Sangre Flashcards
Que factor es estimulada su liberación en células endoteliales como tratamiento para sangrado?
Von Willebrand
La circulación hiperfinámica (sonidos altos S1 y S2 y murmuro sistólico) ocurren por anemia severa. En estos pacientes la SaO2 es normal pero la ___ es disminuida
SvO2 - la saturación de oxígeno en la arteria pulmonar por menos concentración de hemoglobina
Patient presents with splenomegaly, anemia, reticulocytosis, ↑ LDH, ↑ unconjugated bilirubin, and ↓ haptoglobin; these findings suggest a diagnosis of hemolytic anemia. He was previously treated with nitrofurantoin. What is his diagnosis?
Glucose-6-phosphate dehydrogenase deficiency (G6PD) results in impaired production of NADPH.
Patients typically develop acute hemolysis 2–3 days after starting medications like anti-malaria drigs or sulfa drugs
This patient’s urinalysis (significant proteinuria, glycosuria, fatty casts) in the setting of lower extremity swelling and weight gain are highly suggestive of nephrotic syndrome. His flank pain and hematuria with an identified filling defect indicate an acute renal vein thrombosis, likely a result of a hypercoagulable state induced by nephrotic syndrome. Which is the cause?
Nephrotic syndrome is characterized by a massive renal loss of protein due to structural damage of the glomerular filtration barrier which leads to the loss of antithrombin III, leading to a hypercoagulable state due to decreased inhibition of Factor IIa and Factor Xa.
A chromosomal t(15;17) translocation is characteristic of acute promyelocytic leukemia (M3), which would explain this patient’s B symptoms (low-grade fever, fatigue) and signs of coagulopathy (easy bruising, fibrinogen).
What treatment do you give her?
Retinoic acid binds its nuclear receptors to stimulate histone acetylation, which promotes gene expression that regulates the maturation and proliferation of granulocytes.
Retinoic acid binds its nuclear receptors to stimulate histone acetylation, which promotes gene expression that regulates the maturation and proliferation of granulocytes. Lab show low leukocyte count. Which of the following actions by the physician is most appropriate?
Discontinue methimazole
This patient recently began taking methimazole, an antithyroid drug, which is associated with a risk of agranulocytosis that usually occurs within the first 3 months of treatment.
