SANS CNS Questions review Flashcards
Branches of the meningohypophyseal trunk
Inferior hypophyseal arteries
Dorsal meningeal artery
Medial tentorial artery of Bernasconi-Cassinari
Loss of heterozygosity 1p/19q is characteristic of
Oligodendroglioma
WHO grade 2
Most commonly seen genetic mutation in gemistocytic and fibrillary astrocytomas an mixed oligoastrocytomas
TP53 mutations
Loss of heterozygosity of 10q is most frequently seen in
Primary and secondary GBM Other frequent genetic abnormalities: -EGFR amplification -p16(INK4a) deletion -PTEN mutations -TP53 mutations (more common with secondary GBM)
Primary treatment for posterior fossa JPA
Gross total resection
Primary treatment for suprasellar JPA
Chemo and/or radiation
(Chemo: carboplatinum and vincristine)
Suprasellar JPAs cannot be excised due to resulting visual, hypothalamic, and endocrine morbidity
Pineal mass
Elevated alpha-fetoproteins
Three most likely dx?
Endodermal sinus tumor
Embryonal carcinoma
Immature teratoma
Pineal mass
Elevated beta-hCG
Two most likely dx?
Choriocarcinoma
Mixed germ cell tumors
Best treatment for germinoma?
Intensity-modulated radiation therapy
- Pure germinomas are commonly highly radiosensitive
- Often treated without surgical rsxn
4wk old presents s/p seizure. CTH demonstrates calcified subependymal nodules and physical exam demonstrated hypopigmented macules. Dx? Next step?
Tuberous sclerosis
-Echocardiography to screen for rhabdomyomas
Epilepsy beginning in infancy as infantile spasms is a common presentation of TS
- Autosomal dominant
- Facial angiofibromata
- Shagreen patches
- Ungual fibromas
- Retinal astrocytomas
- Renal cysts
- Renal angiomyolipomas
- Pulmonary lymphangioleiomyomatosis
- Hamartomatous rectal polyps
Tuberous Sclerosis
-Chromosomes 9 and 16
Dynamic T2-weighted MR imaging is performed to distinguish tumefactive demyelination versus glioma. What radiographic feature is most useful in establishing the likely diagnosis?
Demonstration of veins coursing through the lesion
-No angiogenesis exists in TDL
Manifestations (sodium level) of a classic triphasic response following transsphenoidal resection of a large craniopharyngioma are?
1) Hypernatremia
2) Normo or hyponatremia
3) Hypernatremia
1) Initial symptomatic DI s/p surgery (24hrs)
2) Inappropriate vasopressin secretion (4-5 days)
3) DI (up to 2 wks later)
75yo F with a fourth ventricular mass.
Histopathology shows nests of small blue cells amid a pink fibrillary matrix
Dx? MRI characteristics?
Subependymoma
-Iso/hypo intense on T1 and ABSENT contrast enhancement
A 32 year-old male has intractable seizures localized to the left language-dominant supplementary motor area. What neurological deficits will most likely result following surgical resection?
- Temporary mutism
- Contralateral paresis
- Neglect
Transient - resolve within days - weeks s/p surgery
Anomia and finger agnosis are characteristic of which syndrome?
Location of lesion/damage?
Gerstmann’s syndrome
-Dominant parietal damage
Alexia without agraphia
Most likely location of lesion/damage?
Posterior corpus callosum damage
-Disconnection syndrome
Lesion in CPA
- Hypointense on T1
- iso/hyperintense on T2
- Restricted diffusion on DWI
- minimal/no contrast enhancement
Dermoid cyst
-Epidermoid cyst is similar but usually hyperintense on T1 due to cholesterol components
Mitochondrial disorder that causes slowly progressive ptosis and ophthalmoplegia
Kearns-Sayre syndrome
55yo p/w
- Severe HA
- Acute vision loss
- B/L ptosis
- Complete ophthalmoplegia of both eyes
Most likely dx?
Pituitary apoplexy
-Involvement of optic apparatus, possible cavernous sinus involvement (ophthalmoplegia and ptosis)
ETV is performed through which structure?
Tuber cinereum
What do the three standard peaks in a typical MRI spect measure?
- NAA
- Creatine
- Choline
- NAA: Neuronal viability
- Creratine: Internal marker or reference
- Choline: marker of cellular turnover (involved in synthesis of phospholipids)
Other markers:
- Glutamine/glutamate: Astrocyte markers (may be altered in setting of neuronal damage)
- Myoinositol: Astrocyte marker elevated in Alzheimer disease
- Lipids and lactate: elevated in inflammatory processes and necrotic tissue
75yo M is dx with GBM.
-Which genetic abnormality would MOST likely be found in this tumor?
EGFR
Primary GBM account for vast majority of cases in the elderly
-Amplification and overexpression of EGFR gene has been reported in majority of primary GBM
vs. TP53 mutation in secondary GBM
Parkinson’s triangle boundaries in the cavernous sinus (infratrochlear triangle)
- Trochlear nerve
- Ophthalmic division V1 of the trigeminal nerve
The oculomotor nerve is located above
Maxillary division V3 is located below