome: there should be no suspicion of other diagnoses. Patients should follow close monitoring and follow-up.
Long-standing pulmonary disease: with a classical initial presentation, with no suspicion of other diagnoses, and stable, typical, imaging findings following MDT discussion.

Question 25

… syndrome: there should be no suspicion of other diagnoses. Patients should follow close monitoring and follow-up.

Answer 25

Lofgren’s syndrome: there should be no suspicion of other diagnoses. Patients should follow close monitoring and follow-up.

Question 26

Long-standing pulmonary disease - sarcoidosis

Answer 26

Long-standing pulmonary disease: with a classical initial presentation, with no suspicion of other diagnoses, and stable, typical, imaging findings following MDT discussion.

Question 27

In those with suspected pulmonary sarcoidosis bronchoalveolar .. ± transbronchial … may be arranged.

The classic histopathological finding in sarcoidosis is a … granuloma. These are collections of macrophages, epithelioid cells, t-lymphocytes (normally CD4 +ve) and giant cells that are noncaseating (or non-necrotising) - that is the centre has not undergone caseating necrosis. This is then surrounded by both T- and B- lymphocytes, mast cells and fibroblasts.

Answer 27

In those with suspected pulmonary sarcoidosis bronchoalveolar lavage ± transbronchial biopsy may be arranged. The classic histopathological finding in sarcoidosis is a noncaseating granuloma. These are collections of macrophages, epithelioid cells, t-lymphocytes (normally CD4 +ve) and giant cells that are noncaseating (or non-necrotising) - that is the centre has not undergone caseating necrosis. This is then surrounded by both T- and B- lymphocytes, mast cells and fibroblasts.

Question 28

The classic histopathological finding in sarcoidosis is a …

Answer 28

The classic histopathological finding in sarcoidosis is a noncaseating granuloma.

Question 29

The classic histopathological finding in sarcoidosis is a noncaseating granuloma.

Answer 29

These are collections of macrophages, epithelioid cells, t-lymphocytes (normally CD4 +ve) and giant cells that are noncaseating (or non-necrotising) - that is the centre has not undergone caseating necrosis. This is then surrounded by both T- and B- lymphocytes, mast cells and fibroblasts.

Brochoalveolar lavage can show features supportive of sarcoidosis including raised lymphocytes and a CD4/CD8 ratio > 4.

Question 30

Brochoalveolar lavage can show features supportive of sarcoidosis including raised lymphocytes and a CD4/CD8 ratio > …

Answer 30

Brochoalveolar lavage can show features supportive of sarcoidosis including raised lymphocytes and a CD4/CD8 ratio > 4.

Question 31

.. staging may be used to stage pulmonary sarcoidosis based upon chest radiograph findings.

Answer 31

Scadding staging may be used to stage pulmonary sarcoidosis based upon chest radiograph findings.

The Scadding staging system was first published in the early 1960’s. It is based on chest radiograph findings and is used to predict the chance of spontaneous resolution. Though widely used it does have its limitations - it correlates relatively poorly with the severity of patients symptoms and does not predict well those who will need treatment.

Question 32

Managing pulmonary disease

Do patients need active treatment in sarcoidosis?

Answer 32

Many patients will not require active treatment for sarcoidosis.

Patients should be counselled on the condition, its prognosis and both the benefits and risks of treatment. It is known that disease will regress in a significant cohort of patients without treatment. Additionally, the treatments themselves carry their own risks.

As such the British Thoracic Society (BTS) state treatment should only be started if:

Potential danger of a fatal outcome or permanent disability or
Unacceptable loss of quality of life
As with all chronic diseases, patients should be offered support and counselling. The optimisation of lifestyle factors may involve smoking cessation, weight loss and dietary advice.

Question 33

As such the British Thoracic Society (BTS) state treatment should only be started if: (in sarcoidosis pulmonary disease)

Answer 33

Potential danger of a fatal outcome or permanent disability or
Unacceptable loss of quality of life

As with all chronic diseases, patients should be offered support and counselling. The optimisation of lifestyle factors may involve smoking cessation, weight loss and dietary advice.

Question 34

Pharmacological treatment of sarcoidosis overview

Answer 34

The decision to initiate drug therapy is influenced by the factors discussed above (risk of fatal outcome/disability or loss of quality of life) and the feelings of the patient.

When indicated it involves the administration of immunosuppressive medications. BTS divides these into three groups:

Steroids

Classical immunosuppressants

Biologics

Question 35

Steroids in sarcoidosis

Answer 35

Prednisolone has been the mainstay of management for many years. Typically initial treatment consists of:

High-dose induction: typically 20 - 40mg each day for 4 - 6 weeks
Dose tapering: the initial dose is gradually reduced (e.g. 5mg every two weeks)
Maintenance dose: typically 5 - 10mg each day
Patients should be monitored for steroid-related side-effects. Bone protection should be strongly considered in patients on prolonged courses.

Withdrawal of therapy may be trialled after the threat to organ/life has resolved. In those who relapse treatment is re-initiated and further attempts are made at withdrawal at 6-12 month intervals.

Question 36

Classical immunosuppressants in sarcoidosis

Answer 36

These are generally considered to be second-line agents. Options include methotrexate, azathioprine, leflunomide and mycophenolate They may be used in patients:

With significant side-effects from steroids
Co-morbidities putting patients at greater risk of steroid-related side effects
Progressive pulmonary disease / unacceptable ongoing symptoms
Inability to taper steroids to an acceptable maintenance dose
Patient aversion to steroid therapy - may be used as initial therapy
All second-line therapies have significant side effect profiles. Baseline full blood count, renal function, liver function and viral hepatitis screen should be arranged. Contraindications to treatment include an eGFR < 30, ALT greater than two times the upper limit of the normal range (unless cause is sarcoidosis) or chronic hepatitis B/C.

Methotrexate, an antimetabolite, is generally the first choice of the second-line agents. Doses are given weekly alongside folic acid supplementation to reduce the risk of myelosuppression. Side effects include the aforementioned myelosuppression, rashes, alopecia and pneumonitis.

Question 37

…, an antimetabolite, is generally the first choice of the second-line agents (in sarcoidosis)

Answer 37

Methotrexate, an antimetabolite, is generally the first choice of the second-line agents.

Doses are given weekly alongside folic acid supplementation to reduce the risk of myelosuppression. Side effects include the aforementioned myelosuppression, rashes, alopecia and pneumonitis.

Question 38

Second line therapies - immunosuppressants in sarcoidosis

What are some contraindications?

Answer 38

All second-line therapies have significant side effect profiles. Baseline full blood count, renal function, liver function and viral hepatitis screen should be arranged. Contraindications to treatment include an eGFR < 30, ALT greater than two times the upper limit of the normal range (unless cause is sarcoidosis) or chronic hepatitis B/C.

Question 39

What is considered third-line therapy for sarcoidosis (pharmacological management)

Answer 39

Biological - third-line therapy

agents are considered third-line therapy. They are indicated after treatment failure and use is directed by specialist tertiary centres.

Anti-tumour necrosis factor (TNF) agents (e.g. infliximab) reduce inflammation by blocking the inflammatory cytokine TNF. They are known to trigger the reactivation of latent TB and as such patients must be screened and treated for latent TB.

Question 40

Anti-tumour necrosis factor (TNF) agents (e.g. infliximab) reduce inflammation by blocking the inflammatory cytokine TNF. They are known to trigger the reactivation of …

Answer 40

Anti-tumour necrosis factor (TNF) agents (e.g. infliximab) reduce inflammation by blocking the inflammatory cytokine TNF. They are known to trigger the reactivation of latent TB and as such patients must be screened and treated for latent TB.

Question 41

What are known to trigger the reactivation of latent TB?

Answer 41

Anti-tumour necrosis factor (TNF) agents (e.g. infliximab) reduce inflammation by blocking the inflammatory cytokine TNF.

Question 42

Lung transplantation is a significant procedure that may be indicated in those with:

…
…

Answer 42

Advanced pulmonary fibrosis

Pulmonary hypertension

Question 43

Lung transplantation

Unilateral vs bilateral transplant? What has better outcome

Answer 43

Bilateral transplant appears to have better outcomes than unilateral ones. Clinically significant recurrent disease is rare.

Question 44

It is estimated there is a reduction in life expectancy in …% of those with sarcoidosis.

Answer 44

It is estimated there is a reduction in life expectancy in 6-8% of those with sarcoidosis.

Question 45

Prognosis of sarcoidosis

Answer 45

Many patients with sarcoidosis will experience spontaneous regression and resolution of the disease. In those with pulmonary disease the chance of this can be predicted with the scadding staging (see above). The disease is known to be more severe in certain races, in black Americans mortality rates of 10% have been seen.

Pulmonary disease (including pulmonary fibrosis and pulmonary hypertension) is the predominant cause of sarcoidosis related death, implicated in around 70% of cases. Cardiac disease accounts for much of the remaining deaths.